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Rationale, design, and results from RENO-DEFEND 1: a randomized, dose-finding study of the selective A1 adenosine antagonist SLV320 in patients hospitalized with acute heart failure.
Pang PS, Mehra M, Maggioni AP, Filippatos G, Middlebrooks J, Turlapaty P, Kazei D, Gheorghiade M; RENO-DEFEND Investigators. Pang PS, et al. Am Heart J. 2011 Jun;161(6):1012-23.e3. doi: 10.1016/j.ahj.2011.03.004. Am Heart J. 2011. PMID: 21641345 Clinical Trial.
BACKGROUND: Baseline renal impairment as well as worsening renal function during hospitalization is associated with worse short- and long-term outcomes in patients hospitalized for acute heart failure (AHF). ...
BACKGROUND: Baseline renal impairment as well as worsening renal function during hospitalization is associated with worse short- and long- …
Coordinated changes in mitochondrial function and biogenesis in healthy and diseased human skeletal muscle.
Garnier A, Fortin D, Zoll J, N'Guessan B, Mettauer B, Lampert E, Veksler V, Ventura-Clapier R. Garnier A, et al. Among authors: mettauer b. FASEB J. 2005 Jan;19(1):43-52. doi: 10.1096/fj.04-2173com. FASEB J. 2005. PMID: 15629894
We examined the transcriptional signaling cascade involved in the changes of mitochondrial biogenesis and mitochondrial function of skeletal muscle and of the exercise capacity of humans in response to long-term physical activity and chronic heart failure (CHF). Biopsy sam …
We examined the transcriptional signaling cascade involved in the changes of mitochondrial biogenesis and mitochondrial function of skeletal …
Improving exercise capacity, 6 wk training tends to reduce circulating endothelin after heart transplantation.
Doutreleau S, Piquard F, Lonsdorfer E, Rouyer O, Lampert E, Mettauer B, Richard R, Geny B. Doutreleau S, et al. Among authors: mettauer b. Clin Transplant. 2004 Dec;18(6):672-5. doi: 10.1111/j.1399-0012.2004.00265.x. Clin Transplant. 2004. PMID: 15516242
Short-term survival is no longer the pivotal issue after heart transplantation but, most heart-transplant (Htx) patients still present with increased circulating endothelin-1 (ET) and reduced exercise capacity. ...
Short-term survival is no longer the pivotal issue after heart transplantation but, most heart-transplant (Htx) patients still presen …
Immunosuppressive treatment affects cardiac and skeletal muscle mitochondria by the toxic effect of vehicle.
Sanchez H, Bigard X, Veksler V, Mettauer B, Lampert E, Lonsdorfer J, Ventura-Clapier R. Sanchez H, et al. Among authors: mettauer b. J Mol Cell Cardiol. 2000 Feb;32(2):323-31. doi: 10.1006/jmcc.1999.1078. J Mol Cell Cardiol. 2000. PMID: 10722807
In order to examine whether immunosuppressive treatment could be responsible for the reduced exercise capacity of heart transplant recipients (HTR), we studied the effects of long-term immunosuppressive treatment with cyclosporin A (CsA) and its vehicle (2/3 cremophor and …
In order to examine whether immunosuppressive treatment could be responsible for the reduced exercise capacity of heart transplant recipient …
Effect of short-term endurance training on exercise capacity, haemodynamics and atrial natriuretic peptide secretion in heart transplant recipients.
Geny B, Saini J, Mettauer B, Lampert E, Piquard F, Follenius M, Epailly E, Schnedecker B, Eisenmann B, Haberey P, Lonsdorfer J. Geny B, et al. Among authors: mettauer b. Eur J Appl Physiol Occup Physiol. 1996;73(3-4):259-66. doi: 10.1007/BF02425485. Eur J Appl Physiol Occup Physiol. 1996. PMID: 8781855
Central and peripheral factors have been proposed to explain such exercise limitation but, to date, the leading factors remain to be determined. We examined how a short-term endurance exercise training programme may improve exercise capacity after heart transplantation, an …
Central and peripheral factors have been proposed to explain such exercise limitation but, to date, the leading factors remain to be determi …
Parathyroid function in cardiac transplant patients: evaluation during physical exercise.
Brandenberger G, Schnedecker B, Spiegel K, Mettauer B, Geny B, Sacrez J, Lampert E, Lonsdorfer J. Brandenberger G, et al. Among authors: mettauer b. Eur J Appl Physiol Occup Physiol. 1995;70(5):401-6. doi: 10.1007/BF00618490. Eur J Appl Physiol Occup Physiol. 1995. PMID: 7671874
The survival rate of heart transplant patients has increased considerably since the development of new immunosuppressive drugs. In the long term, however, cardiac transplantation results in a high incidence of osteoporosis which represents a major functional handicap. ...
The survival rate of heart transplant patients has increased considerably since the development of new immunosuppressive drugs. In the long …
Differential long-term intrarenal and neurohormonal effects of captopril and prazosin in patients with chronic congestive heart failure: importance of initial plasma renin activity.
Mettauer B, Rouleau JL, Bichet D, Kortas C, Manzini C, Tremblay G, Chatterjee K. Mettauer B, et al. Circulation. 1986 Mar;73(3):492-502. doi: 10.1161/01.cir.73.3.492. Circulation. 1986. PMID: 3512121 Clinical Trial.
The only beneficial effect of prazosin was to increase water excretion from 49% to 59% (p less than .05). The long-term response to captopril was similar in patients with higher (greater than 2.5 ng/ml/hr) and lower renin levels. However, in patients with lower renin level …
The only beneficial effect of prazosin was to increase water excretion from 49% to 59% (p less than .05). The long-term response to c …
Detrimental arrhythmogenic and sustained beneficial hemodynamic effects of oral salbutamol in patients with chronic congestive heart failure.
Mettauer B, Rouleau JL, Burgess JH. Mettauer B, et al. Am Heart J. 1985 Apr;109(4):840-7. doi: 10.1016/0002-8703(85)90648-9. Am Heart J. 1985. PMID: 3984838
The long-term efficacy and potential side effects of oral sympathomimetic amines in the treatment of advanced congestive heart failure remain controversial. ...In the 12 patients who had long-term studies, the initial beneficial hemodynamic effects of salbutamol wer …
The long-term efficacy and potential side effects of oral sympathomimetic amines in the treatment of advanced congestive heart failur …
Lack of reflex increase in myocardial sympathetic tone after captopril: potential antianginal effect.
Daly P, Mettauer B, Rouleau JL, Cousineau D, Burgess JH. Daly P, et al. Among authors: mettauer b. Circulation. 1985 Feb;71(2):317-25. doi: 10.1161/01.cir.71.2.317. Circulation. 1985. PMID: 3880670 Clinical Trial.
In the first part of this study, captopril was given to 14 patients with angina and systolic arterial pressures of greater than 120 mm Hg. Over the short term, captopril decreased arterial blood pressure (from 110 +/- 18 to 98 +/- 18 mm Hg, p less than .01) without increas …
In the first part of this study, captopril was given to 14 patients with angina and systolic arterial pressures of greater than 120 mm Hg. O …
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