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Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells.
Clement K, McGill MR, Miousse IR, Young SG, Melnyk S, Koturbash I. Clement K, et al. Among authors: melnyk s. J Diet Suppl. 2023;20(6):950-962. doi: 10.1080/19390211.2022.2153957. Epub 2022 Dec 5. J Diet Suppl. 2023. PMID: 36469606 Free PMC article.
These changes were not associated with increased 5-methylcytosine content, did not result in changes of DNA methylation or re-distribution of DNA methylation patterns between the retrotransposons LINE-1 and HERV18, and were not associated with cytotoxicity. In conclusion, short- …
These changes were not associated with increased 5-methylcytosine content, did not result in changes of DNA methylation or re-distribution o …
Mechanical ventilation in Duchenne muscular dystrophy: A pilot project in Ukraine.
Tsarenko A, Trofimov I, Shatillo A, Kostiukova D, Kobylinskyi S, Melnyk S, Riiatchenko S, Berdykova Y, Morozova M, Marichuk M, Bondarenko S, Gutarev A, Toussaint M; Ukraine HMV Consortium. Tsarenko A, et al. Among authors: melnyk s. Pediatr Int. 2022 Jan;64(1):e15225. doi: 10.1111/ped.15225. Pediatr Int. 2022. PMID: 35727867
CONCLUSIONS: Implementation of HMV is feasible in DMD inpatients in Ukraine. In the short term, the Ukrainian parliament should recognize official centers for HMV, and define the funding policy of equipment for HMV, and its maintenance. ...
CONCLUSIONS: Implementation of HMV is feasible in DMD inpatients in Ukraine. In the short term, the Ukrainian parliament should recog …
Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology.
Frye RE, Cakir J, Rose S, Delhey L, Bennuri SC, Tippett M, Melnyk S, James SJ, Palmer RF, Austin C, Curtin P, Arora M. Frye RE, et al. Among authors: melnyk s. Mol Psychiatry. 2021 May;26(5):1561-1577. doi: 10.1038/s41380-020-00885-2. Epub 2020 Sep 22. Mol Psychiatry. 2021. PMID: 32963337 Free PMC article.
Our results suggest that prenatal exposure to PM(2.5) disrupts neurodevelopment and behavior through complex mechanisms, including long-term changes in mitochondrial respiration and that patterns of early development need to be considered when studying the influence of env …
Our results suggest that prenatal exposure to PM(2.5) disrupts neurodevelopment and behavior through complex mechanisms, including long-t …
Continuous stochastic processes with nonlocal memory.
Melnyk SS, Yampol'skii VA, Usatenko OV. Melnyk SS, et al. Phys Rev E. 2019 Nov;100(5-1):052141. doi: 10.1103/PhysRevE.100.052141. Phys Rev E. 2019. PMID: 31869899
As a starting point, we use the Markovian Gaussian Ornstein-Uhlenbeck process and introduce an integral memory term depending on the past of the process into an expression for the higher-order transition probability function and the stochastic differential equation. ...An …
As a starting point, we use the Markovian Gaussian Ornstein-Uhlenbeck process and introduce an integral memory term depending on the …
Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology.
Miousse IR, Pathak R, Garg S, Skinner CM, Melnyk S, Pavliv O, Hendrickson H, Landes RD, Lumen A, Tackett AJ, Deutz NEP, Hauer-Jensen M, Koturbash I. Miousse IR, et al. Among authors: melnyk s. Genes Nutr. 2017 Sep 6;12:22. doi: 10.1186/s12263-017-0576-0. eCollection 2017. Genes Nutr. 2017. PMID: 28904640 Free PMC article.
The aim of this study was to investigate the effects of short-term methionine dietary modulation on the proximal jejunum, the section of the gut specifically responsible for amino acid absorption, in a mouse model. ...The study design was developed in order to address the …
The aim of this study was to investigate the effects of short-term methionine dietary modulation on the proximal jejunum, the section …
Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart.
Seawright JW, Samman Y, Sridharan V, Mao XW, Cao M, Singh P, Melnyk S, Koturbash I, Nelson GA, Hauer-Jensen M, Boerma M. Seawright JW, et al. Among authors: melnyk s. PLoS One. 2017 Jul 5;12(7):e0180594. doi: 10.1371/journal.pone.0180594. eCollection 2017. PLoS One. 2017. PMID: 28678877 Free PMC article.
PURPOSE: Space travel is associated with an exposure to low-dose rate ionizing radiation and the microgravity environment, both of which may lead to impairments in cardiac function. We used a mouse model to determine short- and long-term cardiac effects to simulated microg …
PURPOSE: Space travel is associated with an exposure to low-dose rate ionizing radiation and the microgravity environment, both of which may …
Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart.
Sridharan V, Thomas CJ, Cao M, Melnyk SB, Pavliv O, Joseph J, Singh SP, Sharma S, Moros EG, Boerma M. Sridharan V, et al. Among authors: melnyk sb. Radiother Oncol. 2016 May;119(2):259-64. doi: 10.1016/j.radonc.2016.03.027. Epub 2016 Apr 9. Radiother Oncol. 2016. PMID: 27072940 Free PMC article.
CONCLUSIONS: This study found no early enhanced effects of radiation and sunitinib on cardiac function or structure. Long-term effects remain to be determined....
CONCLUSIONS: This study found no early enhanced effects of radiation and sunitinib on cardiac function or structure. Long-term effect …
A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure.
Sridharan V, Tripathi P, Aykin-Burns N, Krager KJ, Sharma SK, Moros EG, Melnyk SB, Pavliv O, Hauer-Jensen M, Boerma M. Sridharan V, et al. Among authors: melnyk sb. Radiat Res. 2015 Mar;183(3):357-66. doi: 10.1667/RR13915.1. Epub 2015 Feb 24. Radiat Res. 2015. PMID: 25710576 Free PMC article.
Our studies suggest that a single dose of tocotrienols protects against radiation-induced mitochondrial changes, but these effects are not sufficient against long-term alterations in cardiac function or remodeling....
Our studies suggest that a single dose of tocotrienols protects against radiation-induced mitochondrial changes, but these effects are not s …
13 results