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Influence of substance use on male reproductive health and offspring outcomes.
Lo JO, Hedges JC, Chou WH, Tager KR, Bachli ID, Hagen OL, Murphy SK, Hanna CB, Easley CA 4th. Lo JO, et al. Among authors: murphy sk. Nat Rev Urol. 2024 Apr 25. doi: 10.1038/s41585-024-00868-w. Online ahead of print. Nat Rev Urol. 2024. PMID: 38664544 Review.
Substance use might be contributing to the ongoing global decline in male fertility, and emerging evidence has linked paternal substance use with short-term and long-term adverse effects on offspring development and outcomes. ...
Substance use might be contributing to the ongoing global decline in male fertility, and emerging evidence has linked paternal substance use …
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence.
Choudhary P, Monasso GS, Karhunen V, Ronkainen J, Mancano G, Howe CG, Niu Z, Zeng X, Guan W, Dou J, Feinberg JI, Mordaunt C, Pesce G, Baïz N, Alfano R, Martens DS, Wang C, Isaevska E, Keikkala E, Mustaniemi S, Thio CHL, Fraszczyk E, Tobi EW, Starling AP, Cosin-Tomas M, Urquiza J, Röder S, Hoang TT, Page C, Jima DD, House JS, Maguire RL, Ott R, Pawlow X, Sirignano L, Zillich L, Malmberg A, Rauschert S, Melton P, Gong T, Karlsson R, Fore R, Perng W, Laubach ZM, Czamara D, Sharp G, Breton CV, Schisterman E, Yeung E, Mumford SL, Fallin MD, LaSalle JM, Schmidt RJ, Bakulski KM, Annesi-Maesano I, Heude B, Nawrot TS, Plusquin M, Ghantous A, Herceg Z, Nisticò L, Vafeiadi M, Kogevinas M, Vääräsmäki M, Kajantie E, Snieder H, Corpeleijn E, Steegers-Theunissen RPM, Yang IV, Dabelea D, Fossati S, Zenclussen AC, Herberth G, Magnus M, Håberg SE, London SJ, Munthe-Kaas MC, Murphy SK, Hoyo C, Ziegler AG, Hummel S, Witt SH, Streit F, Frank J, Räikkönen K, Lahti J, Huang RC, Almqvist C, Hivert MF, Jaddoe VWV, Järvelin MR, Kantomaa M, Felix JF, Sebert S. Choudhary P, et al. Among authors: murphy sk. Mol Psychiatry. 2023 Dec 5. doi: 10.1038/s41380-023-02331-5. Online ahead of print. Mol Psychiatry. 2023. PMID: 38052982
Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. ...MEA was found to be associated with …
Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associ …
AHRR Hypomethylation mediates the association between maternal smoking and metabolic profiles in children.
Vidal AC, Chandramouli SA, Marchesoni J, Brown N, Liu Y, Murphy SK, Maguire R, Wang Y, Abdelmalek MF, Mavis AM, Bashir MR, Jima D, Skaar DA, Hoyo C, Moylan CA. Vidal AC, et al. Among authors: murphy sk. Hepatol Commun. 2023 Sep 27;7(10):e0243. doi: 10.1097/HC9.0000000000000243. eCollection 2023 Oct 1. Hepatol Commun. 2023. PMID: 37755881 Free PMC article.
RESULTS: Average AHRR methylation at birth was significantly higher among children of nonsmoking mothers compared with children of mothers who smoked (69.8% 4.4% vs. 63.5% 5.5, p=0.0006). ...Further studies are needed to replicate these findings and to explore their causal …
RESULTS: Average AHRR methylation at birth was significantly higher among children of nonsmoking mothers compared with children of mo …
Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes.
Shorey-Kendrick LE, Roberts VHJ, D'Mello RJ, Sullivan EL, Murphy SK, Mccarty OJT, Schust DJ, Hedges JC, Mitchell AJ, Terrobias JJD, Easley CA 4th, Spindel ER, Lo JO. Shorey-Kendrick LE, et al. Among authors: murphy sk. Clin Epigenetics. 2023 Jul 6;15(1):104. doi: 10.1186/s13148-023-01519-4. Clin Epigenetics. 2023. PMID: 37415206 Free PMC article.
CONCLUSIONS: Overall, our findings reveal that prenatal THC exposure alters placental and fetal DNA methylation at genes involved in neurobehavioral development that may influence longer-term offspring outcomes. The data from this study add to the limited existing literatu …
CONCLUSIONS: Overall, our findings reveal that prenatal THC exposure alters placental and fetal DNA methylation at genes involved in neurobe …
An epigenetic synopsis of parental substance use.
Lo JO, D'Mello RJ, Watch L, Schust DJ, Murphy SK. Lo JO, et al. Among authors: murphy sk. Epigenomics. 2023 Apr;15(7):453-473. doi: 10.2217/epi-2023-0064. Epub 2023 Jun 7. Epigenomics. 2023. PMID: 37282544 Free PMC article. Review.
This review examines the contributions and influence of parental substance use on the gametes and potential transmissibility to the offspring's epigenome as possible areas to target public health warnings and healthcare provider counseling of individuals or couples in the pre-con …
This review examines the contributions and influence of parental substance use on the gametes and potential transmissibility to the offsprin …
Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits.
Crute CE, Landon CD, Garner A, Hall SM, Everitt JI, Zhang S, Blake B, Olofsson D, Chen H, Stapleton HM, Murphy SK, Feng L. Crute CE, et al. Among authors: murphy sk. Toxicol Sci. 2023 Feb 17;191(2):239-252. doi: 10.1093/toxsci/kfac126. Toxicol Sci. 2023. PMID: 36453863 Free PMC article.
Statistical analysis of placental weight via a mixed model statistical approach identified a significant interaction term between PFBS high dose and fetal sex, suggesting a sex-specific effect on placental weight. ...
Statistical analysis of placental weight via a mixed model statistical approach identified a significant interaction term between PFB …
Epigenetic Regulation of Claudin-1 in the Development of Ovarian Cancer Recurrence and Drug Resistance.
Visco ZR, Sfakianos G, Grenier C, Boudreau MH, Simpson S, Rodriguez I, Whitaker R, Yao DY, Berchuck A, Murphy SK, Huang Z. Visco ZR, et al. Among authors: murphy sk. Front Oncol. 2021 Mar 22;11:620873. doi: 10.3389/fonc.2021.620873. eCollection 2021. Front Oncol. 2021. PMID: 33828978 Free PMC article.
An independent dataset showed that this correlation is stronger in tumors from short-term (<3y) survivors than in tumors from long-term (>7y) survivors (R= -0.41 to -0.46 versus R= 0.06 to -0.19, respectively). The presence of this inverse correlation in short …
An independent dataset showed that this correlation is stronger in tumors from short-term (<3y) survivors than in tumors from long …
Epigenetic alterations in cytochrome P450 oxidoreductase (Por) in sperm of rats exposed to tetrahydrocannabinol (THC).
Acharya KS, Schrott R, Grenier C, Huang Z, Holloway Z, Hawkey A, Levin ED, Murphy SK. Acharya KS, et al. Among authors: murphy sk. Sci Rep. 2020 Jul 23;10(1):12251. doi: 10.1038/s41598-020-69204-7. Sci Rep. 2020. PMID: 32704063 Free PMC article.
As marijuana legalization is increasing, research regarding possible long-term risks for users and their offspring is needed. Little data exists on effects of paternal tetrahydrocannabinol (THC) exposure prior to reproduction. ...
As marijuana legalization is increasing, research regarding possible long-term risks for users and their offspring is needed. Little …
Cannabis use and the sperm epigenome: a budding concern?
Schrott R, Murphy SK. Schrott R, et al. Among authors: murphy sk. Environ Epigenet. 2020 Mar 19;6(1):dvaa002. doi: 10.1093/eep/dvaa002. eCollection 2020 Jan. Environ Epigenet. 2020. PMID: 32211199 Free PMC article. Review.
Currently considered the most commonly used illicit psychoactive drug, recreational cannabis is legal in 11 states and Washington, DC, and male use is an important and understudied concern. Questions remain, however, about the potential long-term consequences of this expos …
Currently considered the most commonly used illicit psychoactive drug, recreational cannabis is legal in 11 states and Washington, DC, and m …
Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring.
Levin ED, Hawkey AB, Hall BJ, Cauley M, Slade S, Yazdani E, Kenou B, White H, Wells C, Rezvani AH, Murphy SK. Levin ED, et al. Among authors: murphy sk. Neurotoxicol Teratol. 2019 Jul-Aug;74:106806. doi: 10.1016/j.ntt.2019.04.003. Epub 2019 Apr 24. Neurotoxicol Teratol. 2019. PMID: 31028824
This study shows that premating paternal THC exposure even at a modest dose for a brief period can cause deleterious long-term behavioral effects in the offspring, notably significant impairment in an operant attention task. Further research should be conducted to determin …
This study shows that premating paternal THC exposure even at a modest dose for a brief period can cause deleterious long-term behavi …
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