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Linking Air Pollution Exposure to Blood-Based Metabolic Features in a Community-Based Aging Cohort with and without Dementia.
Kalia V, Kulick ER, Vardarajan B, Gu Y, Manly JJ, Elkind MSV, Kaufman JD, Jones DP, Baccarelli AA, Mayeux R, Kioumourtzoglou MA, Miller GW. Kalia V, et al. Among authors: mayeux r. J Alzheimers Dis. 2023;96(3):1025-1040. doi: 10.3233/JAD-230122. J Alzheimers Dis. 2023. PMID: 37927256 Free PMC article.
BACKGROUND: Long-term exposure to air pollution has been associated with changes in levels of metabolites measured in the peripheral blood. ...OBJECTIVE: To study the relationship between the plasma metabolome and long-term exposure to three air pollutants: particul …
BACKGROUND: Long-term exposure to air pollution has been associated with changes in levels of metabolites measured in the peripheral …
Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults.
Walters S, Contreras AG, Eissman JM, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj AC, Peterson A, Gifford KA, Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang LS, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Hohman TJ, Dumitrescu L; Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Genetics Consortium, and Alzheimer’s Disease Sequencing Project. Walters S, et al. JAMA Neurol. 2023 Sep 1;80(9):929-939. doi: 10.1001/jamaneurol.2023.2169. JAMA Neurol. 2023. PMID: 37459083 Free PMC article.
The intersectional effect of race was modeled using an APOE sex race interaction term, assessing whether APOE sex interactions differed by race. Models were adjusted for age at baseline and corrected for multiple comparisons. ...
The intersectional effect of race was modeled using an APOE sex race interaction term, assessing whether APOE sex interactions differ …
Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease.
Siddiqui T, Cosacak MI, Popova S, Bhattarai P, Yilmaz E, Lee AJ, Min Y, Wang X, Allen M, İş Ö, Atasavum ZT, Rodriguez-Muela N, Vardarajan BN, Flaherty D, Teich AF, Santa-Maria I, Freudenberg U, Werner C, Tosto G, Mayeux R, Ertekin-Taner N, Kizil C. Siddiqui T, et al. Among authors: mayeux r. NPJ Regen Med. 2023 Jul 10;8(1):33. doi: 10.1038/s41536-023-00311-5. NPJ Regen Med. 2023. PMID: 37429840 Free PMC article.
Anti-neurogenic effects of Lcn2 was mediated by Slc22a17, blockage of which recapitulated the pro-neurogenicity by Ngfr. Long-term Ngfr expression reduced amyloid plaques and Tau phosphorylation. ...
Anti-neurogenic effects of Lcn2 was mediated by Slc22a17, blockage of which recapitulated the pro-neurogenicity by Ngfr. Long-term Ng …
Association of Dietary Prebiotic Consumption with Reduced Risk of Alzheimer's Disease in a Multiethnic Population.
Nishikawa M, Brickman AM, Manly JJ, Schupf N, Mayeux RP, Gu Y. Nishikawa M, et al. Among authors: mayeux rp. Curr Alzheimer Res. 2021;18(12):984-992. doi: 10.2174/1567205019666211222115142. Curr Alzheimer Res. 2021. PMID: 34951365 Free PMC article.
Effect modification by race/ethnicity, APOE genotype, and gender was tested by including an interaction term into the Cox models, as well as by stratified analyses. RESULTS: Among 1,837 participants (1,263 women [69%]; mean [SD] age = 76 [6.3] years), there were 391 incide …
Effect modification by race/ethnicity, APOE genotype, and gender was tested by including an interaction term into the Cox models, as …
Long-term exposure to air pollution and trajectories of cognitive decline among older adults.
Kulick ER, Wellenius GA, Boehme AK, Joyce NR, Schupf N, Kaufman JD, Mayeux R, Sacco RL, Manly JJ, Elkind MSV. Kulick ER, et al. Among authors: mayeux r. Neurology. 2020 Apr 28;94(17):e1782-e1792. doi: 10.1212/WNL.0000000000009314. Epub 2020 Apr 8. Neurology. 2020. PMID: 32269113 Free PMC article.
OBJECTIVE: To evaluate the association between long-term exposure to ambient air pollution and cognitive decline in older adults residing in an urban area. ...
OBJECTIVE: To evaluate the association between long-term exposure to ambient air pollution and cognitive decline in older adults resi …
Long-term exposure to ambient air pollution, APOE-epsilon4 status, and cognitive decline in a cohort of older adults in northern Manhattan.
Kulick ER, Elkind MSV, Boehme AK, Joyce NR, Schupf N, Kaufman JD, Mayeux R, Manly JJ, Wellenius GA. Kulick ER, et al. Among authors: mayeux r. Environ Int. 2020 Mar;136:105440. doi: 10.1016/j.envint.2019.105440. Epub 2020 Jan 8. Environ Int. 2020. PMID: 31926436 Free PMC article.
BACKGROUND: There is mounting evidence that long-term exposure to air pollution is related to accelerated cognitive decline in aging populations. ...OBJECTIVES: We assessed whether the association between long-term exposure to ambient air pollution and cognitive dec …
BACKGROUND: There is mounting evidence that long-term exposure to air pollution is related to accelerated cognitive decline in aging …
Alzheimer's disease research and development: a call for a new research roadmap.
Feldman HH, Haas M, Gandy S, Schoepp DD, Cross AJ, Mayeux R, Sperling RA, Fillit H, van de Hoef DL, Dougal S, Nye JS; One Mind for Research and the New York Academy of Sciences. Feldman HH, et al. Among authors: mayeux r. Ann N Y Acad Sci. 2014 Apr;1313:1-16. doi: 10.1111/nyas.12424. Ann N Y Acad Sci. 2014. PMID: 24754377
Currently available treatments for AD are symptomatic, with modest effect sizes and limited impact on longer term disease outcomes. There have been no newly approved pharmaceutical treatments in the last decade, despite enormous efforts to develop disease-modifying treatme …
Currently available treatments for AD are symptomatic, with modest effect sizes and limited impact on longer term disease outcomes. T …
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.
McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH. McKhann GM, et al. Among authors: mayeux r. Alzheimers Dement. 2011 May;7(3):263-9. doi: 10.1016/j.jalz.2011.03.005. Epub 2011 Apr 21. Alzheimers Dement. 2011. PMID: 21514250 Free PMC article.
On the basis of the past 27 years of experience, we made several changes in the clinical criteria for the diagnosis. We also retained the term possible AD dementia, but redefined it in a manner more focused than before. ...
On the basis of the past 27 years of experience, we made several changes in the clinical criteria for the diagnosis. We also retained the …
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.
Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St George-Hyslop P; Alzheimer's Disease Genetics Consortium; Cantwell LB, Dombroski BA, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Lunetta KL, Martin ER, Montine TJ, Goate AM, Blacker D, Tsuang DW, Beekly D, Cupples LA, Hakonarson H, Kukull W, Foroud TM, Haines J, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD. Jun G, et al. Among authors: mayeux r. Arch Neurol. 2010 Dec;67(12):1473-84. doi: 10.1001/archneurol.2010.201. Epub 2010 Aug 9. Arch Neurol. 2010. PMID: 20697030 Free PMC article.
Models with the main SNP effect, presence or absence of APOE epsilon4, and an interaction term showed significant interaction between presence or absence of APOE epsilon4 and PICALM. ...
Models with the main SNP effect, presence or absence of APOE epsilon4, and an interaction term showed significant interaction between …
Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort.
Brickman AM, Reitz C, Luchsinger JA, Manly JJ, Schupf N, Muraskin J, DeCarli C, Brown TR, Mayeux R. Brickman AM, et al. Among authors: mayeux r. Arch Neurol. 2010 May;67(5):564-9. doi: 10.1001/archneurol.2010.70. Arch Neurol. 2010. PMID: 20457955 Free PMC article.
Elevated blood pressure (BP) and fluctuation in BP may lead to cerebrovascular disease through ischemic changes and compromised cerebral autoregulation. OBJECTIVE: To determine the association of BP and long-term fluctuation in BP with cerebrovascular disease. DESIGN: A co …
Elevated blood pressure (BP) and fluctuation in BP may lead to cerebrovascular disease through ischemic changes and compromised cerebral aut …
24 results