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Year Number of Results
2009 2
2010 3
2011 4
2012 3
2013 9
2014 9
2015 7
2016 5
2017 5
2018 7
2019 10
2020 12
2021 8
2022 13
2023 9
2024 5

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100 results

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Page 1
Eighteen-year survival after GD2-directed Chimeric Antigen Receptor-Modified Immune Effector Cell Treatment for Neuroblastoma.
Che-Hsing L, Sharma S, Heczey AA, Steffin DHM, Louis CU, Grilley BJ, Thakkar SG, Wu M, Wang T, Rooney CM, Brenner MK, Heslop HE. Che-Hsing L, et al. Res Sq [Preprint]. 2024 Apr 11:rs.3.rs-4232549. doi: 10.21203/rs.3.rs-4232549/v1. Res Sq. 2024. PMID: 38659815 Free PMC article. Preprint.
We report long-term outcomes up to 18 years of a clinical trial treating children with neuroblastoma with EBV-specific T lymphocytes and CD3-activated T cells - each expressing a first-generation chimeric antigen receptor targeting GD2 with barcoded transgenes to allow tra …
We report long-term outcomes up to 18 years of a clinical trial treating children with neuroblastoma with EBV-specific T lymphocytes …
Generation of a humanized mAce2 and a conditional hACE2 mouse models permissive to SARS-COV-2 infection.
Song IW, Washington M, Leynes C, Hsu J, Rayavara K, Bae Y, Haelterman N, Chen Y, Jiang MM, Drelich A, Tat V, Lanza DG, Lorenzo I, Heaney JD, Tseng CK, Lee B, Marom R. Song IW, et al. Mamm Genome. 2024 Mar 15. doi: 10.1007/s00335-024-10033-8. Online ahead of print. Mamm Genome. 2024. PMID: 38488938
Development of pre-clinical animal models is critical to study viral-host interaction, tissue tropism, disease mechanisms, therapeutic approaches, and long-term sequelae of infection. Here, we report two mouse models for studying SARS-CoV-2: A knock-in mAce2(F83Y,H353K) mo …
Development of pre-clinical animal models is critical to study viral-host interaction, tissue tropism, disease mechanisms, therapeutic appro …
Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor-positive Breast Cancer.
Guarducci C, Nardone A, Russo D, Nagy Z, Heraud C, Grinshpun A, Zhang Q, Freelander A, Leventhal MJ, Feit A, Cohen Feit G, Feiglin A, Liu W, Hermida-Prado F, Kesten N, Ma W, De Angelis C, Morlando A, O'Donnell M, Naumenko S, Huang S, Nguyen QD, Huang Y, Malorni L, Bergholz JS, Zhao JJ, Fraenkel E, Lim E, Schiff R, Shapiro GI, Jeselsohn R. Guarducci C, et al. Clin Cancer Res. 2024 May 1;30(9):1889-1905. doi: 10.1158/1078-0432.CCR-23-2975. Clin Cancer Res. 2024. PMID: 38381406 Free PMC article.
CDK7 inhibition resulted in suppression of ER phosphorylation at S118; however, long-term CDK7 inhibition resulted in increased ER signaling, supporting the combination of ET with a CDK7i. ...
CDK7 inhibition resulted in suppression of ER phosphorylation at S118; however, long-term CDK7 inhibition resulted in increased ER si …
Dietary Folate and Cofactors Accelerate Age-dependent p16 Epimutation to Promote Intestinal Tumorigenesis.
Yang L, Peery RC, Farmer LM, Gao X, Zhang Y, Creighton CJ, Zhang L, Shen L. Yang L, et al. Cancer Res Commun. 2024 Jan 19;4(1):164-169. doi: 10.1158/2767-9764.CRC-23-0356. Cancer Res Commun. 2024. PMID: 38259096 Free PMC article.
SIGNIFICANCE: Our study demonstrates that dietary folate and cofactors modulate tumor-suppressor gene methylation to increase intestinal tumorigenesis. Our findings highlight the need for monitoring the long-term safety of folate fortification in high-risk individuals....
SIGNIFICANCE: Our study demonstrates that dietary folate and cofactors modulate tumor-suppressor gene methylation to increase intestinal tum …
Sex differences in paternal arsenic-induced intergenerational metabolic effects are mediated by estrogen.
Xue Y, Gong Y, Li X, Peng F, Ding G, Zhang Z, Shi J, Savul IS, Xu Y, Chen Q, Han L, Mao S, Sun Z. Xue Y, et al. Cell Biosci. 2023 Sep 10;13(1):165. doi: 10.1186/s13578-023-01121-4. Cell Biosci. 2023. PMID: 37691128 Free PMC article.
CONCLUSIONS: These results demonstrate that disrupted reproductive hormone secretion in alliance with hepatic estrogen signaling accounts for the sex-specific intergenerational effects of paternal iAs exposure, which shed light on the sex disparities in long-term gene-envi …
CONCLUSIONS: These results demonstrate that disrupted reproductive hormone secretion in alliance with hepatic estrogen signaling accounts fo …
In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.
De Giorgi M, Park SH, Castoreno A, Cao M, Hurley A, Saxena L, Chuecos MA, Walkey CJ, Doerfler AM, Furgurson MN, Ljungberg MC, Patel KR, Hyde S, Chickering T, Lefebvre S, Wassarman K, Miller P, Qin J, Schlegel MK, Zlatev I, Li RG, Kim J, Martin JF, Bissig KD, Jadhav V, Bao G, Lagor WR. De Giorgi M, et al. bioRxiv [Preprint]. 2023 Jul 29:2023.07.26.550728. doi: 10.1101/2023.07.26.550728. bioRxiv. 2023. PMID: 37546995 Free PMC article. Preprint.
Repair Drive was well-tolerated and did not induce toxicity or tumorigenesis in long term follow up. This approach will broaden the range of liver diseases that can be treated with somatic genome editing....
Repair Drive was well-tolerated and did not induce toxicity or tumorigenesis in long term follow up. This approach will broaden the r …
Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation.
Grimm SL, Stading RE, Robertson MJ, Gandhi T, Fu C, Jiang W, Xia G, Lingappan K, Coarfa C, Moorthy B. Grimm SL, et al. Redox Biol. 2023 Aug;64:102790. doi: 10.1016/j.redox.2023.102790. Epub 2023 Jun 16. Redox Biol. 2023. PMID: 37348155 Free PMC article.
Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by triggering inflammation, with xenobiotic-metabolizing CYP enzymes playing a critical role. ...
Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by tr …
Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma.
Liu TW, Gammon ST, Yang P, Ma W, Wang J, Piwnica-Worms D. Liu TW, et al. J Immunother Cancer. 2023 Feb;11(2):e005837. doi: 10.1136/jitc-2022-005837. J Immunother Cancer. 2023. PMID: 36805920 Free PMC article.
Notably, repurposing MPO-specific inhibitors (verdiperstat, AZD5904) in combination with ICT pointedly enhanced response rates above ICT alone. Indeed, long-term survival was 100% in the YUMM3.3 melanoma model on treatment with verdiperstat plus ICT. ...
Notably, repurposing MPO-specific inhibitors (verdiperstat, AZD5904) in combination with ICT pointedly enhanced response rates above ICT alo …
Apoptosis of Hematopoietic Stem Cells Contributes to Bone Marrow Suppression Following Chimeric Antigen Receptor T Cell Therapy.
Read JA, Rouce RH, Mo F, Mamonkin M, King KY. Read JA, et al. Transplant Cell Ther. 2023 Mar;29(3):165.e1-165.e7. doi: 10.1016/j.jtct.2022.12.020. Epub 2022 Dec 31. Transplant Cell Ther. 2023. PMID: 36592718 Free PMC article.
Furthermore, HSPCs were found to have increased levels of apoptosis upon treatment with mIFN-gamma and mIL-6, whereas short-term HSCs and multipotent progenitors exhibited increases in proliferation with mIFN-gamma treatment alone. ...
Furthermore, HSPCs were found to have increased levels of apoptosis upon treatment with mIFN-gamma and mIL-6, whereas short-term HSCs …
100 results