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Clinical Approach to Post-acute Sequelae After COVID-19 Infection and Vaccination.
Hulscher N, Procter BC, Wynn C, McCullough PA. Hulscher N, et al. Among authors: mccullough pa. Cureus. 2023 Nov 21;15(11):e49204. doi: 10.7759/cureus.49204. eCollection 2023 Nov. Cureus. 2023. PMID: 38024037 Free PMC article. Review.
We rationalized that these findings give support to the potential benefit of spike protein detoxification protocols in those with long-term post-infection and/or vaccine-induced complications. We propose a base spike detoxification protocol, composed of oral nattokinase, b …
We rationalized that these findings give support to the potential benefit of spike protein detoxification protocols in those with long-te …
Aortic Stenosis and Aortic Valve Replacement among Patients with Chronic Kidney Disease: A Narrative Review.
Rivera FB, Cu MVV, Cua SJ, De Luna DV, Lerma EV, McCullough PA, Kazory A, Collado FMS. Rivera FB, et al. Among authors: mccullough pa. Cardiorenal Med. 2023;13(1):74-90. doi: 10.1159/000529543. Epub 2023 Feb 22. Cardiorenal Med. 2023. PMID: 36812906 Free article. Review.
Patients with concomitant CKD and AS require special consideration as it is known that CKD is associated with progression of AS and poor long-term outcomes. AIMS AND OBJECTIVES: The aim of the study was to summarize and review the current existing literature on patients wi …
Patients with concomitant CKD and AS require special consideration as it is known that CKD is associated with progression of AS and poor lon …
Modulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19.
Sunderraj A, Cho C, Cai X, Gupta S, Mehta R, Isakova T, Leaf DE, Srivastava A; STOP-COVID Investigators. Sunderraj A, et al. Crit Care Explor. 2022 Aug 29;4(9):e0755. doi: 10.1097/CCE.0000000000000755. eCollection 2022 Sep. Crit Care Explor. 2022. PMID: 36050992 Free PMC article.
Effect modification by the number of risk factors was assessed through a multiplicative interaction term in the logistic regression model. Among the 5,037 patients included (mean age, 60.9 yr [ 14.7], 3,179 [63.1%] male), 1,786 (35.4%) died within 28 days. ...
Effect modification by the number of risk factors was assessed through a multiplicative interaction term in the logistic regression m …
Early multidrug treatment of SARS-CoV-2 infection (COVID-19) and reduced mortality among nursing home (or outpatient/ambulatory) residents.
Alexander PE, Armstrong R, Fareed G, Lotus J, Oskoui R, Prodromos C, Risch HA, Tenenbaum HC, Wax CM, Dara P, McCullough PA, Gill KK. Alexander PE, et al. Among authors: mccullough pa. Med Hypotheses. 2021 Aug;153:110622. doi: 10.1016/j.mehy.2021.110622. Epub 2021 Jun 5. Med Hypotheses. 2021. PMID: 34130113 Free PMC article.
Specifically, the provision of early multi-drug sequenced therapy with repurposed drugs will reduce hospitalization and death in elderly patients being cared for in long-term-care facilities. The most important implications of our hypothesis are: 1) hospitalizations and de …
Specifically, the provision of early multi-drug sequenced therapy with repurposed drugs will reduce hospitalization and death in elderly pat …
Nomenclature for Kidney Function from KDIGO: Shortcomings of Terminology Oversimplification.
Palazzuoli A, Tecson KM, Ronco C, McCullough PA. Palazzuoli A, et al. Among authors: mccullough pa. Cardiorenal Med. 2021;11(3):119-122. doi: 10.1159/000516615. Epub 2021 Jun 4. Cardiorenal Med. 2021. PMID: 34091445 Free article.
Finally, the terms "acute kidney injury" and "worsening renal function" are currently used interchangeably by nephrologists and cardiologists alike, and a universal adoption of one term will likely be a sizeable challenge. To be of greater benefit, we propose KD be used as …
Finally, the terms "acute kidney injury" and "worsening renal function" are currently used interchangeably by nephrologists and cardiologist …
Comparison of Survival in Patients With Clinically Significant Tricuspid Regurgitation With and Without Heart Failure (From the Optum Integrated File).
Barker CM, Cork DP, McCullough PA, Mehta HS, Van Houten J, Gunnarsson C, Ryan M, Irish W, Mollenkopf S, Verta P. Barker CM, et al. Among authors: mccullough pa. Am J Cardiol. 2021 Apr 1;144:125-130. doi: 10.1016/j.amjcard.2020.12.070. Epub 2020 Dec 30. Am J Cardiol. 2021. PMID: 33385352
Survival was estimated using a Cox hazard model with an interaction term for TR severity and adjusted for patient demographics and Elixhauser co-morbidities. ...
Survival was estimated using a Cox hazard model with an interaction term for TR severity and adjusted for patient demographics and El …
Global Phase 3 programme of vadadustat for treatment of anaemia of chronic kidney disease: rationale, study design and baseline characteristics of dialysis-dependent patients in the INNO2VATE trials.
Eckardt KU, Agarwal R, Farag YM, Jardine AG, Khawaja Z, Koury MJ, Luo W, Matsushita K, McCullough PA, Parfrey P, Ross G, Sarnak MJ, Vargo D, Winkelmayer WC, Chertow GM. Eckardt KU, et al. Among authors: mccullough pa. Nephrol Dial Transplant. 2021 Nov 9;36(11):2039-2048. doi: 10.1093/ndt/gfaa204. Nephrol Dial Transplant. 2021. PMID: 33188693 Free PMC article. Clinical Trial.
Study periods include correction/conversion (Weeks 0-23), maintenance (Weeks 24-52), long-term treatment (Weeks 53 to end of treatment) and safety follow-up. ...
Study periods include correction/conversion (Weeks 0-23), maintenance (Weeks 24-52), long-term treatment (Weeks 53 to end of treatmen …
Cardiovascular safety and efficacy of vadadustat for the treatment of anemia in non-dialysis-dependent CKD: Design and baseline characteristics.
Chertow GM, Pergola PE, Agarwal R, Block GA, Farag YMK, Jardine AG, Koury MJ, Luo W, Khawaja Z, Lewis EF, Matsushita K, McCullough PA, Parfrey PS, Wittes J, Walters KA, Tseng C, Lin T, Sarnak MJ, Vargo DL, Winkelmayer WC, Eckardt KU. Chertow GM, et al. Among authors: mccullough pa. Am Heart J. 2021 May;235:1-11. doi: 10.1016/j.ahj.2020.10.068. Epub 2020 Oct 30. Am Heart J. 2021. PMID: 33129989 Clinical Trial.
Trial periods in both trials include (1) correction/conversion (weeks 0-23); (2) maintenance (weeks 24-52); (3) long-term treatment (week 53 to end of treatment); and (4) safety follow-up (end-of-treatment to 4 weeks later). ...
Trial periods in both trials include (1) correction/conversion (weeks 0-23); (2) maintenance (weeks 24-52); (3) long-term treatment ( …
COVID-19-Associated Systemic Thromboembolism: A Case Report and Review of the Literature.
Mahajan P, Dass B, Radhakrishnan N, McCullough PA. Mahajan P, et al. Among authors: mccullough pa. Cardiorenal Med. 2020;10(6):462-469. doi: 10.1159/000511800. Epub 2020 Oct 22. Cardiorenal Med. 2020. PMID: 33091905 Free PMC article. Review.
Further studies are required to assess its role in improving long-term morbidity and mortality in these patients....
Further studies are required to assess its role in improving long-term morbidity and mortality in these patients....
Long-term safety and efficacy of sodium zirconium cyclosilicate for hyperkalaemia in patients with mild/moderate versus severe/end-stage chronic kidney disease: comparative results from an open-label, Phase 3 study.
Roger SD, Lavin PT, Lerma EV, McCullough PA, Butler J, Spinowitz BS, von Haehling S, Kosiborod M, Zhao J, Fishbane S, Packham DK. Roger SD, et al. Among authors: mccullough pa. Nephrol Dial Transplant. 2021 Jan 1;36(1):137-150. doi: 10.1093/ndt/gfz285. Nephrol Dial Transplant. 2021. PMID: 32030422 Free PMC article. Clinical Trial.
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