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IGFBP-2 partly mediates the early metabolic improvements caused by bariatric surgery.
Faramia J, Hao Z, Mumphrey MB, Townsend RL, Miard S, Carreau AM, Nadeau M, Frisch F, Baraboi ED, Grenier-Larouche T, Noll C, Li M, Biertho L, Marceau S, Hould FS, Lebel S, Morrison CD, Münzberg H, Richard D, Carpentier AC, Tchernof A, Berthoud HR, Picard F. Faramia J, et al. Among authors: munzberg h. Cell Rep Med. 2021 Apr 20;2(4):100248. doi: 10.1016/j.xcrm.2021.100248. eCollection 2021 Apr 20. Cell Rep Med. 2021. PMID: 33948578 Free PMC article.
In mice, Igfbp2 deficiency significantly impairs surgery-induced loss in adiposity and early improvement in insulin sensitivity but does not affect long-term enhancement in glucose homeostasis. This study demonstrates that the modulation of circulating IGFBP-2 may play a r …
In mice, Igfbp2 deficiency significantly impairs surgery-induced loss in adiposity and early improvement in insulin sensitivity but does not …
Testing Effects of Chronic Chemogenetic Neuronal Stimulation on Energy Balance by Indirect Calorimetry.
Yu S, Münzberg H. Yu S, et al. Among authors: munzberg h. Bio Protoc. 2018 Apr 20;8(8):e2811. doi: 10.21769/BioProtoc.2811. Bio Protoc. 2018. PMID: 29951570 Free PMC article.
Here we describe the detailed protocol of how we used indirect calorimetry to study the outcome of chronic stimulation of POA LepRb neurons. This protocol can be adapted to study long-term metabolic and behavioral consequences of other neuronal modulations, with possible m …
Here we describe the detailed protocol of how we used indirect calorimetry to study the outcome of chronic stimulation of POA LepRb neurons. …
RYGB Produces more Sustained Body Weight Loss and Improvement of Glycemic Control Compared with VSG in the Diet-Induced Obese Mouse Model.
Hao Z, Townsend RL, Mumphrey MB, Morrison CD, Münzberg H, Berthoud HR. Hao Z, et al. Among authors: munzberg h. Obes Surg. 2017 Sep;27(9):2424-2433. doi: 10.1007/s11695-017-2660-3. Obes Surg. 2017. PMID: 28386755 Free PMC article.
BACKGROUND: Weight regain and type-2 diabetes relapse has been reported in a significant proportion of vertical sleeve gastrectomy (VSG) patients in some studies, but definitive conclusions regarding the long-term comparative effectiveness of VSG and Roux-en-Y gastric bypa …
BACKGROUND: Weight regain and type-2 diabetes relapse has been reported in a significant proportion of vertical sleeve gastrectomy (VSG) pat …
Neural Control of Energy Expenditure.
Münzberg H, Qualls-Creekmore E, Berthoud HR, Morrison CD, Yu S. Münzberg H, et al. Handb Exp Pharmacol. 2016;233:173-94. doi: 10.1007/164_2015_33. Handb Exp Pharmacol. 2016. PMID: 26578523 Free PMC article. Review.
Many strategies to control body weight focus on a permanent modification of food intake with limited success in the long term. Metabolism or energy expenditure is the other side of the coin for the regulation of body weight, and strategies to enhance energy expenditure are …
Many strategies to control body weight focus on a permanent modification of food intake with limited success in the long term. Metabo …
Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus.
Leshan RL, Louis GW, Jo YH, Rhodes CJ, Münzberg H, Myers MG Jr. Leshan RL, et al. Among authors: munzberg h. J Neurosci. 2009 Mar 11;29(10):3138-47. doi: 10.1523/JNEUROSCI.0155-09.2009. J Neurosci. 2009. PMID: 19279251 Free PMC article.
Leptin acts via its receptor (LepRb) on specific CNS neurons to signal the adequacy of long-term energy stores, thereby permitting the expenditure of resources on energy-intensive processes such as reproduction. ...
Leptin acts via its receptor (LepRb) on specific CNS neurons to signal the adequacy of long-term energy stores, thereby permitting th …
The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms.
Gong Y, Ishida-Takahashi R, Villanueva EC, Fingar DC, Münzberg H, Myers MG Jr. Gong Y, et al. Among authors: munzberg h. J Biol Chem. 2007 Oct 19;282(42):31019-27. doi: 10.1074/jbc.M702838200. Epub 2007 Aug 28. J Biol Chem. 2007. PMID: 17726024 Free article.
Tyr(1138) and STAT3 attenuate STAT5-dependent transcription over the long-term, however. In contrast, Tyr(985) (the LepRb phosphorylation site required for ERK activation) mediates the phosphorylation of the ribosomal S6 kinase (RSK) and S6, as well as cap-dependent transl …
Tyr(1138) and STAT3 attenuate STAT5-dependent transcription over the long-term, however. In contrast, Tyr(985) (the LepRb phosphoryla …