Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2005 2
2006 1
2007 1
2008 1
2009 1
2010 1
2012 3
2013 1
2015 2
2016 1
2017 4
2018 3
2019 4
2020 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

24 results

Results by year

Filters applied: . Clear all
Page 1
miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease.
Rodriguez-Ortiz CJ, Prieto GA, Martini AC, Forner S, Trujillo-Estrada L, LaFerla FM, Baglietto-Vargas D, Cotman CW, Kitazawa M. Rodriguez-Ortiz CJ, et al. Aging Cell. 2020 Mar;19(3):e13118. doi: 10.1111/acel.13118. Epub 2020 Feb 22. Aging Cell. 2020. PMID: 32087004 Free PMC article.
In primary hippocampal cultures, we found that an activity-dependent upregulation of the microRNA-regulating protein, translin, correlated with reduction of miR-181a upon chemical long-term potentiation (cLTP), which induced upregulation of GluA2, a predicted target for mi …
In primary hippocampal cultures, we found that an activity-dependent upregulation of the microRNA-regulating protein, translin, correlated w …
Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity.
Butler CW, Keiser AA, Kwapis JL, Berchtold NC, Wall VL, Wood MA, Cotman CW. Butler CW, et al. Learn Mem. 2019 Nov 15;26(12):485-492. doi: 10.1101/lm.050278.119. Print 2019 Dec. Learn Mem. 2019. PMID: 31732709 Free PMC article.
Here, we explore the effects of the duration of exercise and sedentary periods on long-term object location memory (OLM) in mice. We use a weak object location training paradigm that is subthreshold for long-term memory formation in sedentary controls, and demonstra …
Here, we explore the effects of the duration of exercise and sedentary periods on long-term object location memory (OLM) in mice. We …
Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus.
Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe CG, Cotman CW, Golde T, Baglietto-Vargas D, LaFerla FM. Forner S, et al. Sci Rep. 2019 Nov 4;9(1):15936. doi: 10.1038/s41598-019-52324-0. Sci Rep. 2019. PMID: 31685865 Free PMC article.
We observed that expression of Abeta in both cellular compartments affect learning and memory, reduce the number of synapses and the expression of synaptic-related proteins, and disrupt chemical long-term potentiation (cLTP). Together, these findings indicate that during t …
We observed that expression of Abeta in both cellular compartments affect learning and memory, reduce the number of synapses and the express …
Inhibition of LTP-Induced Translation by IL-1β Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites.
Prieto GA, Smith ED, Tong L, Nguyen M, Cotman CW. Prieto GA, et al. ACS Chem Neurosci. 2019 Mar 20;10(3):1197-1203. doi: 10.1021/acschemneuro.8b00511. Epub 2019 Feb 4. ACS Chem Neurosci. 2019. PMID: 30695637
In rodent hippocampus, the inflammatory cytokine interleukin-1beta (IL-1beta) impairs memory and long-term potentiation (LTP), a major form of plasticity that depends on protein synthesis. ...
In rodent hippocampus, the inflammatory cytokine interleukin-1beta (IL-1beta) impairs memory and long-term potentiation (LTP), a majo …
IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation.
Tong L, Prieto GA, Cotman CW. Tong L, et al. J Neuroinflammation. 2018 Apr 30;15(1):127. doi: 10.1186/s12974-018-1158-9. J Neuroinflammation. 2018. PMID: 29712570 Free PMC article.
BACKGROUND: Brain inflammation including increases in inflammatory cytokines such as IL-1beta is widely believed to contribute to the pathophysiology of Alzheimer's disease. Although IL-1beta-induced impairments in long-term potentiation (LTP) in acute hippocampal slices a …
BACKGROUND: Brain inflammation including increases in inflammatory cytokines such as IL-1beta is widely believed to contribute to the pathop …
TNFalpha and IL-1beta but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse.
Prieto GA, Tong L, Smith ED, Cotman CW. Prieto GA, et al. Neurochem Res. 2019 Jan;44(1):49-60. doi: 10.1007/s11064-018-2517-8. Epub 2018 Apr 4. Neurochem Res. 2019. PMID: 29619614 Free PMC article.
Research in animal models supports this connection by showing that inflammatory cytokines suppress long-term potentiation (LTP), the best-known cellular correlate of memory. ...Here, we evaluated the effect of a major set of inflammatory cytokines including tumor necrosis …
Research in animal models supports this connection by showing that inflammatory cytokines suppress long-term potentiation (LTP), the …
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease.
Sosna J, Philipp S, Albay R 3rd, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG. Sosna J, et al. Mol Neurodegener. 2018 Mar 1;13(1):11. doi: 10.1186/s13024-018-0244-x. Mol Neurodegener. 2018. PMID: 29490706 Free PMC article.
Directly after this treatment, we analyzed the amount of intraneuronal amyloid and neuritic plaques and performed behavioral studies including Y-maze, fear conditioning and elevated plus maze. RESULTS: We found that early long-term PLX3397 administration results in a drama …
Directly after this treatment, we analyzed the amount of intraneuronal amyloid and neuritic plaques and performed behavioral studies includi …
On the road towards the global analysis of human synapses.
Prieto GA, Cotman CW. Prieto GA, et al. Neural Regen Res. 2017 Oct;12(10):1586-1589. doi: 10.4103/1673-5374.217321. Neural Regen Res. 2017. PMID: 29171413 Free PMC article. Review.
In particular, using tissue from cryopreserved human brains, synaptic plasticity can be studied in isolated synaptosomes by fluorescence analysis of single-synapse long-term potentiation (FASS-LTP), and subpopulations of synapses can be thoroughly assessed in the ribbons o …
In particular, using tissue from cryopreserved human brains, synaptic plasticity can be studied in isolated synaptosomes by fluorescence ana …
Cytokines and cytokine networks target neurons to modulate long-term potentiation.
Prieto GA, Cotman CW. Prieto GA, et al. Cytokine Growth Factor Rev. 2017 Apr;34:27-33. doi: 10.1016/j.cytogfr.2017.03.005. Epub 2017 Mar 29. Cytokine Growth Factor Rev. 2017. PMID: 28377062 Free PMC article.
Cytokines play crucial roles in the communication between brain cells including neurons and glia, as well as in the brain-periphery interactions. In the brain, cytokines modulate long-term potentiation (LTP), a cellular correlate of memory. Whether cytokines regulate LTP b …
Cytokines play crucial roles in the communication between brain cells including neurons and glia, as well as in the brain-periphery interact …
HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease.
Marsh SE, Yeung ST, Torres M, Lau L, Davis JL, Monuki ES, Poon WW, Blurton-Jones M. Marsh SE, et al. Stem Cell Reports. 2017 Feb 14;8(2):235-248. doi: 10.1016/j.stemcr.2016.12.019. Stem Cell Reports. 2017. PMID: 28199828 Free PMC article.
However, AD is a protracted disorder, and prior studies have examined only short-term effects. We therefore used an immune-deficient model of AD (Rag-5xfAD mice) to examine long-term transplantation of human NSCs (StemCells Inc.; HuCNS-SCs). ...These data, while dis …
However, AD is a protracted disorder, and prior studies have examined only short-term effects. We therefore used an immune-deficient …
24 results