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Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies.
Biochem J. 2014 Aug 1;461(3):413-26. doi: 10.1042/BJ20140219.
Biochem J. 2014.
PMID: 24785004
We showed that similar to monomers, unaggregated dimers lack appreciable structure and fail to alter long-term potentiation. Importantly, dimers exhibit subtly different structural propensities from monomers and each other, and can self-associate to form larger assemblies. …
We showed that similar to monomers, unaggregated dimers lack appreciable structure and fail to alter long-term potentiation. Importan …
A monoclonal antibody against synthetic Aβ dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aβ.
O'Nuallain B, Klyubin I, Mc Donald JM, Foster JS, Welzel A, Barry A, Dykoski RK, Cleary JP, Gebbink MF, Rowan MJ, Walsh DM.
O'Nuallain B, et al.
J Neurochem. 2011 Oct;119(1):189-201. doi: 10.1111/j.1471-4159.2011.07389.x. Epub 2011 Aug 22.
J Neurochem. 2011.
PMID: 21781116
Free PMC article.
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Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils.
O'Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, Herron CE, Collinge J, Walsh DM.
O'Nuallain B, et al.
J Neurosci. 2010 Oct 27;30(43):14411-9. doi: 10.1523/JNEUROSCI.3537-10.2010.
J Neurosci. 2010.
PMID: 20980598
Free PMC article.
Aqueous extracts of human brain contain Abeta assemblies that migrate on SDS-polyacrylamide gels and elute from size exclusion as dimers (8 kDa) and can block long-term potentiation and impair memory consolidation in the rat. Such species are detected specifically and sens …
Aqueous extracts of human brain contain Abeta assemblies that migrate on SDS-polyacrylamide gels and elute from size exclusion as dimers (8 …
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Inherent anti-amyloidogenic activity of human immunoglobulin gamma heavy chains.
Adekar SP, Klyubin I, Macy S, Rowan MJ, Solomon A, Dessain SK, O'Nuallain B.
Adekar SP, et al. Among authors: o nuallain b.
J Biol Chem. 2010 Jan 8;285(2):1066-74. doi: 10.1074/jbc.M109.044321. Epub 2009 Nov 4.
J Biol Chem. 2010.
PMID: 19889627
Free PMC article.
Most importantly, the F1 heavy chain prevented in vitro fibril growth and reduced in vivo soluble Abeta oligomer-induced impairment of rodent hippocampal long term potentiation, a cellular mechanism of learning and memory. These findings demonstrate that free human Ig gamm …
Most importantly, the F1 heavy chain prevented in vitro fibril growth and reduced in vivo soluble Abeta oligomer-induced impairment of roden …
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