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Neurological Impairment in Critically Ill Patients on Dialysis: Research Letter for the INCOGNITO-AKI Feasibility Study.
Jawa NA, Silver SA, Holden RM, Scott SH, Day AG, Norman PA, Kwan BYM, Maslove DM, Muscedere J, Boyd JG. Jawa NA, et al. Among authors: muscedere j. Can J Kidney Health Dis. 2023 Aug 24;10:20543581231192743. doi: 10.1177/20543581231192743. eCollection 2023. Can J Kidney Health Dis. 2023. PMID: 37644980 Free PMC article.
OBJECTIVE: To assess the feasibility of testing the association between intradialytic rSO(2) and acute and long-term neurological outcomes. DESIGN: Longitudinal observational study. ...We measured acute neurological impairment by daily delirium screening and long-term …
OBJECTIVE: To assess the feasibility of testing the association between intradialytic rSO(2) and acute and long-term neurological out …
Development and validation of a hospital frailty risk measure using Canadian clinical administrative data.
Amuah JE, Molodianovitsh K, Carbone S, Diestelkamp N, Guo Y, Hogan DB, Li M, Maxwell CJ, Muscedere J, Rockwood K, Sinha S, Theou O, Karmakar-Hore S. Amuah JE, et al. Among authors: muscedere j. CMAJ. 2023 Mar 27;195(12):E437-E448. doi: 10.1503/cmaj.220926. CMAJ. 2023. PMID: 36972914 Free PMC article.
For the continuous risk score format (unit = 0.1), the hazard ratio (HR) for 1-year risk of death was 1.39 (95% confidence interval [CI] 1.38-1.41), with a C-statistic of 0.717 (95% CI 0.715-0.720); the odds ratio for high users of hospital beds was 1.85 (95% CI 1.82-1.88), with …
For the continuous risk score format (unit = 0.1), the hazard ratio (HR) for 1-year risk of death was 1.39 (95% confidence interval [CI] 1.3 …
Identifying neurocognitive outcomes and cerebral oxygenation in critically ill adults on acute kidney replacement therapy in the intensive care unit: the INCOGNITO-AKI study protocol.
Jawa NA, Holden RM, Silver SA, Scott SH, Day AG, Norman PA, Kwan BYM, Maslove DM, Muscedere J, Boyd JG. Jawa NA, et al. Among authors: muscedere j. BMJ Open. 2021 Aug 17;11(8):e049250. doi: 10.1136/bmjopen-2021-049250. BMJ Open. 2021. PMID: 34404711 Free PMC article.
Adults on dialysis in the ICU may be particularly at risk of neurocognitive impairment, as survivors of critical illness are already predisposed to developing cerebrovascular disease and cognitive dysfunction long-term relative to healthy controls. Regional cerebral oxygen …
Adults on dialysis in the ICU may be particularly at risk of neurocognitive impairment, as survivors of critical illness are already predisp …
Association between supportive interventions and healthcare utilization and outcomes in patients on long-term prescribed opioid therapy presenting to acute healthcare settings: a systematic review and meta-analysis.
Deschamps J, Gilbertson J, Straube S, Dong K, MacMaster FP, Korownyk C, Montgomery L, Mahaffey R, Downar J, Clarke H, Muscedere J, Rittenbach K, Featherstone R, Sebastianski M, Vandermeer B, Lynam D, Magnussen R, Bagshaw SM, Rewa OG. Deschamps J, et al. Among authors: muscedere j. BMC Emerg Med. 2021 Jan 29;21(1):17. doi: 10.1186/s12873-020-00398-9. BMC Emerg Med. 2021. PMID: 33514325 Free PMC article.
BACKGROUND: Long-term prescription of opioids by healthcare professionals has been linked to poor individual patient outcomes and high resource utilization. ...CONCLUSION: For patients presenting to acute healthcare settings with complications related to long-term o …
BACKGROUND: Long-term prescription of opioids by healthcare professionals has been linked to poor individual patient outcomes and hig …
Delirium, Cerebral Perfusion, and High-Frequency Vital-Sign Monitoring in the Critically Ill. The CONFOCAL-2 Feasibility Study.
Khan JM, Wood MD, Lee KFH, Maslove D, Muscedere J, English SW, Ball I, Slessarev M, Boyd JG. Khan JM, et al. Among authors: muscedere j. Ann Am Thorac Soc. 2021 Jan;18(1):112-121. doi: 10.1513/AnnalsATS.202002-093OC. Ann Am Thorac Soc. 2021. PMID: 32780600
The full study will aim to assess the association between noninvasively derived surrogate markers of cerebral perfusion, delirium development, and long-term cognitive outcomes in critically ill patients.Methods: Adult patients in the ICU were enrolled if they had shock and …
The full study will aim to assess the association between noninvasively derived surrogate markers of cerebral perfusion, delirium developmen …
A pilot randomized controlled trial of 7 versus 14 days of antibiotic treatment for bloodstream infection on non-intensive care versus intensive care wards.
Daneman N, Rishu AH, Pinto R, Arabi Y, Belley-Cote EP, Cirone R, Downing M, Cook DJ, Hall R, McGuinness S, McIntyre L, Muscedere J, Parke R, Reynolds S, Rogers BA, Shehabi Y, Shin P, Whitlock R, Fowler RA; Canadian Critical Care Trials Group. Daneman N, et al. Among authors: muscedere j. Trials. 2020 Jan 15;21(1):92. doi: 10.1186/s13063-019-4033-9. Trials. 2020. PMID: 31941546 Free PMC article. Clinical Trial.
Frailty and associated outcomes and resource utilization following in-hospital cardiac arrest.
Fernando SM, McIsaac DI, Rochwerg B, Cook DJ, Bagshaw SM, Muscedere J, Munshi L, Nolan JP, Perry JJ, Downar J, Dave C, Reardon PM, Tanuseputro P, Kyeremanteng K. Fernando SM, et al. Among authors: muscedere j. Resuscitation. 2020 Jan 1;146:138-144. doi: 10.1016/j.resuscitation.2019.11.011. Epub 2019 Nov 27. Resuscitation. 2020. PMID: 31785373
Secondary outcomes include return of spontaneous circulation (ROSC), discharge to long-term care, and hospital costs. We used multivariable logistic regression to adjust for known confounders. ...CONCLUSIONS: Frail individuals who experience an IHCA are more likely to die …
Secondary outcomes include return of spontaneous circulation (ROSC), discharge to long-term care, and hospital costs. We used multiva …
Frailty and invasive mechanical ventilation: association with outcomes, extubation failure, and tracheostomy.
Fernando SM, McIsaac DI, Rochwerg B, Bagshaw SM, Muscedere J, Munshi L, Ferguson ND, Seely AJE, Cook DJ, Dave C, Tanuseputro P, Kyeremanteng K. Fernando SM, et al. Among authors: muscedere j. Intensive Care Med. 2019 Dec;45(12):1742-1752. doi: 10.1007/s00134-019-05795-8. Epub 2019 Oct 8. Intensive Care Med. 2019. PMID: 31595352
The primary outcome was hospital mortality. Secondary outcomes included discharge to long-term care, extubation failure at time of first liberation attempt, and tracheostomy. ...CONCLUSIONS: The presence of frailty among patients receiving mechanical ventilation is associa …
The primary outcome was hospital mortality. Secondary outcomes included discharge to long-term care, extubation failure at time of fi …
Frailty and Aging: How the Danish Experience Might Inform Canada.
Muscedere J, Barrie C, Chan K, Cooper B, Critchley K, Kim P, Lorbergs A, Mackenzie I, Martineau C, Noseworthy T, O'Neil M, Resin J, Sinha S, Williams R. Muscedere J, et al. Healthc Q. 2019 Apr;22(1):14-21. doi: 10.12927/hcq.2019.25841. Healthc Q. 2019. PMID: 31244463
Assessing the relationship between near-infrared spectroscopy-derived regional cerebral oxygenation and neurological dysfunction in critically ill adults: a prospective observational multicentre protocol, on behalf of the Canadian Critical Care Trials Group.
Wood MD, Khan J, Lee KFH, Maslove DM, Muscedere J, Hunt M, Scott SH, Day A, Jacobson JA, Ball I, Slessarev M, O'Regan N, English SW, McCredie V, Chasse M, Griesdale D, Boyd JG. Wood MD, et al. Among authors: muscedere j. BMJ Open. 2019 Jun 25;9(6):e029189. doi: 10.1136/bmjopen-2019-029189. BMJ Open. 2019. PMID: 31243036 Free PMC article.
This study will use near-infrared spectroscopy to non-invasively quantify regional cerebral oxygenation (rSO(2)) to assess the association between poor rSO(2) during the first 72 hours of critical illness with delirium severity, as well as long-term sensorimotor and cognit …
This study will use near-infrared spectroscopy to non-invasively quantify regional cerebral oxygenation (rSO(2)) to assess the association b …
15 results