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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.
Masutomi K, Possemato R, Wong JM, Currier JL, Tothova Z, Manola JB, Ganesan S, Lansdorp PM, Collins K, Hahn WC. Masutomi K, et al. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8222-7. doi: 10.1073/pnas.0503095102. Epub 2005 May 31. Proc Natl Acad Sci U S A. 2005. PMID: 15928077 Free PMC article.
Here, we show that suppression of the telomerase catalytic subunit [human telomerase reverse transcriptase (hTERT)] expression abrogates the cellular response to DNA double strand breaks. Loss of hTERT does not alter short-term telomere integrity but instead affects the ov …
Here, we show that suppression of the telomerase catalytic subunit [human telomerase reverse transcriptase (hTERT)] expression abrogates the …