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p16 a biomarker of aging and tolerance for cancer therapy.
Muss HB, Smitherman A, Wood WA, Nyrop K, Tuchman S, Randhawa PK, Entwistle AR, Mitin N, Shachar SS. Muss HB, et al. Among authors: mitin n. Transl Cancer Res. 2020 Sep;9(9):5732-5742. doi: 10.21037/tcr.2020.03.39. Transl Cancer Res. 2020. PMID: 35117935 Free PMC article. Review.
A biomarker that would reflect biologic age and any and all health deficits in a cancer patient at a distinct point in time might help predict long term outcomes related to treatment, especially toxicity and overall survival. p16(INK4a) (hereafter referred to as p16) expre …
A biomarker that would reflect biologic age and any and all health deficits in a cancer patient at a distinct point in time might help predi …
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. Demaria M, et al. Among authors: mitin n. Cancer Discov. 2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15. Cancer Discov. 2017. PMID: 27979832 Free PMC article.
Using a transgenic mouse that permits tracking and eliminating senescent cells, we show that therapy-induced senescent (TIS) cells persist and contribute to local and systemic inflammation. Eliminating TIS cells reduced several short- and long-term effects of the drugs, in …
Using a transgenic mouse that permits tracking and eliminating senescent cells, we show that therapy-induced senescent (TIS) cells persist a …