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Mutations of GEMIN5 are associated with coenzyme Q(10) deficiency: long-term follow-up after treatment.
Cascajo-Almenara MV, Juliá-Palacios N, Urreizti R, Sánchez-Cuesta A, Fernández-Ayala DM, García-Díaz E, Oliva C, O Callaghan MDM, Paredes-Fuentes AJ, Moreno-Lozano PJ, Muchart J, Nascimento A, Ortez CI, Natera-de Benito D, Pineda M, Rivera N, Fortuna TR, Rajan DS, Navas P, Salviati L, Palau F, Yubero D, García-Cazorla A, Pandey UB, Santos-Ocaña C, Artuch R. Cascajo-Almenara MV, et al. Among authors: navas p. Eur J Hum Genet. 2024 Apr;32(4):426-434. doi: 10.1038/s41431-023-01526-2. Epub 2024 Feb 5. Eur J Hum Genet. 2024. PMID: 38316953
This association opens the possibility of oral CoQ(10) therapy, which is safe and has no observed side effects after long-term therapy....
This association opens the possibility of oral CoQ(10) therapy, which is safe and has no observed side effects after long-term therap …
Perspectives on ENCODE.
ENCODE Project Consortium; Snyder MP, Gingeras TR, Moore JE, Weng Z, Gerstein MB, Ren B, Hardison RC, Stamatoyannopoulos JA, Graveley BR, Feingold EA, Pazin MJ, Pagan M, Gilchrist DA, Hitz BC, Cherry JM, Bernstein BE, Mendenhall EM, Zerbino DR, Frankish A, Flicek P, Myers RM. ENCODE Project Consortium, et al. Nature. 2020 Jul;583(7818):693-698. doi: 10.1038/s41586-020-2449-8. Epub 2020 Jul 29. Nature. 2020. PMID: 32728248 Free PMC article.
The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. ...
The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functi …
Protective effect of maternal exercise against amyloid-β neurotoxicity in the male rat offspring's cerebellum.
Klein CP, Hoppe JB, Saccomori AB, Gindri Dos Santos B, August PM, Klein IP, Crestani MS, Bifi F, Hözer RM, Navas P, Salbego CG, Matté C. Klein CP, et al. Among authors: navas p. J Dev Orig Health Dis. 2020 Oct;11(5):521-532. doi: 10.1017/S2040174420000562. Epub 2020 Jun 23. J Dev Orig Health Dis. 2020. PMID: 32631472
In the present study, we assessed the potential of maternal exercise during pregnancy in long-term programming of young adult male rat offspring's cerebellar metabolism in conferring neuroprotection against amyloid-beta (Abeta) neurotoxicity. ...
In the present study, we assessed the potential of maternal exercise during pregnancy in long-term programming of young adult male ra …
Modulation of endogenous antioxidant activity by resveratrol and exercise in mouse liver is age dependent.
Tung BT, Rodríguez-Bies E, Ballesteros-Simarro M, Motilva V, Navas P, López-Lluch G. Tung BT, et al. Among authors: navas p. J Gerontol A Biol Sci Med Sci. 2014 Apr;69(4):398-409. doi: 10.1093/gerona/glt102. Epub 2013 Jul 16. J Gerontol A Biol Sci Med Sci. 2014. PMID: 23861386
Our results indicate that RSV and exercise revert the effect of aging in liver of old animals maintaining higher antioxidant activities and decreasing oxidative damage. Short-term interventions are enough to produce beneficial effects of RSV or exercise at later ages....
Our results indicate that RSV and exercise revert the effect of aging in liver of old animals maintaining higher antioxidant activities and …
Dicoumarol relieves serum withdrawal-induced G0/1 blockade in HL-60 cells through a superoxide-dependent mechanism.
Bello RI, Gómez-Díaz C, López-Lluch G, Forthoffer N, Córdoba-Pedregosa MC, Navas P, Villalba JM. Bello RI, et al. Among authors: navas p. Biochem Pharmacol. 2005 Jun 1;69(11):1613-25. doi: 10.1016/j.bcp.2005.03.012. Epub 2005 Apr 18. Biochem Pharmacol. 2005. PMID: 15896341
Inhibition of G0/1 blockade was confirmed by the increase of thymidine incorporation, the phosphorylation of retinoblastoma protein, and the promotion of cell growth in long-term treatments in the absence of serum. Dicoumarol treatment increased superoxide levels, but did …
Inhibition of G0/1 blockade was confirmed by the increase of thymidine incorporation, the phosphorylation of retinoblastoma protein, and the …
Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal.
Barroso MP, Gómez-Díaz C, Villalba JM, Burón MI, López-Lluch G, Navas P. Barroso MP, et al. Among authors: navas p. J Bioenerg Biomembr. 1997 Jun;29(3):259-67. doi: 10.1023/a:1022462111175. J Bioenerg Biomembr. 1997. PMID: 9298711
HL-60 cells were sensitive to serum removal, and an increase of lipid peroxidation and apoptosis was observed. Long-term treatment with ethidium bromide induced the mitochondria-deficient rho(o)HL-60 cell line. ...
HL-60 cells were sensitive to serum removal, and an increase of lipid peroxidation and apoptosis was observed. Long-term treatment wi …
Ascorbate stabilization is stimulated in rho(0)HL-60 cells by CoQ10 increase at the plasma membrane.
Gómez-Díaz C, Villalba JM, Pérez-Vicente R, Crane FL, Navas P. Gómez-Díaz C, et al. Among authors: navas p. Biochem Biophys Res Commun. 1997 May 8;234(1):79-81. doi: 10.1006/bbrc.1997.6582. Biochem Biophys Res Commun. 1997. PMID: 9168964
Long-term treatment with ethidium bromide of HL-60 cells induced a mitochondria-deficient rho degree cell line, where mitochondrial DNA can not be identified by PCR and cytochrome c oxidase activity was 80% decreased. ...
Long-term treatment with ethidium bromide of HL-60 cells induced a mitochondria-deficient rho degree cell line, where mitochondrial D …
Cyclic AMP-plus ATP-dependent modulation of the NADH oxidase activity of porcine liver plasma membranes.
Morré DJ, Navas P, Rodriguez-Aguilera JC, Morré DM, Villalba JM, de Cabo R, Lawrence J. Morré DJ, et al. Among authors: navas p. Biochim Biophys Acta. 1994 Dec 30;1224(3):566-74. doi: 10.1016/0167-4889(94)90295-x. Biochim Biophys Acta. 1994. PMID: 7803517
The oxidation was resistant to cyanide and responded to nanomolar concentrations of ATP alone or ATP in the presence of cyclic AMP. Both the Km for NADH and the long-term activity of the oxidase were affected. Upon incubation at 37 degrees C with cyclic AMP (0.1-10 nM) and …
The oxidation was resistant to cyanide and responded to nanomolar concentrations of ATP alone or ATP in the presence of cyclic AMP. Both the …
Iron chelators hydroxyurea and bathophenanthroline disulfonate inhibit DNA synthesis by different pathways.
Alcaín FJ, Löw H, Crane FL, Navas P. Alcaín FJ, et al. Among authors: navas p. Biochem Mol Biol Int. 1994 Sep;34(2):273-9. Biochem Mol Biol Int. 1994. PMID: 7849637
The permeable form 1,10 phenanthroline had the same inhibitory effect in short-term incubations that BPS. Moreover, 1,10 phenanthroline was cytotoxic in long-term incubations indicating that the site of BPS inhibition was outside the cell. Further, long-term …
The permeable form 1,10 phenanthroline had the same inhibitory effect in short-term incubations that BPS. Moreover, 1,10 phenanthroli …
16 results