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Association Between Early External Ventricular Drain Insertion and Functional Outcomes 6 Months Following Moderate-to-Severe Traumatic Brain Injury.
Taylor JD, Bailey M, Cooper DJ, French C, Menon DK, Nichol AD, Pisică D, Udy A, Volovici V, Higgins AM. Taylor JD, et al. Among authors: nichol ad. J Neurotrauma. 2024 Feb 16. doi: 10.1089/neu.2023.0493. Online ahead of print. J Neurotrauma. 2024. PMID: 38279804
Our study suggests that in patients with m-sTBI where an EVD is needed, early ( 24 h post-injury) insertion may result in better long-term functional outcomes. This finding supports future prospective investigation in this area....
Our study suggests that in patients with m-sTBI where an EVD is needed, early ( 24 h post-injury) insertion may result in better long-ter …
Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study.
Battaglini D, White NM, Premraj L, Wanjiru Citarella B, Merson L, Robba C, Thomson D, Cho SM; ISARIC Clinical Characterization Group. Battaglini D, et al. J Neurol. 2024 Jan;271(1):79-86. doi: 10.1007/s00415-023-12133-y. Epub 2023 Dec 6. J Neurol. 2024. PMID: 38055020 Free PMC article. No abstract available.
A multi-country analysis of COVID-19 hospitalizations by vaccination status.
Gonçalves BP, Jassat W, Baruch J, Hashmi M, Rojek A, Dasgupta A, Martin-Loeches I, Reyes LF, Piubelli C, Citarella BW, Kartsonaki C, Lefèvre B, López Revilla JW, Lunn M, Harrison EM, Kraemer MUG, Shrapnel S, Horby P, Bisoffi Z, Olliaro PL, Merson L; ISARIC Clinical Characterisation Group. Gonçalves BP, et al. Med. 2023 Nov 10;4(11):797-812.e2. doi: 10.1016/j.medj.2023.08.005. Epub 2023 Sep 21. Med. 2023. PMID: 37738979 Free PMC article.
CONCLUSIONS: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. ...
CONCLUSIONS: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term internat …
Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial.
Writing Committee for the REMAP-CAP Investigators; Higgins AM, Berry LR, Lorenzi E, Murthy S, McQuilten Z, Mouncey PR, Al-Beidh F, Annane D, Arabi YM, Beane A, van Bentum-Puijk W, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Burrell A, Buzgau A, Buxton M, Charles WN, Cove M, Detry MA, Estcourt LJ, Fagbodun EO, Fitzgerald M, Girard TD, Goligher EC, Goossens H, Haniffa R, Hills T, Horvat CM, Huang DT, Ichihara N, Lamontagne F, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Neal MD, Nichol AD, Parke RL, Parker JC, Parry-Billings K, Peters SEC, Reyes LF, Rowan KM, Saito H, Santos MS, Saunders CT, Serpa-Neto A, Seymour CW, Shankar-Hari M, Stronach LM, Turgeon AF, Turner AM, van de Veerdonk FL, Zarychanski R, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Derde LPG, Gordon AC, Webb SA, Lawler PR. Writing Committee for the REMAP-CAP Investigators, et al. Among authors: nichol ad. JAMA. 2023 Jan 3;329(1):39-51. doi: 10.1001/jama.2022.23257. JAMA. 2023. PMID: 36525245 Free PMC article.
IMPORTANCE: The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. OBJECTIVE: To determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes. DESIGN, SETTING, AN …
IMPORTANCE: The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. OBJECTIVE: T …
Quality of Life and 1-Year Survival in Patients With Early Septic Shock: Long-Term Follow-Up of the Australasian Resuscitation in Sepsis Evaluation Trial.
Higgins AM, Peake SL, Bellomo R, Cooper DJ, Delaney A, Harris AH, Howe BD, Nichol AD, Webb SA, Williams PJ; Australasian Resuscitation in Sepsis Evaluation (ARISE) Investigators and the ANZICS Clinical Trials Group. Higgins AM, et al. Among authors: nichol ad. Crit Care Med. 2019 Jun;47(6):765-773. doi: 10.1097/CCM.0000000000003762. Crit Care Med. 2019. PMID: 30985391 Clinical Trial.
OBJECTIVES: To examine long-term survival and quality of life of patients with early septic shock. ...INTERVENTIONS: Early goal-directed therapy versus usual care. MEASUREMENTS AND MAIN RESULTS: Long-term survival was measured up to 12 months postrandomization. Heal …
OBJECTIVES: To examine long-term survival and quality of life of patients with early septic shock. ...INTERVENTIONS: Early goal-direc …
Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients With Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial.
Cooper DJ, Nichol AD, Bailey M, Bernard S, Cameron PA, Pili-Floury S, Forbes A, Gantner D, Higgins AM, Huet O, Kasza J, Murray L, Newby L, Presneill JJ, Rashford S, Rosenfeld JV, Stephenson M, Vallance S, Varma D, Webb SAR, Trapani T, McArthur C; POLAR Trial Investigators and the ANZICS Clinical Trials Group. Cooper DJ, et al. Among authors: nichol ad. JAMA. 2018 Dec 4;320(21):2211-2220. doi: 10.1001/jama.2018.17075. JAMA. 2018. PMID: 30357266 Free PMC article. Clinical Trial.
IMPORTANCE: After severe traumatic brain injury, induction of prophylactic hypothermia has been suggested to be neuroprotective and improve long-term neurologic outcomes. OBJECTIVE: To determine the effectiveness of early prophylactic hypothermia compared with normothermic …
IMPORTANCE: After severe traumatic brain injury, induction of prophylactic hypothermia has been suggested to be neuroprotective and improve …
The meaning of acute kidney injury and its relevance to intensive care and anaesthesia.
Moore EM, Bellomo R, Nichol AD. Moore EM, et al. Among authors: nichol ad. Anaesth Intensive Care. 2012 Nov;40(6):929-48. doi: 10.1177/0310057X1204000604. Anaesth Intensive Care. 2012. PMID: 23194202 Review.
Acute kidney injury (AKI) is the new consensus term for acute renal failure. The term describes a continuum of kidney injury, a common condition in the critically ill and after major surgery, which is associated with increased mortality. ...
Acute kidney injury (AKI) is the new consensus term for acute renal failure. The term describes a continuum of kidney injury, …
Measuring functional and quality of life outcomes following major head injury: common scales and checklists.
Nichol AD, Higgins AM, Gabbe BJ, Murray LJ, Cooper DJ, Cameron PA. Nichol AD, et al. Injury. 2011 Mar;42(3):281-7. doi: 10.1016/j.injury.2010.11.047. Epub 2010 Dec 8. Injury. 2011. PMID: 21145059 Review.
Traumatic brain injury (TBI) is a major public health issue, which results in significant mortality and long term disability. The profound impact of TBI is not only felt by the individuals who suffer the injury but also their care-givers and society as a whole. Clinicians …
Traumatic brain injury (TBI) is a major public health issue, which results in significant mortality and long term disability. The pro …
Can we improve neurological outcomes in severe traumatic brain injury? Something old (early prophylactic hypothermia) and something new (erythropoietin).
Nichol AD, Cooper DJ; POLAR Study Investigators on behalf of the ANZICS-Clinical Trials Group; EPO Study Investigators on behalf of the ANZICS-Clinical Trials Group. Nichol AD, et al. Injury. 2009 May;40(5):471-8. doi: 10.1016/j.injury.2009.01.002. Epub 2009 Apr 15. Injury. 2009. PMID: 19371869 Review.
Traumatic brain injury is a leading cause of mortality and long-term morbidity, particularly affecting young people. With our best therapies, one half of the patients with severe traumatic brain injury are never capable of living independently. ...
Traumatic brain injury is a leading cause of mortality and long-term morbidity, particularly affecting young people. With our best th …