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Toxicological Profiling and Long-Term Effects of Bare, PEGylated- and Galacto-Oligosaccharide-Functionalized Mesoporous Silica Nanoparticles.
Barguilla I, Candela-Noguera V, Oliver P, Annangi B, Díez P, Aznar E, Martínez-Máñez R, Marcos R, Hernández A, Marcos MD. Barguilla I, et al. Among authors: martinez manez r. Int J Mol Sci. 2023 Nov 10;24(22):16158. doi: 10.3390/ijms242216158. Int J Mol Sci. 2023. PMID: 38003350 Free PMC article.
In this study, bare MSNs, PEGylated MSNs (MSNs-PEG), and galacto-oligosaccharide-functionalized MSNs (MSNs-GAL) are synthesized and characterized to assess their genotoxicity and transforming ability on human lung epithelial BEAS-2B cells in short- (48 h) and long-term (8 …
In this study, bare MSNs, PEGylated MSNs (MSNs-PEG), and galacto-oligosaccharide-functionalized MSNs (MSNs-GAL) are synthesized and characte …
Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice.
Lérida-Viso A, Estepa-Fernández A, Morellá-Aucejo Á, Lozano-Torres B, Alfonso M, Blandez JF, Bisbal V, Sepúlveda P, García-Fernández A, Orzáez M, Martínez-Máñez R. Lérida-Viso A, et al. Among authors: martinez manez r. Pharmacol Res. 2022 Sep;183:106356. doi: 10.1016/j.phrs.2022.106356. Epub 2022 Jul 14. Pharmacol Res. 2022. PMID: 35843569
Cardiotoxicity is a well-known limiting factor of anticancer treatment with doxorubicin (DOX), a very effective anthracycline widely used as antitumoral therapy in clinical practice, that leads to long-term morbidity and mortality. DOX exposure severely affects the populat …
Cardiotoxicity is a well-known limiting factor of anticancer treatment with doxorubicin (DOX), a very effective anthracycline widely used as …
Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic.
Galiana I, Lozano-Torres B, Sancho M, Alfonso M, Bernardos A, Bisbal V, Serrano M, Martínez-Máñez R, Orzáez M. Galiana I, et al. Among authors: martinez manez r. J Control Release. 2020 Jul 10;323:624-634. doi: 10.1016/j.jconrel.2020.04.045. Epub 2020 May 4. J Control Release. 2020. PMID: 32376460 Free article.
The induction of senescence produces a stable cell cycle arrest in cancer cells, thereby inhibiting tumor growth; however, the incomplete immune cell-mediated clearance of senescent cells may favor tumor relapse, limiting the long-term anti-tumorigenic effect of such drugs …
The induction of senescence produces a stable cell cycle arrest in cancer cells, thereby inhibiting tumor growth; however, the incomplete im …
Electrospun Antimicrobial Films of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Containing Eugenol Essential Oil Encapsulated in Mesoporous Silica Nanoparticles.
Melendez-Rodriguez B, Figueroa-Lopez KJ, Bernardos A, Martínez-Máñez R, Cabedo L, Torres-Giner S, Lagaron JM. Melendez-Rodriguez B, et al. Among authors: martinez manez r. Nanomaterials (Basel). 2019 Feb 8;9(2):227. doi: 10.3390/nano9020227. Nanomaterials (Basel). 2019. PMID: 30744000 Free PMC article.
The main goal of this study was to develop poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) films with long-term antimicrobial capacity of interest in food packaging applications. ...
The main goal of this study was to develop poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) films with long-term antimicrobial cap …
Cytotoxicity, genotoxicity, transplacental transfer and tissue disposition in pregnant rats mediated by nanoparticles: the case of magnetic core mesoporous silica nanoparticles.
Pinto SR, Helal-Neto E, Paumgartten F, Felzenswalb I, Araujo-Lima CF, Martínez-Máñez R, Santos-Oliveira R. Pinto SR, et al. Among authors: martinez manez r. Artif Cells Nanomed Biotechnol. 2018;46(sup2):527-538. doi: 10.1080/21691401.2018.1460603. Epub 2018 Apr 24. Artif Cells Nanomed Biotechnol. 2018. PMID: 29688037
However, there are few studies about the physical potential of long-term use or use in special conditions such as chronic, AIDS, pregnant women and other special health circumstances. ...
However, there are few studies about the physical potential of long-term use or use in special conditions such as chronic, AIDS, preg …