Search Page
Save citations to file
Email citations
Send citations to clipboard
Add to Collections
Add to My Bibliography
Create a file for external citation management software
Your saved search
Your RSS Feed
Search Results
3 results
Filters applied: . Clear all
Page 1
Rapamycin improves healthspan but not inflammaging in nfκb1-/- mice.
Aging Cell. 2019 Feb;18(1):e12882. doi: 10.1111/acel.12882. Epub 2018 Nov 23.
Aging Cell. 2019.
PMID: 30468013
Free PMC article.
We found that, despite showing no beneficial effects in lifespan and inflammaging, rapamycin reduced frailty and improved long-term memory, neuromuscular coordination and tissue architecture. ...
We found that, despite showing no beneficial effects in lifespan and inflammaging, rapamycin reduced frailty and improved long-term m …
Depletion of mitochondria in mammalian cells through enforced mitophagy.
Correia-Melo C, Ichim G, Tait SW, Passos JF.
Correia-Melo C, et al. Among authors: passos jf.
Nat Protoc. 2017 Jan;12(1):183-194. doi: 10.1038/nprot.2016.159. Epub 2016 Dec 22.
Nat Protoc. 2017.
PMID: 28005069
Ectopic expression of the ubiquitin E3 ligase Parkin, combined with short-term mitochondrial uncoupler treatment, stimulates widespread mitophagy and effectively eliminates mitochondria. ...
Ectopic expression of the ubiquitin E3 ligase Parkin, combined with short-term mitochondrial uncoupler treatment, stimulates widespre …
Item in Clipboard
Feedback between p21 and reactive oxygen production is necessary for cell senescence.
Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T.
Passos JF, et al.
Mol Syst Biol. 2010;6:347. doi: 10.1038/msb.2010.5. Epub 2010 Feb 16.
Mol Syst Biol. 2010.
PMID: 20160708
Free PMC article.
Combining in-silico interactome analysis and functional target gene inhibition, stochastic modelling and live cell microscopy, we show here that there exists a dynamic feedback loop that is triggered by a DNA damage response (DDR) and, which after a delay of several days, locks t …
Combining in-silico interactome analysis and functional target gene inhibition, stochastic modelling and live cell microscopy, we show here …
Item in Clipboard
Cite
Cite