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The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity.
Torres CM, Biran A, Burney MJ, Patel H, Henser-Brownhill T, Cohen AS, Li Y, Ben-Hamo R, Nye E, Spencer-Dene B, Chakravarty P, Efroni S, Matthews N, Misteli T, Meshorer E, Scaffidi P. Torres CM, et al. Among authors: misteli t. Science. 2016 Sep 30;353(6307):aaf1644. doi: 10.1126/science.aaf1644. Science. 2016. PMID: 27708074 Free PMC article.
Here, we show that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. Numerous cancer types exhibit high inter- and intratumor heterogeneity of H1.0, with H1.0 levels correlating with t …
Here, we show that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long- …
Transcription dynamics.
Hager GL, McNally JG, Misteli T. Hager GL, et al. Among authors: misteli t. Mol Cell. 2009 Sep 24;35(6):741-53. doi: 10.1016/j.molcel.2009.09.005. Mol Cell. 2009. PMID: 19782025 Free PMC article. Review.
The basal transcription machinery and regulatory components are dynamically recruited to their target genes, and dynamic interactions of transcription factors with chromatin--and with each other--play a key role in RNA polymerase assembly, initiation, and elongation. These short- …
The basal transcription machinery and regulatory components are dynamically recruited to their target genes, and dynamic interactions of tra …