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Sex-specific effects of Cre expression in Syn1Cre mice.
Baghdadi M, Mesaros A, Purrio M, Partridge L. Baghdadi M, et al. Among authors: partridge l. Sci Rep. 2023 Jun 20;13(1):10037. doi: 10.1038/s41598-023-37029-9. Sci Rep. 2023. PMID: 37340054 Free PMC article.
Moreover, we observed a male-specific deficit in learning and long-term memory of Syn1Cre mice that could be a result of decreased visual acuity. ...
Moreover, we observed a male-specific deficit in learning and long-term memory of Syn1Cre mice that could be a result of decreased vi …
Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy.
Juricic P, Lu YX, Leech T, Drews LF, Paulitz J, Lu J, Nespital T, Azami S, Regan JC, Funk E, Fröhlich J, Grönke S, Partridge L. Juricic P, et al. Among authors: partridge l. Nat Aging. 2022 Sep;2(9):824-836. doi: 10.1038/s43587-022-00278-w. Epub 2022 Aug 29. Nat Aging. 2022. PMID: 37118497 Free PMC article.
Brief elevation of autophagy in early adulthood itself induced a long-term increase in autophagy. In mice, a 3-month, early treatment also induced a memory effect, with maintenance similar to chronic treatment, of lysozyme distribution, Man2B1 level in intestinal crypts, P …
Brief elevation of autophagy in early adulthood itself induced a long-term increase in autophagy. In mice, a 3-month, early treatment …
The Role of GCN2 Kinase in Mediating the Effects of Amino Acids on Longevity and Feeding Behaviour in Drosophila.
Srivastava A, Lu J, Gadalla DS, Hendrich O, Grönke S, Partridge L. Srivastava A, et al. Among authors: partridge l. Front Aging. 2022 Jun 21;3:944466. doi: 10.3389/fragi.2022.944466. eCollection 2022. Front Aging. 2022. PMID: 35821827 Free PMC article.
We show that GCN2 function is essential for fly development, longevity and feeding behaviour under long-term, but not short-term, deprivation of all individual essential amino acids (EAAs) except for methionine. ...GCN2 mutants also showed a short-term reject …
We show that GCN2 function is essential for fly development, longevity and feeding behaviour under long-term, but not short-term …
Autophagy in healthy aging and disease.
Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, Palikaras K, Simonsen A, Johansen T, Tavernarakis N, Rubinsztein DC, Partridge L, Kroemer G, Labbadia J, Fang EF. Aman Y, et al. Among authors: partridge l. Nat Aging. 2021 Aug;1(8):634-650. doi: 10.1038/s43587-021-00098-4. Epub 2021 Aug 12. Nat Aging. 2021. PMID: 34901876 Free PMC article. Review.
Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health....
Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate th …
Long-term in vivo imaging of Drosophila larvae.
Kakanj P, Eming SA, Partridge L, Leptin M. Kakanj P, et al. Among authors: partridge l. Nat Protoc. 2020 Mar;15(3):1158-1187. doi: 10.1038/s41596-019-0282-z. Epub 2020 Feb 10. Nat Protoc. 2020. PMID: 32042177
We describe here a simple procedure for anesthetization and uninterrupted long-term in vivo imaging of the epidermis and other larval organs, including gut, imaginal discs, neurons, fat body, tracheae, muscles and hemocytes, for up to 8 h. ...We provide a survey of the eff …
We describe here a simple procedure for anesthetization and uninterrupted long-term in vivo imaging of the epidermis and other larval …
Branched chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control.
Solon-Biet SM, Cogger VC, Pulpitel T, Wahl D, Clark X, Bagley E, Gregoriou GC, Senior AM, Wang QP, Brandon AE, Perks R, O'Sullivan J, Koay YC, Bell-Anderson K, Kebede M, Yau B, Atkinson C, Svineng G, Dodgson T, Wali JA, Piper MDW, Juricic P, Partridge L, Rose AJ, Raubenheimer D, Cooney GJ, Le Couteur DG, Simpson SJ. Solon-Biet SM, et al. Among authors: partridge l. Nat Metab. 2019 May;1(5):532-545. doi: 10.1038/s42255-019-0059-2. Epub 2019 Apr 29. Nat Metab. 2019. PMID: 31656947 Free PMC article.
Elevated branched chain amino acids (BCAAs) are associated with obesity and insulin resistance. How long-term dietary BCAAs impact late-life health and lifespan is unknown. Here, we show that when dietary BCAAs are varied against a fixed, isocaloric macronutrient backgroun …
Elevated branched chain amino acids (BCAAs) are associated with obesity and insulin resistance. How long-term dietary BCAAs impact la …
Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension.
Catterson JH, Khericha M, Dyson MC, Vincent AJ, Callard R, Haveron SM, Rajasingam A, Ahmad M, Partridge L. Catterson JH, et al. Among authors: partridge l. Curr Biol. 2018 Jun 4;28(11):1714-1724.e4. doi: 10.1016/j.cub.2018.04.015. Epub 2018 May 17. Curr Biol. 2018. PMID: 29779873 Free PMC article.
Improved gut health was also associated with reduced relative bacterial abundance. Early IF thus induced profound long-term changes. Pharmacological and genetic epistasis analysis showed that IF acted independently of the TOR pathway because rapamycin and IF acted additive …
Improved gut health was also associated with reduced relative bacterial abundance. Early IF thus induced profound long-term changes. …
The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations.
Rust A, Partridge LJ, Davletov B, Hautbergue GM. Rust A, et al. Among authors: partridge lj. Toxins (Basel). 2017 Oct 27;9(11):344. doi: 10.3390/toxins9110344. Toxins (Basel). 2017. PMID: 29076988 Free PMC article. Review.
They continue to fascinate scientists and the public due to their very high activity and long-term stability which might find useful applications in the therapeutic killing of unwanted cells but can also be used in acts of terror. ...
They continue to fascinate scientists and the public due to their very high activity and long-term stability which might find useful …
Physical and functional outcomes following multidisciplinary residential rehabilitation for prearthritic hip pain among young active UK military personnel.
Coppack RJ, Bilzon JL, Wills AK, McCurdie IM, Partridge LK, Nicol AM, Bennett AN. Coppack RJ, et al. Among authors: partridge lk. BMJ Open Sport Exerc Med. 2016 Apr 1;2(1):e000107. doi: 10.1136/bmjsem-2015-000107. eCollection 2016. BMJ Open Sport Exerc Med. 2016. PMID: 27900174 Free PMC article.
CONCLUSIONS: Among UK military personnel with prearthritic hip pain, MDT residential rehabilitation resulted in improvements in a functional Y-balance test, hip flexion and internal rotation. The study suggests short-term benefits across some outcomes for the current UK mi …
CONCLUSIONS: Among UK military personnel with prearthritic hip pain, MDT residential rehabilitation resulted in improvements in a functional …
Dietary Protein, Metabolism, and Aging.
Soultoukis GA, Partridge L. Soultoukis GA, et al. Among authors: partridge l. Annu Rev Biochem. 2016 Jun 2;85:5-34. doi: 10.1146/annurev-biochem-060815-014422. Epub 2016 Apr 29. Annu Rev Biochem. 2016. PMID: 27145842 Review.
Epidemiological data in humans also link the quality and quantity of dietary proteins to long-term health. Intricate nutrient-sensing pathways fine tune the metabolic responses to dietary AAs in a highly conserved manner. ...
Epidemiological data in humans also link the quality and quantity of dietary proteins to long-term health. Intricate nutrient-sensing …
35 results