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Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β.
Bohrmann B, Baumann K, Benz J, Gerber F, Huber W, Knoflach F, Messer J, Oroszlan K, Rauchenberger R, Richter WF, Rothe C, Urban M, Bardroff M, Winter M, Nordstedt C, Loetscher H. Bohrmann B, et al. Among authors: loetscher h. J Alzheimers Dis. 2012;28(1):49-69. doi: 10.3233/JAD-2011-110977. J Alzheimers Dis. 2012. PMID: 21955818
In functional assays gantenerumab induced cellular phagocytosis of human amyloid-beta deposits in AD brain slices when co-cultured with primary human macrophages and neutralized oligomeric Abeta42-mediated inhibitory effects on long-term potentiation in rat brain. In APP75 …
In functional assays gantenerumab induced cellular phagocytosis of human amyloid-beta deposits in AD brain slices when co-cultured with prim …
Evolution of collagen arthritis in mice is arrested by treatment with anti-tumour necrosis factor (TNF) antibody or a recombinant soluble TNF receptor.
Piguet PF, Grau GE, Vesin C, Loetscher H, Gentz R, Lesslauer W. Piguet PF, et al. Among authors: loetscher h. Immunology. 1992 Dec;77(4):510-4. Immunology. 1992. PMID: 1337334 Free PMC article.
A soluble form of the human recombinant TNF receptor type-beta (rsTNFR-beta), continuously infused at a rate of 20 micrograms/day during the second and third week after immunization, also had a long-term protective effect. Anti-TNF antibody had no effect upon the productio …
A soluble form of the human recombinant TNF receptor type-beta (rsTNFR-beta), continuously infused at a rate of 20 micrograms/day during the …