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Hindbrain circuits in the control of eating behaviour and energy balance.
Cheng W, Gordian D, Ludwig MQ, Pers TH, Seeley RJ, Myers MG Jr. Cheng W, et al. Among authors: myers mg jr. Nat Metab. 2022 Jul;4(7):826-835. doi: 10.1038/s42255-022-00606-9. Epub 2022 Jul 25. Nat Metab. 2022. PMID: 35879458 Review.
Although the hypothalamus plays a crucial role in matching caloric intake with energy expenditure to achieve a stable body weight, it is now recognized that neuronal circuits in the hindbrain not only serve to produce nausea and to terminate feeding in response to food consumptio …
Although the hypothalamus plays a crucial role in matching caloric intake with energy expenditure to achieve a stable body weight, it is now …
NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity.
Cheng W, Ndoka E, Maung JN, Pan W, Rupp AC, Rhodes CJ, Olson DP, Myers MG Jr. Cheng W, et al. Among authors: myers mg jr. Nat Commun. 2021 Aug 30;12(1):5175. doi: 10.1038/s41467-021-25525-3. Nat Commun. 2021. PMID: 34462445 Free PMC article.
Calcitonin receptor (Calcr)-expressing neurons of the nucleus tractus solitarius (NTS; Calcr(NTS) cells) contribute to the long-term control of food intake and body weight. Here, we show that Prlh-expressing NTS (Prlh(NTS)) neurons represent a subset of Calcr(NTS) cells an …
Calcitonin receptor (Calcr)-expressing neurons of the nucleus tractus solitarius (NTS; Calcr(NTS) cells) contribute to the long-term …
Central nervous system regulation of organismal energy and glucose homeostasis.
Myers MG Jr, Affinati AH, Richardson N, Schwartz MW. Myers MG Jr, et al. Nat Metab. 2021 Jun;3(6):737-750. doi: 10.1038/s42255-021-00408-5. Epub 2021 Jun 21. Nat Metab. 2021. PMID: 34158655 Review.
Growing evidence implicates the brain in the regulation of both immediate fuel availability (for example, circulating glucose) and long-term energy stores (that is, adipose tissue mass). Rather than viewing the adipose tissue and glucose control systems separately, we sugg …
Growing evidence implicates the brain in the regulation of both immediate fuel availability (for example, circulating glucose) and long-t …
Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice.
Cheng W, Ndoka E, Hutch C, Roelofs K, MacKinnon A, Khoury B, Magrisso J, Kim KS, Rhodes CJ, Olson DP, Seeley RJ, Sandoval D, Myers MG Jr. Cheng W, et al. Among authors: myers mg jr. JCI Insight. 2020 Apr 9;5(7):e134359. doi: 10.1172/jci.insight.134359. JCI Insight. 2020. PMID: 32182221 Free PMC article.
We found that the cre-dependent ablation of NTS Ppgfl early in development or in adult mice failed to alter energy balance, suggesting the importance of pathways independent of NTS GLP1 for the long-term control of food intake. Consistently, while activating GLP1NTS cells …
We found that the cre-dependent ablation of NTS Ppgfl early in development or in adult mice failed to alter energy balance, suggesting the i …
Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding.
Cheng W, Gonzalez I, Pan W, Tsang AH, Adams J, Ndoka E, Gordian D, Khoury B, Roelofs K, Evers SS, MacKinnon A, Wu S, Frikke-Schmidt H, Flak JN, Trevaskis JL, Rhodes CJ, Fukada SI, Seeley RJ, Sandoval DA, Olson DP, Blouet C, Myers MG Jr. Cheng W, et al. Among authors: myers mg jr. Cell Metab. 2020 Feb 4;31(2):301-312.e5. doi: 10.1016/j.cmet.2019.12.012. Epub 2020 Jan 16. Cell Metab. 2020. PMID: 31955990 Free PMC article.
To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTS Calcr abrogated the long-term suppression of food intake, but not aversive responses, by CALCR agonists …
To understand hindbrain pathways involved in the control of food intake, we examined roles for calcitonin receptor (CALCR)-containing neuron …
Essential Role for Hypothalamic Calcitonin Receptor‒Expressing Neurons in the Control of Food Intake by Leptin.
Pan W, Adams JM, Allison MB, Patterson C, Flak JN, Jones J, Strohbehn G, Trevaskis J, Rhodes CJ, Olson DP, Myers MG Jr. Pan W, et al. Among authors: myers mg jr. Endocrinology. 2018 Apr 1;159(4):1860-1872. doi: 10.1210/en.2017-03259. Endocrinology. 2018. PMID: 29522093 Free PMC article.
The adipocyte-derived hormone leptin acts via its receptor (LepRb) on central nervous system neurons to communicate the repletion of long-term energy stores, to decrease food intake, and to promote energy expenditure. ...
The adipocyte-derived hormone leptin acts via its receptor (LepRb) on central nervous system neurons to communicate the repletion of long- …
Roles for Orexin/Hypocretin in the Control of Energy Balance and Metabolism.
Goforth PB, Myers MG. Goforth PB, et al. Among authors: myers mg. Curr Top Behav Neurosci. 2017;33:137-156. doi: 10.1007/7854_2016_51. Curr Top Behav Neurosci. 2017. PMID: 27909992 Review.
OX signaling not only promotes food-seeking behavior upon short-term fasting to increase food intake and defend body weight, but, conversely, OX signaling also supports energy expenditure to protect against obesity. ...
OX signaling not only promotes food-seeking behavior upon short-term fasting to increase food intake and defend body weight, but, con …
Minireview: CNS Mechanisms of Leptin Action.
Flak JN, Myers MG Jr. Flak JN, et al. Among authors: myers mg jr. Mol Endocrinol. 2016 Jan;30(1):3-12. doi: 10.1210/me.2015-1232. Epub 2015 Oct 20. Mol Endocrinol. 2016. PMID: 26484582 Free PMC article. Review.
Leptin is an adipocytokine that circulates in proportion to body fat to signal the repletion of long-term energy stores. Leptin acts via its receptor, LepRb, on specialized neuronal populations in the brain (mainly in the hypothalamus and brainstem) to alter motivation and …
Leptin is an adipocytokine that circulates in proportion to body fat to signal the repletion of long-term energy stores. Leptin acts …
E-cigarette use in the past and quitting behavior in the future: a population-based study.
Al-Delaimy WK, Myers MG, Leas EC, Strong DR, Hofstetter CR. Al-Delaimy WK, et al. Among authors: myers mg. Am J Public Health. 2015 Jun;105(6):1213-9. doi: 10.2105/AJPH.2014.302482. Epub 2015 Apr 16. Am J Public Health. 2015. PMID: 25880947 Free PMC article.
CONCLUSIONS: Smokers who have used e-cigarettes may be at increased risk for not being able to quit smoking. These findings, which need to be confirmed by longer-term cohort studies, have important policy and regulation implications regarding the use of e-cigarettes among …
CONCLUSIONS: Smokers who have used e-cigarettes may be at increased risk for not being able to quit smoking. These findings, which need to b …
Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance.
Flak JN, Patterson CM, Garfield AS, D'Agostino G, Goforth PB, Sutton AK, Malec PA, Wong JT, Germani M, Jones JC, Rajala M, Satin L, Rhodes CJ, Olson DP, Kennedy RT, Heisler LK, Myers MG Jr. Flak JN, et al. Among authors: myers mg jr. Nat Neurosci. 2014 Dec;17(12):1744-1750. doi: 10.1038/nn.3861. Epub 2014 Nov 10. Nat Neurosci. 2014. PMID: 25383904 Free PMC article.
During starvation, low leptin levels restrain energy utilization, enhancing long-term survival. To ensure short-term survival during hypoglycemia in fasted animals, the CRR must overcome this energy-sparing program and nutrient depletion. ...
During starvation, low leptin levels restrain energy utilization, enhancing long-term survival. To ensure short-term survival …
38 results