Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

29 results

Filters applied: . Clear all
Page 1
Prospective Long-term Follow-up of Focused Ultrasound Unilateral Subthalamotomy for Parkinson Disease.
Martínez-Fernández R, Natera-Villalba E, Máñez Miró JU, Rodriguez-Rojas R, Marta Del Álamo M, Pineda-Pardo JÁ, Ammann C, Obeso I, Mata-Marín D, Hernández-Fernández F, Gasca-Salas C, Matarazzo M, Alonso-Frech F, Obeso JA. Martínez-Fernández R, et al. Among authors: obeso ja. Neurology. 2023 Mar 28;100(13):e1395-e1405. doi: 10.1212/WNL.0000000000206771. Epub 2023 Jan 11. Neurology. 2023. PMID: 36631272 Free PMC article. Clinical Trial.
Whether this effect is sustained is not known. This study aims to report the long-term outcome of patients with PD treated with unilateral FUS-STN. ...DISCUSSION: The benefit of unilateral FUS-STN on PD motor features is sustained in the long term. FUS-STN contribut …
Whether this effect is sustained is not known. This study aims to report the long-term outcome of patients with PD treated with unila …
Long-term effect of unilateral subthalamotomy for Parkinson's disease.
Ricardo Y, Pavon N, Alvarez L, Casabona E, Teijeiro J, Díaz A, Maragoto C, Pedroso I, Garcia-Maeso I, Máñez-Miró JU, Martinez-Fernandez R, Macias R, Obeso JA. Ricardo Y, et al. Among authors: obeso ja. J Neurol Neurosurg Psychiatry. 2019 Dec;90(12):1380-1381. doi: 10.1136/jnnp-2019-320523. Epub 2019 May 13. J Neurol Neurosurg Psychiatry. 2019. PMID: 31085584 No abstract available.
Motor complications in Parkinson's disease: Striatal molecular and electrophysiological mechanisms of dyskinesias.
Picconi B, Hernández LF, Obeso JA, Calabresi P. Picconi B, et al. Among authors: obeso ja. Mov Disord. 2018 Jul;33(6):867-876. doi: 10.1002/mds.27261. Epub 2017 Dec 8. Mov Disord. 2018. PMID: 29219207 Review.
Long-term levodopa (l-dopa) treatment in patients with Parkinsons disease (PD) is associated with the development of motor complications (ie, motor fluctuations and dyskinesias). ...
Long-term levodopa (l-dopa) treatment in patients with Parkinsons disease (PD) is associated with the development of motor complicati …
Short- and long-term effects induced by repeated 6-OHDA intraventricular administration: A new progressive and bilateral rodent model of Parkinson's disease.
Quiroga-Varela A, Aguilar E, Iglesias E, Obeso JA, Marin C. Quiroga-Varela A, et al. Among authors: obeso ja. Neuroscience. 2017 Oct 11;361:144-156. doi: 10.1016/j.neuroscience.2017.08.017. Epub 2017 Aug 18. Neuroscience. 2017. PMID: 28823819
To find a convenient rat model for studying the progression of dopaminergic cell degeneration and motor signs, we have developed a progressive rodent model using a repeated daily, intraventricular administration of the neurotoxin 6-hydroxydopamine (6-OHDA) (100g/day) in awakened …
To find a convenient rat model for studying the progression of dopaminergic cell degeneration and motor signs, we have developed a progressi …
Parkinson's disease with mild cognitive impairment: severe cortical thinning antedates dementia.
Gasca-Salas C, García-Lorenzo D, Garcia-Garcia D, Clavero P, Obeso JA, Lehericy S, Rodríguez-Oroz MC. Gasca-Salas C, et al. Among authors: obeso ja. Brain Imaging Behav. 2019 Feb;13(1):180-188. doi: 10.1007/s11682-017-9751-6. Brain Imaging Behav. 2019. PMID: 28710667
The cortex of PD-MCI converters was thinner than that of PD-MCI non-converters, bilaterally in the frontal, insula and the left middle temporal areas, also displaying a more widespread pattern of cortical thinning relative to the controls. This study shows that aged and long-t …
The cortex of PD-MCI converters was thinner than that of PD-MCI non-converters, bilaterally in the frontal, insula and the left middle tempo …
Striatal activation by optogenetics induces dyskinesias in the 6-hydroxydopamine rat model of Parkinson disease.
F Hernández L, Castela I, Ruiz-DeDiego I, Obeso JA, Moratalla R. F Hernández L, et al. Among authors: obeso ja. Mov Disord. 2017 Apr;32(4):530-537. doi: 10.1002/mds.26947. Epub 2017 Mar 3. Mov Disord. 2017. PMID: 28256089
BACKGROUND: Long-term levodopa (l-dopa) treatment is associated with the development of l-dopa-induced dyskinesias in the majority of patients with Parkinson disease (PD). ...
BACKGROUND: Long-term levodopa (l-dopa) treatment is associated with the development of l-dopa-induced dyskinesias in the majority of …
Current applications and limitations of surgical treatments for movement disorders.
Krack P, Martinez-Fernandez R, Del Alamo M, Obeso JA. Krack P, et al. Among authors: obeso ja. Mov Disord. 2017 Jan;32(1):36-52. doi: 10.1002/mds.26890. Mov Disord. 2017. PMID: 28124435 Review.
Although deep brain stimulation is accepted worldwide and technical advances continue to improve this therapy, new questions and challenges such as long-term benefits and optimal targeting have emerged. In addition, new nonincisional tools used to perform ablative treatmen …
Although deep brain stimulation is accepted worldwide and technical advances continue to improve this therapy, new questions and challenges …
The end of the term.
Olanow CW, Obeso JA. Olanow CW, et al. Among authors: obeso ja. Mov Disord. 2014 Dec;29(14):1703-4. doi: 10.1002/mds.26106. Mov Disord. 2014. PMID: 25487521 No abstract available.
Early L-dopa, but not pramipexole, restores basal ganglia activity in partially 6-OHDA-lesioned rats.
Marin C, Bonastre M, Mengod G, Cortés R, Giralt A, Obeso JA, Schapira AH. Marin C, et al. Among authors: obeso ja. Neurobiol Dis. 2014 Apr;64:36-47. doi: 10.1016/j.nbd.2013.12.009. Epub 2013 Dec 24. Neurobiol Dis. 2014. PMID: 24370700
It has been suggested that early correction of basal ganglia pathophysiological abnormalities may have long-term beneficial effects. To test this hypothesis, we investigated the early and delayed actions of L-dopa and pramipexole, using a delayed-start protocol of treatmen …
It has been suggested that early correction of basal ganglia pathophysiological abnormalities may have long-term beneficial effects. …
l-dopa-induced dyskinesias in unilateral 6-hydroxydopamine-lesioned rats are not modified by excitotoxic lesion of the entopeduncular nucleus and substantia nigra pars reticulata.
Gago B, Marin C, Rodríguez-Oroz MC, Obeso JA. Gago B, et al. Among authors: obeso ja. Synapse. 2013 Jul;67(7):407-14. doi: 10.1002/syn.21652. Epub 2013 Apr 2. Synapse. 2013. PMID: 23404474
l-Dopa-induced dyskinesias (LIDs) are a troublesome complication in Parkinson's disease after long-term therapy and a major reason for surgical treatment. LIDs are effectively eliminated by surgery. ...
l-Dopa-induced dyskinesias (LIDs) are a troublesome complication in Parkinson's disease after long-term therapy and a major reason fo …
29 results