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CAR T therapy from haematological malignancies to aging-related diseases: An ever-expanding universe.
Ramoni D, Montecucco F, Carbone F. Ramoni D, et al. Among authors: montecucco f. Eur J Clin Invest. 2024 Mar 29:e14203. doi: 10.1111/eci.14203. Online ahead of print. Eur J Clin Invest. 2024. PMID: 38551245 Review.
METHODS: This narrative review discusses how CAR T therapy still faces challenges in overcoming the complexity of the solid tumour microenvironment and the concerns that its long-term activity raises about potential unknown and unpredictable consequences in non-oncological …
METHODS: This narrative review discusses how CAR T therapy still faces challenges in overcoming the complexity of the solid tumour microenvi …
Circulating Osteopontin Predicts Clinical and Radiological Response in First-Line Treatment of Advanced Non-Small Cell Lung Cancer.
Ramoni D, Coco S, Rossi G, Dellepiane C, Bennicelli E, Santamaria S, Zinoli L, Tagliafico AS, Tagliamento M, Barletta G, Liberale L, Tirandi A, Minetti S, Bertolotto M, Montecucco F, Genova C, Carbone F. Ramoni D, et al. Among authors: montecucco f. Lung. 2024 Apr;202(2):197-210. doi: 10.1007/s00408-024-00675-5. Epub 2024 Mar 13. Lung. 2024. PMID: 38480620 Free PMC article.
CONCLUSION: Baseline levels of serum OPN is closely associated with performance status and short/long term outcomes in patients with advanced NSCLC, which are candidate to pembrolizumab-based regimens. ...
CONCLUSION: Baseline levels of serum OPN is closely associated with performance status and short/long term outcomes in patients with …
Facing ethical concerns in the age of precise gene therapy: Outlook on inherited arrhythmias.
Carbone F, Montecucco F. Carbone F, et al. Among authors: montecucco f. World J Cardiol. 2024 Feb 26;16(2):64-66. doi: 10.4330/wjc.v16.i2.64. World J Cardiol. 2024. PMID: 38456071 Free PMC article.
A growing body of studies are reporting uncertainty in payback periods with intuitive short-term effects for insurance-based healthcare systems, but potential concerns for universal healthcare systems in the long term as well. ...
A growing body of studies are reporting uncertainty in payback periods with intuitive short-term effects for insurance-based healthca …
Statins, ACE/ARBs drug use, and risk of pneumonia in hospitalized older patients: a retrospective cohort study.
Franchi C, Rossio R, Mandelli S, Ardoino I, Nobili A, Peyvandi F, Mannucci PM; REPOSI Investigators. Franchi C, et al. Intern Emerg Med. 2024 Apr;19(3):689-696. doi: 10.1007/s11739-023-03528-w. Epub 2024 Feb 14. Intern Emerg Med. 2024. PMID: 38353881
The aims of this study is to evaluate the association between angiotensin-converting enzyme inhibitor (ACE-I), angiotensin II receptor blocker (ARBs) and/or statin use with the risk of pneumonia, as well as and with in-hospital and short-term outpatient mortality in hospit …
The aims of this study is to evaluate the association between angiotensin-converting enzyme inhibitor (ACE-I), angiotensin II receptor block …
Early sclerostin assessment in frail elderly patients with sepsis: insights on short- and long-term mortality prediction.
Tirandi A, Arboscello E, Ministrini S, Liberale L, Bonaventura A, Vecchié A, Bertolotto M, Giacobbe DR, Castellani L, Mirabella M, Minetti S, Bassetti M, Montecucco F, Carbone F. Tirandi A, et al. Among authors: montecucco f. Intern Emerg Med. 2023 Aug;18(5):1509-1519. doi: 10.1007/s11739-023-03223-w. Epub 2023 Mar 21. Intern Emerg Med. 2023. PMID: 36943596 Free PMC article.
Thirty-day mortality was set as primary outcome. In-hospital and long-term mortality (2.5 years of median follow-up) were assessed as secondary outcomes. ...The degree of this variation further predicted long-term mortality (HR for delta SOST T0-day 14: 1.006 with 9 …
Thirty-day mortality was set as primary outcome. In-hospital and long-term mortality (2.5 years of median follow-up) were assessed as …
Secondary prevention after intracerebral haemorrhage.
Toffali M, Carbone F, Fainardi E, Morotti A, Montecucco F, Liberale L, Padovani A. Toffali M, et al. Among authors: montecucco f. Eur J Clin Invest. 2023 Jun;53(6):e13962. doi: 10.1111/eci.13962. Epub 2023 Feb 8. Eur J Clin Invest. 2023. PMID: 36721900 Review.
BACKGROUND: Intracerebral haemorrhage (ICH) has high mortality in the acute phase and poor functional outcome in the majority of survivors. ICH recurrence is a major determinant of long-term prognosis and is the most feared complication of antithrombotic treatment. ...Ongo …
BACKGROUND: Intracerebral haemorrhage (ICH) has high mortality in the acute phase and poor functional outcome in the majority of survivors. …
Markers of neutrophil mediated inflammation associate with disturbed continuous electroencephalogram after out of hospital cardiac arrest.
Pekkarinen PT, Carbone F, Minetti S, Ramoni D, Ristagno G, Latini R, Wihersaari L, Blennow K, Zetterberg H, Toppila J, Jakkula P, Reinikainen M, Montecucco F, Skrifvars MB. Pekkarinen PT, et al. Among authors: montecucco f. Acta Anaesthesiol Scand. 2023 Jan;67(1):94-103. doi: 10.1111/aas.14145. Epub 2022 Sep 12. Acta Anaesthesiol Scand. 2023. PMID: 36053856 Free PMC article.
We defined 6-month cerebral performance category (CPC) 1-2 as good and CPC 3-5 as poor long-term neurological outcome. We compared the prognostic value of biomarkers for 6-month neurological outcome to neurofilament light (NFL) measured at 48 h. ...However, the studied inf …
We defined 6-month cerebral performance category (CPC) 1-2 as good and CPC 3-5 as poor long-term neurological outcome. We compared th …
Imaging techniques for the assessment of adverse cardiac remodeling in metabolic syndrome.
Preda A, Liberale L, Montecucco F. Preda A, et al. Among authors: montecucco f. Heart Fail Rev. 2022 Sep;27(5):1883-1897. doi: 10.1007/s10741-021-10195-6. Epub 2021 Nov 18. Heart Fail Rev. 2022. PMID: 34796433 Review.
In this review, we summarize the pathophysiology of MetS-related cardiac remodeling and illustrate the relevance of state-of-the-art multimodality cardiac imaging to identify and quantify the degree of myocardial involvement, prognosticate long-term clinical outcome, and p …
In this review, we summarize the pathophysiology of MetS-related cardiac remodeling and illustrate the relevance of state-of-the-art multimo …
TNF-α antagonism rescues the effect of ageing on stroke: Perspectives for targeting inflamm-ageing.
Liberale L, Bonetti NR, Puspitasari YM, Vukolic A, Akhmedov A, Diaz-Cañestro C, Keller S, Montecucco F, Merlini M, Semerano A, Giacalone G, Bacigaluppi M, Sessa M, Ruschitzka F, Lüscher TF, Libby P, Beer JH, Camici GG. Liberale L, et al. Among authors: montecucco f. Eur J Clin Invest. 2021 Nov;51(11):e13600. doi: 10.1111/eci.13600. Epub 2021 Jun 2. Eur J Clin Invest. 2021. PMID: 34076259 Free PMC article.
Patients with ischemic stroke showed increased TNF-alpha plasma levels which correlated with worsened short-term neurological outcome as well as with age. CONCLUSIONS: This study identifies TNF-alpha as a causative contributor to the deleterious effect of aging on stroke a …
Patients with ischemic stroke showed increased TNF-alpha plasma levels which correlated with worsened short-term neurological outcome …
Long-term dietary supplementation with plant-derived omega-3 fatty acid improves outcome in experimental ischemic stroke.
Bonetti NR, Liberale L, Akhmedov A, Pasterk L, Gobbato S, Puspitasari YM, Vukolic A, Saeedi Saravi SS, Coester B, Horvath C, Osto E, Montecucco F, Lüscher TF, Beer JH, Camici GG. Bonetti NR, et al. Among authors: montecucco f. Atherosclerosis. 2021 May;325:89-98. doi: 10.1016/j.atherosclerosis.2021.04.005. Epub 2021 Apr 20. Atherosclerosis. 2021. PMID: 33915355 Free article.
We hereby aimed to investigate the impact of a clinically relevant long-term dietary intervention with ALA on stroke outcome. METHODS: Six month-old C57BL/6 wildtype males were either fed an ALA-rich (high ALA) or a control diet (low ALA) for 12 months. ...
We hereby aimed to investigate the impact of a clinically relevant long-term dietary intervention with ALA on stroke outcome. METHODS …
28 results