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Year Number of Results
2009 2
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2011 4
2012 3
2013 9
2014 9
2015 7
2016 5
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2018 7
2019 10
2020 12
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2022 13
2023 9
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97 results

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Page 1
Generation of a humanized mAce2 and a conditional hACE2 mouse models permissive to SARS-COV-2 infection.
Song IW, Washington M, Leynes C, Hsu J, Rayavara K, Bae Y, Haelterman N, Chen Y, Jiang MM, Drelich A, Tat V, Lanza DG, Lorenzo I, Heaney JD, Tseng CK, Lee B, Marom R. Song IW, et al. Mamm Genome. 2024 Mar 15. doi: 10.1007/s00335-024-10033-8. Online ahead of print. Mamm Genome. 2024. PMID: 38488938
Development of pre-clinical animal models is critical to study viral-host interaction, tissue tropism, disease mechanisms, therapeutic approaches, and long-term sequelae of infection. Here, we report two mouse models for studying SARS-CoV-2: A knock-in mAce2(F83Y,H353K) mo …
Development of pre-clinical animal models is critical to study viral-host interaction, tissue tropism, disease mechanisms, therapeutic appro …
Dietary Folate and Cofactors Accelerate Age-dependent p16 Epimutation to Promote Intestinal Tumorigenesis.
Yang L, Peery RC, Farmer LM, Gao X, Zhang Y, Creighton CJ, Zhang L, Shen L. Yang L, et al. Cancer Res Commun. 2024 Jan 19;4(1):164-169. doi: 10.1158/2767-9764.CRC-23-0356. Cancer Res Commun. 2024. PMID: 38259096 Free PMC article.
SIGNIFICANCE: Our study demonstrates that dietary folate and cofactors modulate tumor-suppressor gene methylation to increase intestinal tumorigenesis. Our findings highlight the need for monitoring the long-term safety of folate fortification in high-risk individuals....
SIGNIFICANCE: Our study demonstrates that dietary folate and cofactors modulate tumor-suppressor gene methylation to increase intestinal tum …
Sex differences in paternal arsenic-induced intergenerational metabolic effects are mediated by estrogen.
Xue Y, Gong Y, Li X, Peng F, Ding G, Zhang Z, Shi J, Savul IS, Xu Y, Chen Q, Han L, Mao S, Sun Z. Xue Y, et al. Cell Biosci. 2023 Sep 10;13(1):165. doi: 10.1186/s13578-023-01121-4. Cell Biosci. 2023. PMID: 37691128 Free PMC article.
CONCLUSIONS: These results demonstrate that disrupted reproductive hormone secretion in alliance with hepatic estrogen signaling accounts for the sex-specific intergenerational effects of paternal iAs exposure, which shed light on the sex disparities in long-term gene-envi …
CONCLUSIONS: These results demonstrate that disrupted reproductive hormone secretion in alliance with hepatic estrogen signaling accounts fo …
In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene.
De Giorgi M, Park SH, Castoreno A, Cao M, Hurley A, Saxena L, Chuecos MA, Walkey CJ, Doerfler AM, Furgurson MN, Ljungberg MC, Patel KR, Hyde S, Chickering T, Lefebvre S, Wassarman K, Miller P, Qin J, Schlegel MK, Zlatev I, Li RG, Kim J, Martin JF, Bissig KD, Jadhav V, Bao G, Lagor WR. De Giorgi M, et al. bioRxiv [Preprint]. 2023 Jul 29:2023.07.26.550728. doi: 10.1101/2023.07.26.550728. bioRxiv. 2023. PMID: 37546995 Free PMC article. Preprint.
Repair Drive was well-tolerated and did not induce toxicity or tumorigenesis in long term follow up. This approach will broaden the range of liver diseases that can be treated with somatic genome editing....
Repair Drive was well-tolerated and did not induce toxicity or tumorigenesis in long term follow up. This approach will broaden the r …
Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation.
Grimm SL, Stading RE, Robertson MJ, Gandhi T, Fu C, Jiang W, Xia G, Lingappan K, Coarfa C, Moorthy B. Grimm SL, et al. Redox Biol. 2023 Aug;64:102790. doi: 10.1016/j.redox.2023.102790. Epub 2023 Jun 16. Redox Biol. 2023. PMID: 37348155 Free PMC article.
Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by triggering inflammation, with xenobiotic-metabolizing CYP enzymes playing a critical role. ...
Oxygen supplementation is life saving for premature infants and for COVID-19 patients but can induce long-term pulmonary injury by tr …
Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma.
Liu TW, Gammon ST, Yang P, Ma W, Wang J, Piwnica-Worms D. Liu TW, et al. J Immunother Cancer. 2023 Feb;11(2):e005837. doi: 10.1136/jitc-2022-005837. J Immunother Cancer. 2023. PMID: 36805920 Free PMC article.
Notably, repurposing MPO-specific inhibitors (verdiperstat, AZD5904) in combination with ICT pointedly enhanced response rates above ICT alone. Indeed, long-term survival was 100% in the YUMM3.3 melanoma model on treatment with verdiperstat plus ICT. ...
Notably, repurposing MPO-specific inhibitors (verdiperstat, AZD5904) in combination with ICT pointedly enhanced response rates above ICT alo …
Apoptosis of Hematopoietic Stem Cells Contributes to Bone Marrow Suppression Following Chimeric Antigen Receptor T Cell Therapy.
Read JA, Rouce RH, Mo F, Mamonkin M, King KY. Read JA, et al. Transplant Cell Ther. 2023 Mar;29(3):165.e1-165.e7. doi: 10.1016/j.jtct.2022.12.020. Epub 2022 Dec 31. Transplant Cell Ther. 2023. PMID: 36592718 Free PMC article.
Furthermore, HSPCs were found to have increased levels of apoptosis upon treatment with mIFN-gamma and mIL-6, whereas short-term HSCs and multipotent progenitors exhibited increases in proliferation with mIFN-gamma treatment alone. ...
Furthermore, HSPCs were found to have increased levels of apoptosis upon treatment with mIFN-gamma and mIL-6, whereas short-term HSCs …
Acute high-fat diet impairs macrophage-supported intestinal damage resolution.
Hill AA, Kim M, Zegarra-Ruiz DF, Chang LC, Norwood K, Assié A, Wu WH, Renfroe MC, Song HW, Major AM, Samuel BS, Hyser JM, Longman RS, Diehl GE. Hill AA, et al. JCI Insight. 2023 Feb 8;8(3):e164489. doi: 10.1172/jci.insight.164489. JCI Insight. 2023. PMID: 36538527 Free PMC article.
Chronic exposure to high-fat diets (HFD) worsens intestinal disease pathology, but acute effects of HFD in tissue damage remain unclear. Here, we used short-term HFD feeding in a model of intestinal injury and found sustained damage with increased cecal dead neutrophil acc …
Chronic exposure to high-fat diets (HFD) worsens intestinal disease pathology, but acute effects of HFD in tissue damage remain unclear. Her …
Germline Genetic and Treatment-Related Risk Factors for Diabetes Mellitus in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study and St Jude Lifetime Cohorts.
Richard MA, Mostoufi-Moab S, Rathore N, Baedke J, Brown AL, Chanock SJ, Friedman DN, Gramatges MM, Howell RM, Kamdar KY, Leisenring WM, Meacham LR, Morton LM, Oeffinger K, Robison LL, Sapkota Y, Sklar CA, Armstrong GT, Bhatia S, Lupo PJ. Richard MA, et al. JCO Precis Oncol. 2022 Dec;6:e2200239. doi: 10.1200/PO.22.00239. JCO Precis Oncol. 2022. PMID: 36480781 Free PMC article.
PURPOSE: To characterize germline genetic risk factors of diabetes mellitus among long-term survivors of childhood cancer. METHODS: Adult survivors of childhood cancer from the Childhood Cancer Survivor Study (CCSS) Original Cohort (n = 5,083; 383 with diabetes) were used …
PURPOSE: To characterize germline genetic risk factors of diabetes mellitus among long-term survivors of childhood cancer. METHODS: A …
Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction.
Kodali M, Madhu LN, Reger RL, Milutinovic B, Upadhya R, Gonzalez JJ, Attaluri S, Shuai B, Gitai DLG, Rao S, Choi JM, Jung SY, Shetty AK. Kodali M, et al. Brain Behav Immun. 2023 Feb;108:118-134. doi: 10.1016/j.bbi.2022.11.014. Epub 2022 Nov 24. Brain Behav Immun. 2023. PMID: 36427808 Free PMC article.
Inhibition of the chronic activation of NLRP3-p38/MAPK signaling after TBI also prevented long-term cognitive and mood impairments. Notably, the animals receiving higher doses of hMSC-EVs after TBI displayed better cognitive and mood function in all behavioral tests than a …
Inhibition of the chronic activation of NLRP3-p38/MAPK signaling after TBI also prevented long-term cognitive and mood impairments. N …
97 results