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Circulating Docosahexaenoic Acid and Risk of All-Cause and Cause-Specific Mortality.
O'Keefe EL, O'Keefe JH, Tintle NL, Westra J, Albuisson L, Harris WS. O'Keefe EL, et al. Among authors: o keefe jh. Mayo Clin Proc. 2024 Apr;99(4):534-541. doi: 10.1016/j.mayocp.2023.11.026. Epub 2024 Mar 20. Mayo Clin Proc. 2024. PMID: 38506781 Free article.
OBJECTIVE: To assess the associations of docosahexaenoic acid (DHA), a marine omega-3 fatty acid, with long-term all-cause mortality, cardiovascular (CV) mortality, and cancer mortality. ...
OBJECTIVE: To assess the associations of docosahexaenoic acid (DHA), a marine omega-3 fatty acid, with long-term all-cause mortality, …
Training Strategies to Optimize Cardiovascular Durability and Life Expectancy.
O'Keefe JH, O'Keefe EL, Eckert R, Lavie CJ. O'Keefe JH, et al. Mo Med. 2023 Mar-Apr;120(2):155-162. Mo Med. 2023. PMID: 37091937 Free PMC article.
The purpose of this article is to review the recent literature on the effects of duration and intensity of exercise, physical fitness, and specific types of training/sports on long-term CV health and life expectancy. A systematic review of recent studies (2011 to 2022) was …
The purpose of this article is to review the recent literature on the effects of duration and intensity of exercise, physical fitness, and s …
Could Repeated Cardio-Renal Injury Trigger Late Cardiovascular Sequelae in Extreme Endurance Athletes?
Burtscher J, Vanderriele PE, Legrand M, Predel HG, Niebauer J, O'Keefe JH, Millet GP, Burtscher M. Burtscher J, et al. Among authors: o keefe jh. Sports Med. 2022 Dec;52(12):2821-2836. doi: 10.1007/s40279-022-01734-8. Epub 2022 Jul 18. Sports Med. 2022. PMID: 35851948 Free PMC article. Review.
This has raised concerns that chronic recurring insults could cause long-term cardiac and/or renal damage. Indeed, extreme endurance exercise (EEE) over decades has sometimes been linked with untoward cardiac effects, but a causal relation with acute injury markers has not …
This has raised concerns that chronic recurring insults could cause long-term cardiac and/or renal damage. Indeed, extreme endurance …
Cardiovascular Effects of ADHD Therapies: JACC Review Topic of the Week.
Torres-Acosta N, O'Keefe JH, O'Keefe CL, Lavie CJ. Torres-Acosta N, et al. Among authors: o keefe jh. J Am Coll Cardiol. 2020 Aug 18;76(7):858-866. doi: 10.1016/j.jacc.2020.05.081. J Am Coll Cardiol. 2020. PMID: 32792083 Free article.
However, such reports did not imply causation, and there was a paucity of randomized trial evidence addressing long-term safety of ADHD medications, particularly among adults. Further studies are essential to clarify the risks and benefits of ADHD stimulant medications and …
However, such reports did not imply causation, and there was a paucity of randomized trial evidence addressing long-term safety of AD …
Alzheimer's "Prevention" vs. "Risk Reduction": Transcending Semantics for Clinical Practice.
Hodes JF, Oakley CI, O'Keefe JH, Lu P, Galvin JE, Saif N, Bellara S, Rahman A, Kaufman Y, Hristov H, Rajji TK, Fosnacht Morgan AM, Patel S, Merrill DA, Kaiser S, Meléndez-Cabrero J, Melendez JA, Krikorian R, Isaacson RS. Hodes JF, et al. Among authors: o keefe jh. Front Neurol. 2019 Jan 21;9:1179. doi: 10.3389/fneur.2018.01179. eCollection 2018. Front Neurol. 2019. PMID: 30719021 Free PMC article.
While prior studies have codified research-based criteria for the progressive stages of AD, there are no clear clinical consensus criteria to guide the use of these terms for physicians in practice. A clear understanding of the implications of each term will help guide cli …
While prior studies have codified research-based criteria for the progressive stages of AD, there are no clear clinical consensus criteria t …
The Goldilocks Zone for Exercise: Not Too Little, Not Too Much.
O'Keefe JH, O'Keefe EL, Lavie CJ. O'Keefe JH, et al. Mo Med. 2018 Mar-Apr;115(2):98-105. Mo Med. 2018. PMID: 30228692 Free PMC article.
An emerging body of evidence indicates U-shaped or reverse J-shaped curves whereby low doses and moderate doses of PA significantly reduce long-term risks for both total mortality and CV mortality, however, at very high doses of chronic strenuous exercise much of the prote …
An emerging body of evidence indicates U-shaped or reverse J-shaped curves whereby low doses and moderate doses of PA significantly reduce l …
Coffee for Cardioprotection and Longevity.
O'Keefe JH, DiNicolantonio JJ, Lavie CJ. O'Keefe JH, et al. Prog Cardiovasc Dis. 2018 May-Jun;61(1):38-42. doi: 10.1016/j.pcad.2018.02.002. Epub 2018 Feb 21. Prog Cardiovasc Dis. 2018. PMID: 29474816 Review.
Coffee, a complex brew containing hundreds of biologically active compounds, exerts potent effects on long-term human health. Recently, a plethora of studies have been published focusing on health outcomes associated with coffee intake. ...Coffee may also increase risk of …
Coffee, a complex brew containing hundreds of biologically active compounds, exerts potent effects on long-term human health. Recentl …
Alcohol and CV Health: Jekyll and Hyde J-Curves.
O'Keefe EL, DiNicolantonio JJ, O'Keefe JH, Lavie CJ. O'Keefe EL, et al. Among authors: o keefe jh. Prog Cardiovasc Dis. 2018 May-Jun;61(1):68-75. doi: 10.1016/j.pcad.2018.02.001. Epub 2018 Feb 16. Prog Cardiovasc Dis. 2018. PMID: 29458056 Review.
Red wine in particular before or during the evening meal is linked with the best long-term CV outcomes. Most of the studies on alcohol and health are observational, and correlation does not prove causation. ...
Red wine in particular before or during the evening meal is linked with the best long-term CV outcomes. Most of the studies on alcoho …
Insulin Therapy Increases Cardiovascular Risk in Type 2 Diabetes.
Herman ME, O'Keefe JH, Bell DSH, Schwartz SS. Herman ME, et al. Among authors: o keefe jh. Prog Cardiovasc Dis. 2017 Nov-Dec;60(3):422-434. doi: 10.1016/j.pcad.2017.09.001. Epub 2017 Sep 25. Prog Cardiovasc Dis. 2017. PMID: 28958751 Review.
These associations support the findings of large-scale evaluations that strongly suggest that insulin therapy has a poorer short- and long-term safety profile than that found to many other anti-T2D therapies. ...
These associations support the findings of large-scale evaluations that strongly suggest that insulin therapy has a poorer short- and long- …
Nutritional strategies for skeletal and cardiovascular health: hard bones, soft arteries, rather than vice versa.
O'Keefe JH, Bergman N, Carrera-Bastos P, Fontes-Villalba M, DiNicolantonio JJ, Cordain L. O'Keefe JH, et al. Open Heart. 2016 Mar 22;3(1):e000325. doi: 10.1136/openhrt-2015-000325. eCollection 2016. Open Heart. 2016. PMID: 27042317 Free PMC article. Review.
We comprehensively and systematically reviewed the scientific literature in order to determine the optimal dietary strategies and nutritional supplements for long-term skeletal health and cardiovascular health. To summarise, the following steps may be helpful for building …
We comprehensively and systematically reviewed the scientific literature in order to determine the optimal dietary strategies and nutritiona …
33 results