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Long-term personalized low FODMAP diet improves symptoms and maintains luminal Bifidobacteria abundance in irritable bowel syndrome.
Staudacher HM, Rossi M, Kaminski T, Dimidi E, Ralph FSE, Wilson B, Martin LD, Louis P, Lomer MCE, Irving PM, Whelan K. Staudacher HM, et al. Among authors: martin ld. Neurogastroenterol Motil. 2022 Apr;34(4):e14241. doi: 10.1111/nmo.14241. Epub 2021 Aug 24. Neurogastroenterol Motil. 2022. PMID: 34431172
Adequate relief of symptoms occurred in 5/18 (28%) at baseline and increased to 12/18 (67%) following long-term personalized low FODMAP diet (p = 0.039). There was a reduction in IBS-SSS total score between baseline (median 227, IQR 99) and long term (154, 89; p &lt …
Adequate relief of symptoms occurred in 5/18 (28%) at baseline and increased to 12/18 (67%) following long-term personalized low FODM …
Brain pathology caused in the neonatal macaque by short and prolonged exposures to anticonvulsant drugs.
Noguchi KK, Fuhler NA, Wang SH, Capuano S 3rd, Brunner KR, Larson S, Crosno K, Simmons HA, Mejia AF, Martin LD, Dissen GA, Brambrink A, Ikonomidou C. Noguchi KK, et al. Among authors: martin ld. Neurobiol Dis. 2021 Feb;149:105245. doi: 10.1016/j.nbd.2020.105245. Epub 2020 Dec 29. Neurobiol Dis. 2021. PMID: 33385515 Free PMC article.
In the developing brain they can cause neuronal and oligodendroglia apoptosis, impair synaptogenesis, inhibit neurogenesis and trigger long-term neurocognitive sequelae. In humans, the vulnerable period is projected to extend from the third trimester of pregnancy to the th …
In the developing brain they can cause neuronal and oligodendroglia apoptosis, impair synaptogenesis, inhibit neurogenesis and trigger long- …
In Pursuit of an Opioid-Free Pediatric Ambulatory Surgery Center: A Quality Improvement Initiative.
Franz AM, Martin LD, Liston DE, Latham GJ, Richards MJ, Low DK. Franz AM, et al. Among authors: martin ld. Anesth Analg. 2021 Mar 1;132(3):788-797. doi: 10.1213/ANE.0000000000004774. Anesth Analg. 2021. PMID: 32282383
BACKGROUND: Opioids have been a central component of routine adult and pediatric anesthesia for decades. However, the long-term effects of perioperative opioids are concerning. Recent studies show a 4.8%-6.5% incidence of persistent opioid use after surgery in older childr …
BACKGROUND: Opioids have been a central component of routine adult and pediatric anesthesia for decades. However, the long-term effec …
Viral opportunistic infections in Mauritian cynomolgus macaques undergoing allogeneic stem cell transplantation mirror human transplant infectious disease complications.
Wu HL, Weber WC, Shriver-Munsch C, Swanson T, Northrup M, Price H, Armantrout K, Robertson-LeVay M, Reed JS, Bateman KB, Mahyari E, Thomas A, Junell SL, Hobbs TR, Martin LD, MacAllister R, Bimber BN, Slifka MK, Legasse AW, Moats C, Axthelm MK, Smedley J, Lewis AD, Colgin L, Meyers G, Maziarz RT, Burwitz BJ, Stanton JJ, Sacha JB. Wu HL, et al. Among authors: martin ld. Xenotransplantation. 2020 Jul;27(4):e12578. doi: 10.1111/xen.12578. Epub 2020 Jan 13. Xenotransplantation. 2020. PMID: 31930750 Free PMC article.
However, in most cases, the reconstituted immune system, alone or in combination with short-term pharmacological intervention, exerted control over viral replication, suggesting engraftment of functional donor-derived immunity. Indeed, the donor-derived reconstituted immun …
However, in most cases, the reconstituted immune system, alone or in combination with short-term pharmacological intervention, exerte …
Candida albicans-associated sepsis in a pre-term neonatal rhesus macaque (Macaca mulatta).
Pecoraro HL, Berg MR, Dozier BL, Martin LD, McEvoy CT, Davies MH, Ducore R. Pecoraro HL, et al. Among authors: martin ld. J Med Primatol. 2019 Jun;48(3):186-188. doi: 10.1111/jmp.12401. Epub 2019 Feb 8. J Med Primatol. 2019. PMID: 30734326 Free PMC article.
Invasive Candida infections (ICI) have been associated with neurodevelopmental impairment or death in human pre-term neonates. Candidiasis in nonhuman primates is seen mostly in immunosuppressed animals, and ICI is not commonly reported. Here, we report a case of Candida a …
Invasive Candida infections (ICI) have been associated with neurodevelopmental impairment or death in human pre-term neonates. Candid …
Isoflurane exposure for three hours triggers apoptotic cell death in neonatal macaque brain.
Noguchi KK, Johnson SA, Dissen GA, Martin LD, Manzella FM, Schenning KJ, Olney JW, Brambrink AM. Noguchi KK, et al. Among authors: martin ld. Br J Anaesth. 2017 Sep 1;119(3):524-531. doi: 10.1093/bja/aex123. Br J Anaesth. 2017. PMID: 28969320 Free PMC article.
These results are relevant for clinical medicine, as many surgical and diagnostic procedures in children require anaesthesia durations similar to those modelled here. Further research is necessary to identify long-term neurobehavioural consequences of 3 h ISO exposure....
These results are relevant for clinical medicine, as many surgical and diagnostic procedures in children require anaesthesia durations simil …
Beyond the uterine environment: a nonhuman primate model to investigate maternal-fetal and neonatal outcomes following chronic intrauterine infection.
Kelleher MA, Liu Z, Wang X, Kroenke CD, Houser LA, Dozier BL, Martin LD, Waites KB, McEvoy C, Schelonka RL, Grigsby PL. Kelleher MA, et al. Among authors: martin ld. Pediatr Res. 2017 Aug;82(2):244-252. doi: 10.1038/pr.2017.57. Epub 2017 May 24. Pediatr Res. 2017. PMID: 28422948 Free PMC article.
Neonates were delivered by elective hysterotomy at 135-147 dGA (term=167d), stabilized, and cared for in our nonhuman primate neonatal intensive care unit. Neonatal reflex behaviors were assessed from birth, and fetal and postnatal brain magnetic resonance imaging ( …
Neonates were delivered by elective hysterotomy at 135-147 dGA (term=167d), stabilized, and cared for in our nonhuman primate neonata …
Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques.
Coleman K, Robertson ND, Dissen GA, Neuringer MD, Martin LD, Cuzon Carlson VC, Kroenke C, Fair D, Brambrink AM. Coleman K, et al. Among authors: martin ld. Anesthesiology. 2017 Jan;126(1):74-84. doi: 10.1097/ALN.0000000000001383. Anesthesiology. 2017. PMID: 27749311 Free PMC article.
CONCLUSIONS: Neonatal exposure to isoflurane, particularly when repeated, has long-term behavioral consequences affecting both motor and socioemotional aspects of behavior....
CONCLUSIONS: Neonatal exposure to isoflurane, particularly when repeated, has long-term behavioral consequences affecting both motor …
Lithium Protects Against Anaesthesia Neurotoxicity In The Infant Primate Brain.
Noguchi KK, Johnson SA, Kristich LE, Martin LD, Dissen GA, Olsen EA, Olney JW, Brambrink AM. Noguchi KK, et al. Among authors: martin ld. Sci Rep. 2016 Mar 8;6:22427. doi: 10.1038/srep22427. Sci Rep. 2016. PMID: 26951756 Free PMC article.
Exposure of infant animals, including non-human primates (NHPs), to anaesthetic drugs causes apoptotic death of neurons and oligodendrocytes (oligos) and results in long-term neurodevelopmental impairment (NDI). Moreover, retrospective clinical studies document an associat …
Exposure of infant animals, including non-human primates (NHPs), to anaesthetic drugs causes apoptotic death of neurons and oligodendrocytes …
In utero exposure to zidovudine and heart anomalies in the ANRS French perinatal cohort and the nested PRIMEVA randomized trial.
Sibiude J, Le Chenadec J, Bonnet D, Tubiana R, Faye A, Dollfus C, Mandelbrot L, Delmas S, Lelong N, Khoshnood B, Warszawski J, Blanche S; French National Agency for Research on AIDS and Viral Hepatitis French Perinatal Cohort/Protease Inhibitor Monotherapy Evaluation Trial. Sibiude J, et al. Clin Infect Dis. 2015 Jul 15;61(2):270-80. doi: 10.1093/cid/civ260. Epub 2015 Apr 1. Clin Infect Dis. 2015. PMID: 25838291 Clinical Trial.
A potential common mechanism, including the involvement of mitochondrial dysfunction, must be explored, and long-term consequences on cardiac function warrant specific attention. ...
A potential common mechanism, including the involvement of mitochondrial dysfunction, must be explored, and long-term consequences on …
14 results