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Rapamycin improves healthspan but not inflammaging in nfκb1-/- mice.
Correia-Melo C, Birch J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk VI, Passos JF. Correia-Melo C, et al. Among authors: passos jf. Aging Cell. 2019 Feb;18(1):e12882. doi: 10.1111/acel.12882. Epub 2018 Nov 23. Aging Cell. 2019. PMID: 30468013 Free PMC article.
We found that, despite showing no beneficial effects in lifespan and inflammaging, rapamycin reduced frailty and improved long-term memory, neuromuscular coordination and tissue architecture. ...
We found that, despite showing no beneficial effects in lifespan and inflammaging, rapamycin reduced frailty and improved long-term m …
Depletion of mitochondria in mammalian cells through enforced mitophagy.
Correia-Melo C, Ichim G, Tait SW, Passos JF. Correia-Melo C, et al. Among authors: passos jf. Nat Protoc. 2017 Jan;12(1):183-194. doi: 10.1038/nprot.2016.159. Epub 2016 Dec 22. Nat Protoc. 2017. PMID: 28005069
Ectopic expression of the ubiquitin E3 ligase Parkin, combined with short-term mitochondrial uncoupler treatment, stimulates widespread mitophagy and effectively eliminates mitochondria. ...
Ectopic expression of the ubiquitin E3 ligase Parkin, combined with short-term mitochondrial uncoupler treatment, stimulates widespre …
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T. Passos JF, et al. Mol Syst Biol. 2010;6:347. doi: 10.1038/msb.2010.5. Epub 2010 Feb 16. Mol Syst Biol. 2010. PMID: 20160708 Free PMC article.
Combining in-silico interactome analysis and functional target gene inhibition, stochastic modelling and live cell microscopy, we show here that there exists a dynamic feedback loop that is triggered by a DNA damage response (DDR) and, which after a delay of several days, locks t …
Combining in-silico interactome analysis and functional target gene inhibition, stochastic modelling and live cell microscopy, we show here …