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Does the first hour of continuous electroencephalography predict neonatal seizures?
Macdonald-Laurs E, Sharpe C, Nespeca M, Rismanchi N, Gold JJ, Kuperman R, Wang S, Lee NMD, Michelson DJ, Haas R, Reed P, Davis SL. Macdonald-Laurs E, et al. Among authors: nespeca m. Arch Dis Child Fetal Neonatal Ed. 2021 Mar;106(2):162-167. doi: 10.1136/archdischild-2020-318985. Epub 2020 Sep 14. Arch Dis Child Fetal Neonatal Ed. 2021. PMID: 32928896 Clinical Trial.
DESIGN AND SETTING: Retrospective multicentre diagnostic accuracy study. PATIENTS: 266 term neonates at risk of seizure or with suspected seizures. INTERVENTION: The first hour of cEEG was graded by expert and novice interpreters as normal, mildly, moderately or severely a …
DESIGN AND SETTING: Retrospective multicentre diagnostic accuracy study. PATIENTS: 266 term neonates at risk of seizure or with suspe …
Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial.
Sharpe C, Reiner GE, Davis SL, Nespeca M, Gold JJ, Rasmussen M, Kuperman R, Harbert MJ, Michelson D, Joe P, Wang S, Rismanchi N, Le NM, Mower A, Kim J, Battin MR, Lane B, Honold J, Knodel E, Arnell K, Bridge R, Lee L, Ernstrom K, Raman R, Haas RH; NEOLEV2 INVESTIGATORS. Sharpe C, et al. Among authors: nespeca m. Pediatrics. 2020 Jun;145(6):e20193182. doi: 10.1542/peds.2019-3182. Epub 2020 May 8. Pediatrics. 2020. PMID: 32385134 Free PMC article. Clinical Trial.
Higher-dose studies of levetiracetam are warranted, and definitive studies with long-term outcome measures are needed....
Higher-dose studies of levetiracetam are warranted, and definitive studies with long-term outcome measures are needed....
Assessing the Feasibility of Providing a Real-Time Response to Seizures Detected With Continuous Long-Term Neonatal Electroencephalography Monitoring.
Sharpe C, Davis SL, Reiner GE, Lee LI, Gold JJ, Nespeca M, Wang SG, Joe P, Kuperman R, Gardner M, Honold J, Lane B, Knodel E, Rowe D, Battin MR, Bridge R, Goodmar J, Castro B, Rasmussen M, Arnell K, Harbert M, Haas R. Sharpe C, et al. Among authors: nespeca m. J Clin Neurophysiol. 2019 Jan;36(1):9-13. doi: 10.1097/WNP.0000000000000525. J Clin Neurophysiol. 2019. PMID: 30289769 Free PMC article.
A randomized controlled trial of levodopa in patients with Angelman syndrome.
Tan WH, Bird LM, Sadhwani A, Barbieri-Welge RL, Skinner SA, Horowitz LT, Bacino CA, Noll LM, Fu C, Hundley RJ, Wink LK, Erickson CA, Barnes GN, Slavotinek A, Jeremy R, Rotenberg A, Kothare SV, Olson HE, Poduri A, Nespeca MP, Chu HC, Willen JM, Haas KF, Weeber EJ, Rufo PA. Tan WH, et al. Among authors: nespeca mp. Am J Med Genet A. 2018 May;176(5):1099-1107. doi: 10.1002/ajmg.a.38457. Epub 2017 Sep 25. Am J Med Genet A. 2018. PMID: 28944563 Free PMC article. Clinical Trial.
A mouse model of AS has reduced calcium/calmodulin-dependent kinase II activity due to excessive phosphorylation of specific threonine residues, leading to diminished long-term potentiation. In a rat model of Parkinson disease, levodopa reduced phosphorylation of various p …
A mouse model of AS has reduced calcium/calmodulin-dependent kinase II activity due to excessive phosphorylation of specific threonine resid …
Does Whole-Body Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy Affect Surfactant Disaturated-Phosphatidylcholine Kinetics?
Nespeca M, Giorgetti C, Nobile S, Ferrini I, Simonato M, Verlato G, Cogo P, Carnielli VP. Nespeca M, et al. PLoS One. 2016 Apr 12;11(4):e0153328. doi: 10.1371/journal.pone.0153328. eCollection 2016. PLoS One. 2016. PMID: 27070307 Free PMC article.
Both groups presented no clinically apparent lung disease. METHODS: Twenty-seven term or near term newborns requiring mechanical ventilation were studied (GA 38.62.2 wks). ...
Both groups presented no clinically apparent lung disease. METHODS: Twenty-seven term or near term newborns requiring mechanic …
Obesity and overweight as CAE comorbidities and differential drug response modifiers.
Arya R, Gillespie CW, Cnaan A, Devarajan M, Clark P, Shinnar S, Vinks AA, Mizuno K, Glauser TA; Childhood Absence Epilepsy Study Group. Arya R, et al. Neurology. 2016 Apr 26;86(17):1613-21. doi: 10.1212/WNL.0000000000002611. Epub 2016 Mar 30. Neurology. 2016. PMID: 27029636 Free PMC article. Clinical Trial.
OBJECTIVE: This study examined whether overweight and obesity are pretreatment comorbidities and predictors of short-term drug response in newly diagnosed untreated childhood absence epilepsy (CAE). ...
OBJECTIVE: This study examined whether overweight and obesity are pretreatment comorbidities and predictors of short-term drug respon …
Neurological Outcomes After Presumed Childhood Encephalitis.
Rismanchi N, Gold JJ, Sattar S, Glaser C, Sheriff H, Proudfoot J, Mower A, Nespeca M, Crawford JR, Wang SG. Rismanchi N, et al. Among authors: nespeca m. Pediatr Neurol. 2015 Sep;53(3):200-6. doi: 10.1016/j.pediatrneurol.2015.05.017. Epub 2015 Jun 11. Pediatr Neurol. 2015. PMID: 26220354
OBJECTIVE: To evaluate factors during acute presumed childhood encephalitis that are associated with development of long-term neurological sequelae. METHODS: A total of 217 patients from Rady Children's Hospital San Diego with suspected encephalitis who met criteria for th …
OBJECTIVE: To evaluate factors during acute presumed childhood encephalitis that are associated with development of long-term neurolo …
Surfactant protein B and A concentrations are increased in neonatal pneumonia.
D'Aronco S, Simonato M, Vedovelli L, Baritussio A, Verlato G, Nobile S, Giorgetti C, Nespeca M, Carnielli VP, Cogo PE. D'Aronco S, et al. Among authors: nespeca m. Pediatr Res. 2015 Oct;78(4):401-6. doi: 10.1038/pr.2015.123. Epub 2015 Jun 24. Pediatr Res. 2015. PMID: 26107393 Free PMC article.
BACKGROUND: Term newborns with pneumonia show a reduced pulmonary compliance due to multiple and ill-defined factors. ...The aim of this study was to clarify the meaning of SPs changes during pneumonia in term newborns. METHODS: In 28 term ventilated newborns …
BACKGROUND: Term newborns with pneumonia show a reduced pulmonary compliance due to multiple and ill-defined factors. ...The aim of t …
In vivo effect of pneumonia on surfactant disaturated-phosphatidylcholine kinetics in newborn infants.
Facco M, Nespeca M, Simonato M, Isak I, Verlato G, Ciambra G, Giorgetti C, Carnielli VP, Cogo PE. Facco M, et al. Among authors: nespeca m. PLoS One. 2014 Dec 31;9(12):e93612. doi: 10.1371/journal.pone.0093612. eCollection 2014. PLoS One. 2014. PMID: 25551219 Free PMC article.
We studied the kinetics of surfactant's major component, disaturated-phosphatidylcholine (DSPC), in neonatal pneumonia, and we compared our findings with those obtained from control newborn lungs. METHODS: We studied thirty-one term or near-term newborns (gestationa …
We studied the kinetics of surfactant's major component, disaturated-phosphatidylcholine (DSPC), in neonatal pneumonia, and we compared our …
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