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Molecular characterization of a t(2;7) translocation linking CDK6 to the IGK locus in CD5(-) monoclonal B-cell lymphocytosis.
Parker E, Macdonald JR, Wang C. Parker E, et al. Among authors: macdonald jr. Cancer Genet. 2011 May;204(5):260-4. doi: 10.1016/j.cancergen.2011.03.004. Cancer Genet. 2011. PMID: 21665179
The term monoclonal B-cell lymphocytosis (MBL) is used to characterize individuals with a circulating population of clonal B-cells and no other features of a lymphoproliferative disorder. ...
The term monoclonal B-cell lymphocytosis (MBL) is used to characterize individuals with a circulating population of clonal B-cells an …
A phase I and pharmacokinetic study of irofulven and capecitabine administered every 2 weeks in patients with advanced solid tumors.
Alexandre J, Kahatt C, Bertheault-Cvitkovic F, Faivre S, Shibata S, Hilgers W, Goldwasser F, Lokiec F, Raymond E, Weems G, Shah A, MacDonald JR, Cvitkovic E. Alexandre J, et al. Among authors: macdonald jr. Invest New Drugs. 2007 Oct;25(5):453-62. doi: 10.1007/s10637-007-9071-6. Epub 2007 Jul 13. Invest New Drugs. 2007. PMID: 17628744 Clinical Trial.
Antitumor activity was observed; two partial responses were noted in thyroid carcinoma (DL1, DL4); one unconfirmed partial response was observed in a patient with nasopharyngeal carcinoma, (DL3); 12 patients had disease stabilization >3 months; of eight patients with hormone r …
Antitumor activity was observed; two partial responses were noted in thyroid carcinoma (DL1, DL4); one unconfirmed partial response was obse …
Short-term 17-beta-estradiol administration does not affect metabolism in young males.
Tarnopolsky MA, Roy BD, MacDonald JR, McKenzie S, Martin J, Ettinger S. Tarnopolsky MA, et al. Among authors: macdonald jr. Int J Sports Med. 2001 Apr;22(3):175-80. doi: 10.1055/s-2001-16380. Int J Sports Med. 2001. PMID: 11354519 Clinical Trial.
Therewere no effects of E2 treatment upon any of the other measured variables including muscle glycogen: (E2 - PRE = 529.3 --> POST = 237.9; PL-PRE = 582.2 --> POST = 262.4 mmol.kg(-1) [dm]). We concluded that short-term E2 treatment increased plasma E2 to female fol …
Therewere no effects of E2 treatment upon any of the other measured variables including muscle glycogen: (E2 - PRE = 529.3 --> POST = 237 …
Muscle performance and enzymatic adaptations to sprint interval training.
MacDougall JD, Hicks AL, MacDonald JR, McKelvie RS, Green HJ, Smith KM. MacDougall JD, et al. Among authors: macdonald jr. J Appl Physiol (1985). 1998 Jun;84(6):2138-42. doi: 10.1152/jappl.1998.84.6.2138. J Appl Physiol (1985). 1998. PMID: 9609810 Free article. Clinical Trial.
It was concluded that relatively brief but intense sprint training can result in an increase in both glycolytic and oxidative enzyme activity, maximum short-term power output, and VO2 max....
It was concluded that relatively brief but intense sprint training can result in an increase in both glycolytic and oxidative enzyme activit …
A new paradigm for type 2 diabetes mellitus: could it be a disease of the foregut?
Hickey MS, Pories WJ, MacDonald KG Jr, Cory KA, Dohm GL, Swanson MS, Israel RG, Barakat HA, Considine RV, Caro JF, Houmard JA. Hickey MS, et al. Among authors: macdonald kg jr. Ann Surg. 1998 May;227(5):637-43; discussion 643-4. doi: 10.1097/00000658-199805000-00004. Ann Surg. 1998. PMID: 9605655 Free PMC article.
Instead, bypassing the foregut and reducing food intake produce the profound long-term alterations in glucose metabolism and insulin action. These findings suggest that our current paradigms of type 2 diabetes mellitus deserve review. ...
Instead, bypassing the foregut and reducing food intake produce the profound long-term alterations in glucose metabolism and insulin …
Impedance spectroscopy.
Macdonald JR. Macdonald JR. Ann Biomed Eng. 1992;20(3):289-305. doi: 10.1007/BF02368532. Ann Biomed Eng. 1992. PMID: 1443825
Impedance spectroscopy (IS) is a general term that subsumes the small-signal measurement of the linear electrical response of a material of interest (including electrode effects) and the subsequent analysis of the response to yield useful information about the physicochemi …
Impedance spectroscopy (IS) is a general term that subsumes the small-signal measurement of the linear electrical response of a mater …
Prehospital endotracheal tube airway or esophageal gastric tube airway: a critical comparison.
Shea SR, MacDonald JR, Gruzinski G. Shea SR, et al. Among authors: macdonald jr. Ann Emerg Med. 1985 Feb;14(2):102-12. doi: 10.1016/s0196-0644(85)81069-6. Ann Emerg Med. 1985. PMID: 3970393
In the survival study group of 296 patients, 148 patients received an endotracheal tube airway (ETA) and 148 patients received an esophageal gastric tube airway (EGTA), the improved version of the esophageal obturator airway (EOA). Survival rates, both short term (ETA = 35 …
In the survival study group of 296 patients, 148 patients received an endotracheal tube airway (ETA) and 148 patients received an esophageal …
Hepatic cysteamine and non-protein sulfhydryl levels following cystamine or cysteamine treatment of galactosamine-poisoned rats.
MacDonald JR, Gandolfi AJ, Sipes IG. MacDonald JR, et al. Drug Chem Toxicol. 1985;8(6):483-94. doi: 10.3109/01480548509041071. Drug Chem Toxicol. 1985. PMID: 4092620
However, neither cystamine nor cysteamine prevented NPSH levels from falling to 3 nanomoles/mg tissue 24 hr after GAL. Hepatoprotective treatments did not affect long term NPSH status in GAL-poisoned rats. However, transient NPSH increases, due to the intrahepatic presence …
However, neither cystamine nor cysteamine prevented NPSH levels from falling to 3 nanomoles/mg tissue 24 hr after GAL. Hepatoprotective trea …