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Inflammatory and immune markers in HIV-infected older adults on long-term antiretroviral therapy: Persistent elevation of sCD14 and of proinflammatory effector memory T cells.
Watanabe M, Jergovic M, Davidson L, LaFleur BJ, Castaneda Y, Martinez C, Smithey MJ, Stowe RP, Haddad EK, Nikolich-Žugich J. Watanabe M, et al. Among authors: nikolich zugich j. Aging Cell. 2022 Sep;21(9):e13681. doi: 10.1111/acel.13681. Epub 2022 Aug 16. Aging Cell. 2022. PMID: 35975357 Free PMC article.
Here, we tested whether the immune correlates of aging, including cell numbers and phenotypes, inflammatory status, and control of human cytomegalovirus (hCMV) in HIV-positive subjects on long-term successful ART (HIV+) may reveal increased "immunological age" compared wit …
Here, we tested whether the immune correlates of aging, including cell numbers and phenotypes, inflammatory status, and control of human cyt …
Competent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccination.
Jergović M, Uhrlaub JL, Watanabe M, Bradshaw CM, White LM, LaFleur BJ, Edwards T, Sprissler R, Worobey M, Bhattacharya D, Nikolich-Žugich J. Jergović M, et al. Among authors: nikolich zugich j. Nat Commun. 2022 May 24;13(1):2891. doi: 10.1038/s41467-022-30617-9. Nat Commun. 2022. PMID: 35610270 Free PMC article.
More specifically, the older cohort has lower neutralizing capacity at 7-14 days following the second dose but equilibrates with the younger cohort after 2-3 months. While long-term vaccination responses remain to be determined, our results implicate vaccine-induced protec …
More specifically, the older cohort has lower neutralizing capacity at 7-14 days following the second dose but equilibrates with the younger …
Infection-induced type I interferons critically modulate the homeostasis and function of CD8+ naïve T cells.
Jergović M, Coplen CP, Uhrlaub JL, Besselsen DG, Cheng S, Smithey MJ, Nikolich-Žugich J. Jergović M, et al. Among authors: nikolich zugich j. Nat Commun. 2021 Sep 6;12(1):5303. doi: 10.1038/s41467-021-25645-w. Nat Commun. 2021. PMID: 34489451 Free PMC article.
Naive T (Tn) cells require two homeostatic signals for long-term survival: tonic T cell receptor:self-peptide-MHC contact and IL-7 stimulation. ...
Naive T (Tn) cells require two homeostatic signals for long-term survival: tonic T cell receptor:self-peptide-MHC contact and IL-7 st …
Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution.
Contreras NA, Fontana L, Tosti V, Nikolich-Žugich J. Contreras NA, et al. Among authors: nikolich zugich j. Geroscience. 2018 Jun;40(3):279-291. doi: 10.1007/s11357-018-0022-2. Epub 2018 May 26. Geroscience. 2018. PMID: 29804201 Free PMC article.
However, the global consequences of CR followed by refeeding on the immune system have not been carefully investigated. Here, we show that individuals practicing long-term CR with adequate nutrition have markedly lower circulating levels of total leukocytes, neutrophils, l …
However, the global consequences of CR followed by refeeding on the immune system have not been carefully investigated. Here, we show that i …
The Contribution of Cytomegalovirus Infection to Immune Senescence Is Set by the Infectious Dose.
Redeker A, Remmerswaal EBM, van der Gracht ETI, Welten SPM, Höllt T, Koning F, Cicin-Sain L, Nikolich-Žugich J, Ten Berge IJM, van Lier RAW, van Unen V, Arens R. Redeker A, et al. Among authors: nikolich zugich j. Front Immunol. 2018 Jan 10;8:1953. doi: 10.3389/fimmu.2017.01953. eCollection 2017. Front Immunol. 2018. PMID: 29367854 Free PMC article.
Detailed cluster analysis of the memory CD8(+) T cell development showed that high-dose infection causes a differentiation pathway that progresses faster throughout the life span of the host, suggesting a virus-host balance that is influenced by aging and infectious dose. Importa …
Detailed cluster analysis of the memory CD8(+) T cell development showed that high-dose infection causes a differentiation pathway that prog …
Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques.
Okoye AA, Rohankhedkar M, Konfe AL, Abana CO, Reyes MD, Clock JA, Duell DM, Sylwester AW, Sammader P, Legasse AW, Park BS, Axthelm MK, Nikolich-Žugich J, Picker LJ. Okoye AA, et al. Among authors: nikolich zugich j. J Immunol. 2015 Nov 1;195(9):4292-305. doi: 10.4049/jimmunol.1500609. Epub 2015 Sep 28. J Immunol. 2015. PMID: 26416281 Free PMC article.
Our results indicate that treatment of both adult (8-15 y) and old (>20 y) RM with recombinant simian IL-7 (rsIL-7) results in only transient increases in peripheral CD4(+) and CD8(+) TN numbers with no long-term benefit, even with repeated therapy. This transient effec …
Our results indicate that treatment of both adult (8-15 y) and old (>20 y) RM with recombinant simian IL-7 (rsIL-7) results in only trans …
Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections.
Goldberg EL, Smithey MJ, Lutes LK, Uhrlaub JL, Nikolich-Žugich J. Goldberg EL, et al. Among authors: nikolich zugich j. J Immunol. 2014 Jul 15;193(2):757-63. doi: 10.4049/jimmunol.1400188. Epub 2014 Jun 9. J Immunol. 2014. PMID: 24913978 Free PMC article.
Direct mammalian target of rapamycin (Rapa) complex 1 inhibition by short-term low-dose Rapa treatment has recently been shown to improve CD8 T cell immunological memory. ...
Direct mammalian target of rapamycin (Rapa) complex 1 inhibition by short-term low-dose Rapa treatment has recently been shown to imp …
Translational research in immune senescence: assessing the relevance of current models.
High KP, Akbar AN, Nikolich-Zugich J. High KP, et al. Among authors: nikolich zugich j. Semin Immunol. 2012 Oct;24(5):373-82. doi: 10.1016/j.smim.2012.04.007. Epub 2012 May 23. Semin Immunol. 2012. PMID: 22633440 Free PMC article. Review.
Advancing age is accompanied by profound changes in immune function; some are induced by the loss of critical niches that support development of naive cells (e.g. thymic involution), others by the intrinsic physiology of long-lived cells attempting to maintain homeostasis, still …
Advancing age is accompanied by profound changes in immune function; some are induced by the loss of critical niches that support developmen …
Age-related dysregulation of CD8+ T cell memory specific for a persistent virus is independent of viral replication.
Lang A, Brien JD, Messaoudi I, Nikolich-Zugich J. Lang A, et al. Among authors: nikolich zugich j. J Immunol. 2008 Apr 1;180(7):4848-57. doi: 10.4049/jimmunol.180.7.4848. J Immunol. 2008. PMID: 18354208 Free PMC article.
But neither the causality nor the mechanistic link(s) were established, and the relative roles of persistent antigenic stimulation and of virus-independent homeostatic disturbances in T cell aging remain unresolved. We longitudinally analyzed expansion, contraction, and long-t …
But neither the causality nor the mechanistic link(s) were established, and the relative roles of persistent antigenic stimulation and of vi …
13 results