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Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies.
O'Malley TT, Oktaviani NA, Zhang D, Lomakin A, O'Nuallain B, Linse S, Benedek GB, Rowan MJ, Mulder FA, Walsh DM. O'Malley TT, et al. Among authors: o nuallain b. Biochem J. 2014 Aug 1;461(3):413-26. doi: 10.1042/BJ20140219. Biochem J. 2014. PMID: 24785004
We showed that similar to monomers, unaggregated dimers lack appreciable structure and fail to alter long-term potentiation. Importantly, dimers exhibit subtly different structural propensities from monomers and each other, and can self-associate to form larger assemblies. …
We showed that similar to monomers, unaggregated dimers lack appreciable structure and fail to alter long-term potentiation. Importan …
Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils.
O'Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, Herron CE, Collinge J, Walsh DM. O'Nuallain B, et al. J Neurosci. 2010 Oct 27;30(43):14411-9. doi: 10.1523/JNEUROSCI.3537-10.2010. J Neurosci. 2010. PMID: 20980598 Free PMC article.
Aqueous extracts of human brain contain Abeta assemblies that migrate on SDS-polyacrylamide gels and elute from size exclusion as dimers (8 kDa) and can block long-term potentiation and impair memory consolidation in the rat. Such species are detected specifically and sens …
Aqueous extracts of human brain contain Abeta assemblies that migrate on SDS-polyacrylamide gels and elute from size exclusion as dimers (8 …
Inherent anti-amyloidogenic activity of human immunoglobulin gamma heavy chains.
Adekar SP, Klyubin I, Macy S, Rowan MJ, Solomon A, Dessain SK, O'Nuallain B. Adekar SP, et al. Among authors: o nuallain b. J Biol Chem. 2010 Jan 8;285(2):1066-74. doi: 10.1074/jbc.M109.044321. Epub 2009 Nov 4. J Biol Chem. 2010. PMID: 19889627 Free PMC article.
Most importantly, the F1 heavy chain prevented in vitro fibril growth and reduced in vivo soluble Abeta oligomer-induced impairment of rodent hippocampal long term potentiation, a cellular mechanism of learning and memory. These findings demonstrate that free human Ig gamm …
Most importantly, the F1 heavy chain prevented in vitro fibril growth and reduced in vivo soluble Abeta oligomer-induced impairment of roden …