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Boosting compromised SARS-CoV-2-specific immunity with mRNA vaccination in liver transplant recipients.
Luxenburger H, Reeg DB, Lang-Meli J, Reinscheid M, Eisner M, Bettinger D, Oberhardt V, Salimi Alizei E, Wild K, Graeser A, Karl V, Sagar, Emmerich F, Klein F, Panning M, Huzly D, Bengsch B, Boettler T, Elling R, Thimme R, Hofmann M, Neumann-Haefelin C. Luxenburger H, et al. Among authors: panning m. J Hepatol. 2023 May;78(5):1017-1027. doi: 10.1016/j.jhep.2023.02.007. Epub 2023 Feb 18. J Hepatol. 2023. PMID: 36804404 Free PMC article.
IMPACT AND IMPLICATIONS: Due to immunosuppressive medication, liver transplant recipients (LTR) display reduced antibody titers upon COVID-19 mRNA vaccination, but the impact on long-term immune memory is not clear. Herein, we demonstrate that after three vaccine doses, th …
IMPACT AND IMPLICATIONS: Due to immunosuppressive medication, liver transplant recipients (LTR) display reduced antibody titers upon COVID-1 …
Case Series: Convalescent Plasma Therapy for Patients with COVID-19 and Primary Antibody Deficiency.
Lang-Meli J, Fuchs J, Mathé P, Ho HE, Kern L, Jaki L, Rusignuolo G, Mertins S, Somogyi V, Neumann-Haefelin C, Trinkmann F, Müller M, Thimme R, Umhau M, Quinti I, Wagner D, Panning M, Cunningham-Rundles C, Laubner K, Warnatz K. Lang-Meli J, et al. Among authors: panning m. J Clin Immunol. 2022 Feb;42(2):253-265. doi: 10.1007/s10875-021-01193-2. Epub 2021 Dec 10. J Clin Immunol. 2022. PMID: 34893946 Free PMC article.
In our cohort, treatment was associated with a reduction in viral load and improvement of clinical symptoms, even when applied over a week after onset of infection. There were no relevant side effects besides a short-term fever reaction in one patient. Longitudinal full-ge …
In our cohort, treatment was associated with a reduction in viral load and improvement of clinical symptoms, even when applied over a week a …
[SARS-CoV-2 infection (COVID-19): what can we expect?].
Kern WV, Biever PM, Rieg S, Panning M. Kern WV, et al. Among authors: panning m. Dtsch Med Wochenschr. 2020 Jun;145(11):740-746. doi: 10.1055/a-1114-3699. Epub 2020 Jun 3. Dtsch Med Wochenschr. 2020. PMID: 32492743 German.
Steroids for anti-inflammatory therapy are not recommended- It is very important to prepare all actors in the health care system for a longer-term burden of inpatients and complications and to create the necessary capacities. ...
Steroids for anti-inflammatory therapy are not recommended- It is very important to prepare all actors in the health care system for a longe …
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants.
Weigang S, Fuchs J, Zimmer G, Schnepf D, Kern L, Beer J, Luxenburger H, Ankerhold J, Falcone V, Kemming J, Hofmann M, Thimme R, Neumann-Haefelin C, Ulferts S, Grosse R, Hornuss D, Tanriver Y, Rieg S, Wagner D, Huzly D, Schwemmle M, Panning M, Kochs G. Weigang S, et al. Among authors: panning m. Nat Commun. 2021 Nov 4;12(1):6405. doi: 10.1038/s41467-021-26602-3. Nat Commun. 2021. PMID: 34737266 Free PMC article.
Here, we test whether intra-host virus evolution during persistent infections could be a contributing factor by characterizing the long-term SARS-CoV-2 infection dynamics in an immunosuppressed kidney transplant recipient. ...
Here, we test whether intra-host virus evolution during persistent infections could be a contributing factor by characterizing the long-t …
Spin state and deep interior structure of Mars from InSight radio tracking.
Le Maistre S, Rivoldini A, Caldiero A, Yseboodt M, Baland RM, Beuthe M, Van Hoolst T, Dehant V, Folkner WM, Buccino D, Kahan D, Marty JC, Antonangeli D, Badro J, Drilleau M, Konopliv A, Péters MJ, Plesa AC, Samuel H, Tosi N, Wieczorek M, Lognonné P, Panning M, Smrekar S, Banerdt WB. Le Maistre S, et al. Among authors: panning m. Nature. 2023 Jul;619(7971):733-737. doi: 10.1038/s41586-023-06150-0. Epub 2023 Jun 14. Nature. 2023. PMID: 37316663
We also find evidence of a slow acceleration in the Martian rotation rate, which could be the result of a long-term trend either in the internal dynamics of Mars or in its atmosphere and ice caps....
We also find evidence of a slow acceleration in the Martian rotation rate, which could be the result of a long-term trend either in t …
The rheology and thermal history of Mars revealed by the orbital evolution of Phobos.
Samuel H, Lognonné P, Panning M, Lainey V. Samuel H, et al. Among authors: panning m. Nature. 2019 May;569(7757):523-527. doi: 10.1038/s41586-019-1202-7. Epub 2019 May 22. Nature. 2019. PMID: 31118524
Here we show that by considering Phobos (the closest satellite of Mars)-the orbital evolution of which is governed by the thermochemical history of Mars, through tidal interactions-we can gain insight into the thermal history and rheology of the planet. We investigated the long- …
Here we show that by considering Phobos (the closest satellite of Mars)-the orbital evolution of which is governed by the thermochemical his …
Comparison of clinical outcomes in hospitalized patients with COVID-19 or non-COVID-19 community-acquired pneumonia in a prospective observational cohort study.
Meyer HJ, Mödl L, Unruh O, Xiang W, Berger S, Müller-Plathe M, Rohde G, Pletz MW, Rupp J, Suttorp N, Witzenrath M, Zoller T, Mittermaier M, Steinbeis F; CAPNETZ study group. Meyer HJ, et al. Infection. 2024 May 18. doi: 10.1007/s15010-024-02292-z. Online ahead of print. Infection. 2024. PMID: 38761325
PURPOSE: Coronavirus disease 2019 (COVID-19) and non-COVID-19 community-acquired pneumonia (NC-CAP) often result in hospitalization with considerable risks of mortality, ICU treatment, and long-term morbidity. A comparative analysis of clinical outcomes in COVID-19 CAP (C- …
PURPOSE: Coronavirus disease 2019 (COVID-19) and non-COVID-19 community-acquired pneumonia (NC-CAP) often result in hospitalization with con …