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Lanadelumab demonstrates rapid and sustained prevention of hereditary angioedema attacks.
Riedl MA, Maurer M, Bernstein JA, Banerji A, Longhurst HJ, Li HH, Lu P, Hao J, Juethner S, Lumry WR; HELP Investigators. Riedl MA, et al. Allergy. 2020 Nov;75(11):2879-2887. doi: 10.1111/all.14416. Epub 2020 Jul 6. Allergy. 2020. PMID: 32452549 Free PMC article. Clinical Trial.
BACKGROUND: Lanadelumab demonstrated efficacy in preventing hereditary angioedema (HAE) attacks in the phase 3 HELP Study. OBJECTIVE: To assess time to onset of effect and long-term efficacy of lanadelumab, based on exploratory findings from the HELP Study. ...
BACKGROUND: Lanadelumab demonstrated efficacy in preventing hereditary angioedema (HAE) attacks in the phase 3 HELP Study. OBJECTIVE: To ass …
Fixed-Dose Subcutaneous C1-Inhibitor Liquid for Prophylactic Treatment of C1-INH-HAE: SAHARA Randomized Study.
Lumry WR, Martinez-Saguer I, Yang WH, Bernstein JA, Jacobs J, Moldovan D, Riedl MA, Johnston DT, Li HH, Tang Y, Schranz J, Lu P, Vardi M, Farkas H; SAHARA study group. Lumry WR, et al. J Allergy Clin Immunol Pract. 2019 May-Jun;7(5):1610-1618.e4. doi: 10.1016/j.jaip.2019.01.021. Epub 2019 Jan 23. J Allergy Clin Immunol Pract. 2019. PMID: 30682573 Free article. Clinical Trial.
METHODS: Eligible patients were 12 years with 2 monthly attacks prescreening or pre-long-term prophylaxis. In a partial crossover design, 80% of patients were randomized to placebo or pdC1-INH liquid for 14 weeks and crossed over from active to placebo or vice versa for an …
METHODS: Eligible patients were 12 years with 2 monthly attacks prescreening or pre-long-term prophylaxis. In a partial crossover des …
A single German center experience with intermittent inotropes for patients on the high-urgent heart transplant waiting list.
Hübner T, Nickel T, Steinbeck G, Massberg S, Schramm R, Reichart B, Hagl C, Kiwi A, Weis M. Hübner T, et al. Among authors: nickel t. Clin Res Cardiol. 2015 Nov;104(11):929-34. doi: 10.1007/s00392-015-0852-1. Epub 2015 Apr 5. Clin Res Cardiol. 2015. PMID: 25841881 Clinical Trial.
All patients on the Eurotransplant high-urgent status (HU) have to be treated in intensive care units and have to be relisted every 8 weeks. Long-term continuous inotropes are associated with tachyphylaxia, arrhythmias and even increased mortality. ...
All patients on the Eurotransplant high-urgent status (HU) have to be treated in intensive care units and have to be relisted every 8 weeks. …
Gender-based analysis of outcome after heart transplantation.
Eifert S, Kofler S, Nickel T, Horster S, Bigdeli AK, Beiras-Fernandez A, Meiser B, Kaczmarek I. Eifert S, et al. Among authors: nickel t. Exp Clin Transplant. 2012 Aug;10(4):368-74. doi: 10.6002/ect.2011.0164. Exp Clin Transplant. 2012. PMID: 22845767 Free article.
Multivariate analysis showed that the gender combination with female donors and female recipients was an independent indicator for greater long-term survival (P = .04). CONCLUSIONS: The gender combination of female donors and male recipients had a greater risk for early mo …
Multivariate analysis showed that the gender combination with female donors and female recipients was an independent indicator for greater l …
Modification of endothelial biology by acute and chronic stress hormones.
Nickel T, Deutschmann A, Hanssen H, Summo C, Wilbert-Lampen U. Nickel T, et al. Microvasc Res. 2009 Dec;78(3):364-9. doi: 10.1016/j.mvr.2009.07.008. Epub 2009 Aug 5. Microvasc Res. 2009. PMID: 19664643
RESULTS: With respect to analysed acute and chronic stress hormones, ET-1 release was significantly increased. Likewise, protein expression was enhanced after long term incubation (24 h) with norepinephrine and dexamethasone. In contrast, endothelial NO-levels were only in …
RESULTS: With respect to analysed acute and chronic stress hormones, ET-1 release was significantly increased. Likewise, protein expression …
Dendritic cells as pharmacological targets for the generation of regulatory immunosuppressive effectors. New implications for allo-transplantation.
Schlichting CL, Schareck WD, Nickel T, Weis M. Schlichting CL, et al. Among authors: nickel t. Curr Med Chem. 2005;12(16):1921-30. doi: 10.2174/0929867054546627. Curr Med Chem. 2005. PMID: 16101510 Review.
Seemingly, it depends on the DC maturation state whether pharmacologically modulated DCs induce antigen specific long-term tolerance in allo-transplantation solid organ transplantation. ...
Seemingly, it depends on the DC maturation state whether pharmacologically modulated DCs induce antigen specific long-term tolerance …
Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. a prospective study.
Zobel AW, Nickel T, Sonntag A, Uhr M, Holsboer F, Ising M. Zobel AW, et al. Among authors: nickel t. J Psychiatr Res. 2001 Mar-Apr;35(2):83-94. doi: 10.1016/s0022-3956(01)00013-9. J Psychiatr Res. 2001. PMID: 11377437
Previous research documented that the combined dexamethasone/corticotropin-releasing hormone (DEX/CRH) test identifies HPA dysfunction with high sensitivity. We evaluated the predictive validity for medium-term outcome of the cortisol response in the combined DEX/CRH test …
Previous research documented that the combined dexamethasone/corticotropin-releasing hormone (DEX/CRH) test identifies HPA dysfunction with …