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Life-long consumption of high level of fruits and vegetables reduces tumor incidence and extends median lifespan in mice.
Guo W, Ortega EF, Wu D, Li L, Bronson RT, Boehm SK, Meydani SN. Guo W, et al. Among authors: meydani sn. Front Nutr. 2023 Dec 6;10:1286792. doi: 10.3389/fnut.2023.1286792. eCollection 2023. Front Nutr. 2023. PMID: 38125727 Free PMC article.
No significant difference in tumor incidence between the LF-C and LF + FV groups was observed. Long-term FV supplementation reduced systemic inflammation and blood lipids. ...
No significant difference in tumor incidence between the LF-C and LF + FV groups was observed. Long-term FV supplementation reduced s …
Age-associated alterations in immune function and inflammation.
Lewis ED, Wu D, Meydani SN. Lewis ED, et al. Among authors: meydani sn. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Aug 30;118:110576. doi: 10.1016/j.pnpbp.2022.110576. Epub 2022 May 17. Prog Neuropsychopharmacol Biol Psychiatry. 2022. PMID: 35588939 Review.
Immunosenescence is a term used to describe the age-related changes in the immune system. ...
Immunosenescence is a term used to describe the age-related changes in the immune system. ...
Substituting whole grains for refined grains in a 6-wk randomized trial has a modest effect on gut microbiota and immune and inflammatory markers of healthy adults.
Vanegas SM, Meydani M, Barnett JB, Goldin B, Kane A, Rasmussen H, Brown C, Vangay P, Knights D, Jonnalagadda S, Koecher K, Karl JP, Thomas M, Dolnikowski G, Li L, Saltzman E, Wu D, Meydani SN. Vanegas SM, et al. Among authors: meydani sn. Am J Clin Nutr. 2017 Mar;105(3):635-650. doi: 10.3945/ajcn.116.146928. Epub 2017 Feb 8. Am J Clin Nutr. 2017. PMID: 28179226 Free PMC article. Clinical Trial.
We also showed that there was a higher percentage of terminal effector memory T cells (P = 0.03) and LPS-stimulated ex vivo production of tumor necrosis factor-alpha (P = 0.04) in the WG group than in the RG group, which were positively associated with plasma alkylresorcinol conc …
We also showed that there was a higher percentage of terminal effector memory T cells (P = 0.03) and LPS-stimulated ex vivo production of tu …
Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans.
Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK, Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L. Meydani SN, et al. Aging (Albany NY). 2016 Jul;8(7):1416-31. doi: 10.18632/aging.100994. Aging (Albany NY). 2016. PMID: 27410480 Free PMC article. Clinical Trial.
Calorie restriction (CR) inhibits inflammation and slows aging in many animal species, but in rodents housed in pathogen-free facilities, CR impairs immunity against certain pathogens. However, little is known about the effects of long-term moderate CR on immune function i …
Calorie restriction (CR) inhibits inflammation and slows aging in many animal species, but in rodents housed in pathogen-free facilities, CR …
Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial.
Fontana L, Villareal DT, Das SK, Smith SR, Meydani SN, Pittas AG, Klein S, Bhapkar M, Rochon J, Ravussin E, Holloszy JO; CALERIE Study Group. Fontana L, et al. Among authors: meydani sn. Aging Cell. 2016 Feb;15(1):22-7. doi: 10.1111/acel.12400. Epub 2015 Oct 6. Aging Cell. 2016. PMID: 26443692 Free PMC article. Clinical Trial.
We conclude, on the basis of the present and previous findings, that, in contrast to rodents, humans do not respond to CR with a decrease in serum IGF-1 concentration or with a sustained and biological relevant increase in serum cortisol. However, long-term CR in humans si …
We conclude, on the basis of the present and previous findings, that, in contrast to rodents, humans do not respond to CR with a decrease in …
Patterns of antimicrobial use for respiratory tract infections in older residents of long-term care facilities.
Vergidis P, Hamer DH, Meydani SN, Dallal GE, Barlam TF. Vergidis P, et al. Among authors: meydani sn. J Am Geriatr Soc. 2011 Jun;59(6):1093-8. doi: 10.1111/j.1532-5415.2011.03406.x. Epub 2011 May 3. J Am Geriatr Soc. 2011. PMID: 21539527 Free PMC article.
OBJECTIVES: To describe patterns of antimicrobial use for respiratory tract infections (RTIs) in older residents of long-term care facilities (LTCFs). DESIGN: Data from a prospective, randomized, controlled study of the effect of vitamin E supplementation on RTIs conducted …
OBJECTIVES: To describe patterns of antimicrobial use for respiratory tract infections (RTIs) in older residents of long-term care fa …
Long-term care facilities: a cornucopia of viral pathogens.
Falsey AR, Dallal GE, Formica MA, Andolina GG, Hamer DH, Leka LL, Meydani SN. Falsey AR, et al. Among authors: meydani sn. J Am Geriatr Soc. 2008 Jul;56(7):1281-5. doi: 10.1111/j.1532-5415.2008.01775.x. Epub 2008 Jun 28. J Am Geriatr Soc. 2008. PMID: 18557966 Free PMC article. Clinical Trial.
OBJECTIVES: To determine the frequency and types of respiratory viruses circulating in Boston long-term care facilities (LTCFs) during a 3-year period. DESIGN: Observational. SETTING: Thirty-three Boston-area LTCFs over a 3-year period. PARTICIPANTS: Residents of long-t …
OBJECTIVES: To determine the frequency and types of respiratory viruses circulating in Boston long-term care facilities (LTCFs) durin …
Strategies, time, and costs associated with the recruitment and enrollment of nursing home residents for a micronutrient supplementation clinical trial.
Gismondi PM, Hamer DH, Leka LS, Dallal G, Fiatarone Singh MA, Meydani SN. Gismondi PM, et al. Among authors: meydani sn. J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1469-74. doi: 10.1093/gerona/60.11.1469. J Gerontol A Biol Sci Med Sci. 2005. PMID: 16339336 Clinical Trial.
The information available on strategies for the recruitment and screening of participants for such studies in long-term care facilities, as well as the financial and time costs for carrying out these investigations, is limited. ...
The information available on strategies for the recruitment and screening of participants for such studies in long-term care faciliti …
Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial.
Meydani SN, Leka LS, Fine BC, Dallal GE, Keusch GT, Singh MF, Hamer DH. Meydani SN, et al. JAMA. 2004 Aug 18;292(7):828-36. doi: 10.1001/jama.292.7.828. JAMA. 2004. PMID: 15315997 Free PMC article. Clinical Trial.
DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, placebo-controlled trial was conducted from April 1998 to August 2001 at 33 long-term care facilities in the Boston, Mass, area. A total of 617 persons aged at least 65 years and who met the study's eligibility …
DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, placebo-controlled trial was conducted from April 1998 to August 2001 at 33 l …
Metabolic, psychological, and health correlates of dietary restraint in healthy postmenopausal women.
Bathalon GP, Hays NP, Meydani SN, Dawson-Hughes B, Schaefer EJ, Lipman R, Nelson M, Greenberg AS, Roberts SB. Bathalon GP, et al. Among authors: meydani sn. J Gerontol A Biol Sci Med Sci. 2001 Apr;56(4):M206-11. doi: 10.1093/gerona/56.4.m206. J Gerontol A Biol Sci Med Sci. 2001. PMID: 11283192
BACKGROUND: Dietary restraint, a term used to describe the intentional control of food intake to prevent weight gain or promote weight loss, is commonly practiced by older adults, but little is known about its effects on physiology and metabolism. ...
BACKGROUND: Dietary restraint, a term used to describe the intentional control of food intake to prevent weight gain or promote weigh …
22 results