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Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer's disease.
Gonzalez-Ortiz F, Kirsebom BE, Contador J, Tanley JE, Selnes P, Gísladóttir B, Pålhaugen L, Suhr Hemminghyth M, Jarholm J, Skogseth R, Bråthen G, Grøndtvedt G, Bjørnerud A, Tecelao S, Waterloo K, Aarsland D, Fernández-Lebrero A, García-Escobar G, Navalpotro-Gómez I, Turton M, Hesthamar A, Kac PR, Nilsson J, Luchsinger J, Hayden KM, Harrison P, Puig-Pijoan A, Zetterberg H, Hughes TM, Suárez-Calvet M, Karikari TK, Fladby T, Blennow K. Gonzalez-Ortiz F, et al. Among authors: luchsinger j. Nat Commun. 2024 Apr 4;15(1):2908. doi: 10.1038/s41467-024-47286-5. Nat Commun. 2024. PMID: 38575616 Free PMC article.
Here we show that blood-based BD-tau is a biomarker for identifying Abeta-positive individuals at risk of short-term cognitive decline and atrophy, with implications for clinical trials and implementation of anti-Abeta therapies....
Here we show that blood-based BD-tau is a biomarker for identifying Abeta-positive individuals at risk of short-term cognitive declin …
Prevalence of Distal Symmetrical Polyneuropathy by Diabetes Prevention Program Treatment Group, Diabetes Status, Duration of Diabetes, and Cumulative Glycemic Exposure.
Lee CG, Ciarleglio A, Edelstein SL, Crandall JP, Dabelea D, Goldberg RB, Kahn SE, Knowler WC, Ma MT, White NH, Herman WH; Diabetes Prevention Program Research Group. Lee CG, et al. Diabetes Care. 2024 May 1;47(5):810-817. doi: 10.2337/dc23-2009. Diabetes Care. 2024. PMID: 38502874 Clinical Trial.
CONCLUSIONS: The likelihood of DSPN was similar across DPP treatment groups but higher for those with diabetes, longer diabetes duration, and higher cumulative glycemic exposure. ILS may have long-term benefits on DSPN for older adults....
CONCLUSIONS: The likelihood of DSPN was similar across DPP treatment groups but higher for those with diabetes, longer diabetes duration, an …
Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Rasouli N, Younes N, Ghosh A, Albu J, Cohen RM, DeFronzo RA, Diaz E, Sayyed Kassem L, Luchsinger JA, McGill JB, Sivitz WI, Tamborlane WV, Utzschneider KM, Kahn SE; GRADE Research Group. Rasouli N, et al. Among authors: luchsinger ja. Diabetes Care. 2024 Apr 1;47(4):580-588. doi: 10.2337/dc23-1070. Diabetes Care. 2024. PMID: 38211595 Clinical Trial.
OBJECTIVE: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and sitagliptin) when added to metformin on insulin sensitivity and beta-cell function. ...After adjustment for HOMA2-%S to obtain an estimate of …
OBJECTIVE: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and si …
Impact of Insulin Sensitivity and β-Cell Function Over Time on Glycemic Outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE): Differential Treatment Effects of Dual Therapy.
Utzschneider KM, Younes N, Butera NM, Balasubramanyam A, Bergenstal RM, Barzilay J, DeSouza C, DeFronzo RA, Elasy T, Krakoff J, Kahn SE, Rasouli N, Valencia WM, Sivitz WI; GRADE Research Group. Utzschneider KM, et al. Diabetes Care. 2024 Apr 1;47(4):571-579. doi: 10.2337/dc23-1059. Diabetes Care. 2024. PMID: 38190619 Clinical Trial.
CONCLUSIONS: Insulin sensitivity and beta-cell function affected treatment outcomes irrespective of drug assignment, with greater impact in the sitagliptin group on initial (short-term) HbA1c response in comparison with the glimepiride and liraglutide groups....
CONCLUSIONS: Insulin sensitivity and beta-cell function affected treatment outcomes irrespective of drug assignment, with greater impact in …
Changes in Nursing Home Use Following Medicaid-Supported Expanded Access to Home- and Community-Based Services for Older Adults With Dementia.
Harrison JM, Sheng F, Josberger RE, Liu HH, Stone PW, Luchsinger JA, Dick AW. Harrison JM, et al. Among authors: luchsinger ja. JAMA Netw Open. 2023 Jul 3;6(7):e2322520. doi: 10.1001/jamanetworkopen.2023.22520. JAMA Netw Open. 2023. PMID: 37428503 Free PMC article.
IMPORTANCE: New York State's Medicaid managed long-term care (MLTC) program expanded access to home- and community-based services, providing an alternative to nursing home care for people with dementia. Between 2012 and 2015, the state implemented mandatory MLTC for dual M …
IMPORTANCE: New York State's Medicaid managed long-term care (MLTC) program expanded access to home- and community-based services, pr …
Unexpected lucidity in dementia: application of qualitative methods to develop an informant-reported lucidity measure.
Ramirez M, Teresi JA, Ellis J, Gonzalez-Lopez P, Silver S, Rutigliano M, Vidal-Manzano J, Boratgis G, Devanand DP, van Meer I, Bhatti I, Bhatti U, Luchsinger JA. Ramirez M, et al. Among authors: luchsinger ja. Aging Ment Health. 2023 Nov-Dec;27(12):2395-2402. doi: 10.1080/13607863.2023.2207167. Epub 2023 May 5. Aging Ment Health. 2023. PMID: 37145967
Modified focus groups were conducted with 20 staff and 10 family members using a web-based survey. Themes included reaction when hearing the term; words that come to mind; description of and first reaction to referenced or observed 'lucidity' events. ...
Modified focus groups were conducted with 20 staff and 10 family members using a web-based survey. Themes included reaction when hearing the …
The 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) score and diabetes risk in the Diabetes Prevention Program Outcomes Study (DPPOS).
Shams-White MM, Tjaden AH, Edelstein SL, Bassiouni S, Kahle LL, Kim C, Pi-Sunyer X, Temple KA, Venditti EM, Reedy J, Heckman-Stoddard BM; DPP Research Group. Shams-White MM, et al. BMC Nutr. 2022 Sep 21;8(1):105. doi: 10.1186/s40795-022-00596-7. BMC Nutr. 2022. PMID: 36131333 Free PMC article.
Score changes from years 0-1 and time-dependent Score changes in ILS and PLB remained associated with lower risk through year 15. CONCLUSIONS: Score improvements were associated with long-term, lower diabetes risk among high-risk adults randomized to ILS and PLB, but not M …
Score changes from years 0-1 and time-dependent Score changes in ILS and PLB remained associated with lower risk through year 15. CONCLUSION …
Association of cognition with leptin and vascular endothelial growth factor in individuals with type 2 diabetes mellitus.
Espeland MA, Evans JK, Carmichael O, Luchsinger JA, Marcovina SM, Neiberg R, Johnson KC, Kahn SE, Hayden KM; Action for Health in Diabetes (Look AHEAD) MIND Ancillary Study Group. Espeland MA, et al. Among authors: luchsinger ja. Obesity (Silver Spring). 2022 Sep;30(9):1863-1874. doi: 10.1002/oby.23495. Epub 2022 Aug 3. Obesity (Silver Spring). 2022. PMID: 35920161 Free PMC article. Clinical Trial.
CONCLUSIONS: Alterations in two weight-sensitive proangiogenic cytokines did not account for the long-term adverse effects of ILI on cognitive function among adults with diabetes and either obesity or cardiovascular disease....
CONCLUSIONS: Alterations in two weight-sensitive proangiogenic cytokines did not account for the long-term adverse effects of ILI on …
The Impact of Physical Activity on the Prevention of Type 2 Diabetes: Evidence and Lessons Learned From the Diabetes Prevention Program, a Long-Standing Clinical Trial Incorporating Subjective and Objective Activity Measures.
Kriska AM, Rockette-Wagner B, Edelstein SL, Bray GA, Delahanty LM, Hoskin MA, Horton ES, Venditti EM, Knowler WC; DPP Research Group. Kriska AM, et al. Diabetes Care. 2021 Jan;44(1):43-49. doi: 10.2337/dc20-1129. Epub 2020 Nov 10. Diabetes Care. 2021. PMID: 33444158 Free PMC article. Clinical Trial.
Collection of self-reported physical activity (PA) (yearly) with cross-sectional objective PA (in follow-up) allowed for examination of PA and its long-term impact on diabetes prevention. RESEARCH DESIGN AND METHODS: Yearly self-reported PA and diabetes assessment and oral …
Collection of self-reported physical activity (PA) (yearly) with cross-sectional objective PA (in follow-up) allowed for examination of PA a …
Association of Intensive Lifestyle and Metformin Interventions With Frailty in the Diabetes Prevention Program Outcomes Study.
Hazuda HP, Pan Q, Florez H, Luchsinger JA, Crandall JP, Venditti EM, Golden SH, Kriska AM, Bray GA. Hazuda HP, et al. Among authors: luchsinger ja. J Gerontol A Biol Sci Med Sci. 2021 Apr 30;76(5):929-936. doi: 10.1093/gerona/glaa295. J Gerontol A Biol Sci Med Sci. 2021. PMID: 33428709 Free PMC article. Clinical Trial.
We sought to examine whether the odds of frailty among individuals at high risk of diabetes randomized to treatment with intensive lifestyle (ILS), metformin, or placebo differed after long-term follow-up. METHOD: The sample comprised participants in the Diabetes Preventio …
We sought to examine whether the odds of frailty among individuals at high risk of diabetes randomized to treatment with intensive lifestyle …
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