Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus.
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Forner S, et al.
Sci Rep. 2019 Nov 4;9(1):15936. doi: 10.1038/s41598-019-52324-0.
Sci Rep. 2019.
PMID: 31685865
Free PMC article.
We observed that expression of Abeta in both cellular compartments affect learning and memory, reduce the number of synapses and the expression of synaptic-related proteins, and disrupt chemical long-term potentiation (cLTP). Together, these findings indicate that during t …
We observed that expression of Abeta in both cellular compartments affect learning and memory, reduce the number of synapses and the express …