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SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R. Mercken EM, et al. Among authors: minor rk. Aging Cell. 2014 Oct;13(5):787-96. doi: 10.1111/acel.12220. Epub 2014 Jun 16. Aging Cell. 2014. PMID: 24931715 Free PMC article.
This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensitivity associated with higher mitochondrial content and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle …
This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density, and insulin sensiti …
Metformin improves healthspan and lifespan in mice.
Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R. Martin-Montalvo A, et al. Among authors: minor rk. Nat Commun. 2013;4:2192. doi: 10.1038/ncomms3192. Nat Commun. 2013. PMID: 23900241 Free PMC article.
Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age extends healthspan and lifespan in male mice, while a higher dose (1% w/w) was toxic. ...
Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we show that long-term treatment with metformin …
SRT1720 improves survival and healthspan of obese mice.
Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R. Minor RK, et al. Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18. Sci Rep. 2011. PMID: 22355589 Free PMC article.
Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC-1alpha-dependent manner. These findings indicate that SRT1720 has long-term benefits and demonstrate for the first time the feasibili …
Using a conditional SIRT1 knockout mouse and specific gene knockdowns we show SRT1720 affects mitochondrial respiration in a Sirt1- and PGC- …
Dietary interventions to extend life span and health span based on calorie restriction.
Minor RK, Allard JS, Younts CM, Ward TM, de Cabo R. Minor RK, et al. J Gerontol A Biol Sci Med Sci. 2010 Jul;65(7):695-703. doi: 10.1093/gerona/glq042. Epub 2010 Apr 6. J Gerontol A Biol Sci Med Sci. 2010. PMID: 20371545 Free PMC article. Review.
The societal impact of obesity, diabetes, and other metabolic disorders continues to rise despite increasing evidence of their negative long-term consequences on health span, longevity, and aging. Unfortunately, dietary management and exercise frequently fail as remedies, …
The societal impact of obesity, diabetes, and other metabolic disorders continues to rise despite increasing evidence of their negative long …
Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats.
Minor RK, Smith DL Jr, Sossong AM, Kaushik S, Poosala S, Spangler EL, Roth GS, Lane M, Allison DB, de Cabo R, Ingram DK, Mattison JA. Minor RK, et al. Toxicol Appl Pharmacol. 2010 Mar 15;243(3):332-9. doi: 10.1016/j.taap.2009.11.025. Epub 2009 Dec 22. Toxicol Appl Pharmacol. 2010. PMID: 20026095 Free PMC article.
Compounds like 2-deoxy-D-glucose (2DG) that can recapitulate the metabolic effects of CR are of great interest for their potential to extend lifespan. 2DG treatment has been shown to have potential therapeutic benefits for treating cancer and seizures. 2DG has also recapitulated …
Compounds like 2-deoxy-D-glucose (2DG) that can recapitulate the metabolic effects of CR are of great interest for their potential to extend …