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Associations of Sex, Race, and Apolipoprotein E Alleles With Multiple Domains of Cognition Among Older Adults.
Walters S, Contreras AG, Eissman JM, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez JB, Bush WS, Kunkle BW, Naj AC, Peterson A, Gifford KA, Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang LS, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Bennett DA, Barnes LL, Schneider JA, Crane PK, Hohman TJ, Dumitrescu L; Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Genetics Consortium, and Alzheimer’s Disease Sequencing Project. Walters S, et al. JAMA Neurol. 2023 Sep 1;80(9):929-939. doi: 10.1001/jamaneurol.2023.2169. JAMA Neurol. 2023. PMID: 37459083 Free PMC article.
The intersectional effect of race was modeled using an APOE sex race interaction term, assessing whether APOE sex interactions differed by race. Models were adjusted for age at baseline and corrected for multiple comparisons. ...
The intersectional effect of race was modeled using an APOE sex race interaction term, assessing whether APOE sex interactions differ …
CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy.
Battis K, Florio JB, Mante M, Lana A, Naumann I, Gauer C, Lambrecht V, Müller SJ, Cobo I, Fixsen B, Kim HY, Masliah E, Glass CK, Schlachetzki JCM, Rissman RA, Winkler J, Hoffmann A. Battis K, et al. Among authors: masliah e. J Neurosci. 2022 Oct 5;42(40):7673-7688. doi: 10.1523/JNEUROSCI.0417-22.2022. Epub 2022 Sep 6. J Neurosci. 2022. PMID: 36333098 Free PMC article.
Together, our findings provide insight into the complex, two-faced role of myeloid cells in the context of MSA emphasizing the importance to carefully balance the beneficial and adverse effects of CSF1R inhibition in different models of neurodegenerative disorders before its clin …
Together, our findings provide insight into the complex, two-faced role of myeloid cells in the context of MSA emphasizing the importance to …
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease.
Hatton C, Ghanem SS, Koss DJ, Abdi IY, Gibbons E, Guerreiro R, Bras J; International DLB Genetics Consortium; Walker L, Gelpi E, Heywood W, Outeiro TF, Attems J, McFarland R, Forsyth R, El-Agnaf OM, Erskine D. Hatton C, et al. Brain. 2022 May 24;145(4):1257-1263. doi: 10.1093/brain/awac002. Brain. 2022. PMID: 34999780 Free PMC article.
GALC variants are also associated with Lewy body diseases, an umbrella term for age-associated neurodegenerative diseases in which the protein alpha-synuclein aggregates into Lewy bodies. ...
GALC variants are also associated with Lewy body diseases, an umbrella term for age-associated neurodegenerative diseases in which th …
NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model.
Okamoto SI, Prikhodko O, Pina-Crespo J, Adame A, McKercher SR, Brill LM, Nakanishi N, Oh CK, Nakamura T, Masliah E, Lipton SA. Okamoto SI, et al. Among authors: masliah e. Neurobiol Dis. 2019 Jul;127:390-397. doi: 10.1016/j.nbd.2019.03.029. Epub 2019 Mar 27. Neurobiol Dis. 2019. PMID: 30928642 Free PMC article.
Accompanying this improvement was correction of activity in the p38 MAPK-TSC-Rheb-mTORC1-S6K1 pathway. Deficits in hippocampal long-term potentiation (LTP), histological loss of synapses, and behavioral fear conditioning in Tsc2(+/-) mice were all improved after treatment …
Accompanying this improvement was correction of activity in the p38 MAPK-TSC-Rheb-mTORC1-S6K1 pathway. Deficits in hippocampal long-term …
The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles.
Snow AD, Castillo GM, Nguyen BP, Choi PY, Cummings JA, Cam J, Hu Q, Lake T, Pan W, Kastin AJ, Kirschner DA, Wood SG, Rockenstein E, Masliah E, Lorimer S, Tanzi RE, Larsen L. Snow AD, et al. Among authors: masliah e. Sci Rep. 2019 Feb 6;9(1):561. doi: 10.1038/s41598-019-38645-0. Sci Rep. 2019. PMID: 30728442 Free PMC article.
One major identified specific polyphenol within PTI-00703 cat's claw was epicatechin-4beta-8-epicatechin (i.e. an epicatechin dimer known as proanthocyanidin B2) that markedly reduced brain plaque load and improved short-term memory in younger and older APP "plaque-produci …
One major identified specific polyphenol within PTI-00703 cat's claw was epicatechin-4beta-8-epicatechin (i.e. an epicatechin dimer known as …
NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.
Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, Huang X, Sultan A, McKercher SR, Ambasudhan R, Xu H, Wang Y, Geschwind DH, Roberts AJ, Terskikh AV, Rissman RA, Masliah E, Lipton SA, Nakanishi N. Tu S, et al. Among authors: masliah e. Nat Commun. 2017 Nov 14;8(1):1488. doi: 10.1038/s41467-017-01563-8. Nat Commun. 2017. PMID: 29133852 Free PMC article.
SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration.
Huang TY, Zhao Y, Jiang LL, Li X, Liu Y, Sun Y, Piña-Crespo JC, Zhu B, Masliah E, Willnow TE, Pasquale EB, Xu H. Huang TY, et al. Among authors: masliah e. J Exp Med. 2017 Dec 4;214(12):3669-3685. doi: 10.1084/jem.20171413. Epub 2017 Nov 7. J Exp Med. 2017. PMID: 29114064 Free PMC article.
Consistent with these findings, SORLA transgenic mice, compared with WT mice, exhibit decreased EphA4 activation and redistribution to postsynaptic densities, with milder deficits in long-term potentiation and memory induced by Abeta oligomers. Importantly, we detected ele …
Consistent with these findings, SORLA transgenic mice, compared with WT mice, exhibit decreased EphA4 activation and redistribution to posts …
Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease.
Zhang C, Kuo CC, Moghadam SH, Monte L, Campbell SN, Rice KC, Sawchenko PE, Masliah E, Rissman RA. Zhang C, et al. Among authors: masliah e. Alzheimers Dement. 2016 May;12(5):527-37. doi: 10.1016/j.jalz.2015.09.007. Epub 2015 Nov 7. Alzheimers Dement. 2016. PMID: 26555315 Free PMC article.
INTRODUCTION: Stress and corticotropin-releasing factor (CRF) have been implicated as mechanistically involved in Alzheimer's disease (AD), but agents that impact CRF signaling have not been carefully tested for therapeutic efficacy or long-term safety in animal models. ME …
INTRODUCTION: Stress and corticotropin-releasing factor (CRF) have been implicated as mechanistically involved in Alzheimer's disease (AD), …
Systemic Amyloid A Amyloidosis in Island Foxes (Urocyon littoralis): Severity and Risk Factors.
Gaffney PM, Witte C, Clifford DL, Imai DM, O'Brien TD, Trejo M, Liberta F, Annamalai K, Fändrich M, Masliah E, Munson L, Sigurdson CJ. Gaffney PM, et al. Among authors: masliah e. Vet Pathol. 2016 May;53(3):637-47. doi: 10.1177/0300985815604725. Epub 2015 Sep 29. Vet Pathol. 2016. PMID: 26419399 Free PMC article.
Univariate odds ratios (ORs) of severe renal AA amyloidosis were greater for short- and long-term captive foxes as compared with free-ranging foxes (ORs = 3.2, 3.7, respectively; overall P= .05) and for females as compared with males (OR = 2.9;P= .05). ...
Univariate odds ratios (ORs) of severe renal AA amyloidosis were greater for short- and long-term captive foxes as compared with free …
Recognition memory span in autopsy-confirmed Dementia with Lewy Bodies and Alzheimer's Disease.
Salmon DP, Heindel WC, Hamilton JM, Vincent Filoteo J, Cidambi V, Hansen LA, Masliah E, Galasko D. Salmon DP, et al. Among authors: masliah e. Neuropsychologia. 2015 Aug;75:548-55. doi: 10.1016/j.neuropsychologia.2015.07.014. Epub 2015 Jul 14. Neuropsychologia. 2015. PMID: 26184443 Free PMC article.
Evidence from patients with amnesia suggests that recognition memory span tasks engage both long-term memory (i.e., secondary memory) processes mediated by the diencephalic-medial temporal lobe memory system and working memory processes mediated by fronto-striatal systems. …
Evidence from patients with amnesia suggests that recognition memory span tasks engage both long-term memory (i.e., secondary memory) …
51 results