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Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole.
PLoS Negl Trop Dis. 2020 Sep 24;14(9):e0008726. doi: 10.1371/journal.pntd.0008726. eCollection 2020 Sep.
PLoS Negl Trop Dis. 2020.
PMID: 32970692
Free PMC article.
4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.
Calvet CM, Choi JY, Thomas D, Suzuki B, Hirata K, Lostracco-Johnson S, de Mesquita LB, Nogueira A, Meuser-Batista M, Silva TA, Siqueira-Neto JL, Roush WR, de Souza Pereira MC, McKerrow JH, Podust LM.
Calvet CM, et al. Among authors: mckerrow jh.
PLoS Negl Trop Dis. 2017 Dec 27;11(12):e0006132. doi: 10.1371/journal.pntd.0006132. eCollection 2017 Dec.
PLoS Negl Trop Dis. 2017.
PMID: 29281643
Free PMC article.
In two acute models of Chagas disease, 9 and 12 drastically reduced parasitemia, increased survival of mice, and prevented liver and heart injury. None of the compounds produced long term sterile cure. In the less severe acute model using the transgenic CL-Brenner strain o …
In two acute models of Chagas disease, 9 and 12 drastically reduced parasitemia, increased survival of mice, and prevented liver and heart i …
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Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent.
Capparelli EV, Bricker-Ford R, Rogers MJ, McKerrow JH, Reed SL.
Capparelli EV, et al. Among authors: mckerrow jh.
Antimicrob Agents Chemother. 2016 Dec 27;61(1):e01947-16. doi: 10.1128/AAC.01947-16. Print 2017 Jan.
Antimicrob Agents Chemother. 2016.
PMID: 27821451
Free PMC article.
Clinical Trial.
The mean gold maximum concentration in plasma (C(max)) at day 7 was 0.312 mug/ml and the half-life (t(1/2)) 35 days, so steady-state blood levels would not be reached in short-term therapy. The highest concentration of gold, 13 muM (auranofin equivalent), or more than 25 t …
The mean gold maximum concentration in plasma (C(max)) at day 7 was 0.312 mug/ml and the half-life (t(1/2)) 35 days, so steady-state blood l …
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Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens).
Ramakrishnan L, Valdivia RH, McKerrow JH, Falkow S.
Ramakrishnan L, et al. Among authors: mckerrow jh.
Infect Immun. 1997 Feb;65(2):767-73. doi: 10.1128/iai.65.2.767-773.1997.
Infect Immun. 1997.
PMID: 9009340
Free PMC article.
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Ss40: the zinc endopeptidase secreted by infective larvae of Strongyloides stercoralis.
Brindley PJ, Gam AA, McKerrow JH, Neva FA.
Brindley PJ, et al. Among authors: mckerrow jh.
Exp Parasitol. 1995 Feb;80(1):1-7. doi: 10.1006/expr.1995.1001.
Exp Parasitol. 1995.
PMID: 7529715
The activity was not influenced by incubation with beta-mercaptoethanol at 22 degrees C, but was inactivated by incubation at 100 degrees C for 2 min. The enzyme, which we term Ss40, is immunogenic and stimulates humoral IgG antibodies during infection of humans; the activ …
The activity was not influenced by incubation with beta-mercaptoethanol at 22 degrees C, but was inactivated by incubation at 100 degrees C …
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