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Fish oil supplemented for 9 months does not improve glycaemic control or insulin sensitivity in subjects with impaired glucose regulation: a parallel randomised controlled trial.
Clark LF, Thivierge MC, Kidd CA, McGeoch SC, Abraham P, Pearson DW, Horgan GW, Holtrop G, Thies F, Lobley GE. Clark LF, et al. Among authors: lobley ge. Br J Nutr. 2016 Jan 14;115(1):75-86. doi: 10.1017/S0007114515004274. Epub 2015 Nov 5. Br J Nutr. 2016. PMID: 26537735 Clinical Trial.
In an associated pilot study (n 4, three completed), although n-3 PUFA in erythrocyte membranes increased to >14% with the FO supplement, the enrichment in muscle membranes remained lower (8%; P<0.001). In conclusion, long-term supplementation with FO, at amounts nea …
In an associated pilot study (n 4, three completed), although n-3 PUFA in erythrocyte membranes increased to >14% with the FO supplement, …
Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure.
Siervo M, Faber P, Lara J, Gibney ER, Milne E, Ritz P, Lobley GE, Elia M, Stubbs RJ, Johnstone AM. Siervo M, et al. Among authors: lobley ge. Metabolism. 2015 Aug;64(8):896-904. doi: 10.1016/j.metabol.2015.03.011. Epub 2015 Apr 8. Metabolism. 2015. PMID: 25908563
Metabolic adaptation for resting EE was greater in the LCD (-0.4 MJ/day, -5.3%) compared to the VLCD (-0.1 MJ/day, -1.4%) group. Resting EE did not decrease after short-term fasting and no evidence of adaptive thermogenesis (+0.4 MJ/day) was found after 5% WL. ...
Metabolic adaptation for resting EE was greater in the LCD (-0.4 MJ/day, -5.3%) compared to the VLCD (-0.1 MJ/day, -1.4%) group. Resting EE …
High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health.
Russell WR, Gratz SW, Duncan SH, Holtrop G, Ince J, Scobbie L, Duncan G, Johnstone AM, Lobley GE, Wallace RJ, Duthie GG, Flint HJ. Russell WR, et al. Among authors: lobley ge. Am J Clin Nutr. 2011 May;93(5):1062-72. doi: 10.3945/ajcn.110.002188. Epub 2011 Mar 9. Am J Clin Nutr. 2011. PMID: 21389180 Free article. Clinical Trial.
OBJECTIVE: We designed this study to assess the effect of diets with reduced carbohydrate and increased protein contents on metabolites considered to influence long-term colonic health, in particular the risk of colorectal disease. ...CONCLUSIONS: After 4 wk, weight-loss d …
OBJECTIVE: We designed this study to assess the effect of diets with reduced carbohydrate and increased protein contents on metabolites cons …
Protein synthesis and antioxidant capacity in aging mice: effects of long-term voluntary exercise.
Vaanholt LM, Speakman JR, Garland T Jr, Lobley GE, Visser GH. Vaanholt LM, et al. Among authors: lobley ge. Physiol Biochem Zool. 2008 Mar-Apr;81(2):148-57. doi: 10.1086/525289. Physiol Biochem Zool. 2008. PMID: 18199000 Free article.
Alternatively, the elevated energy expenditure may reflect the energetic cost of elevated protection, consistent with the disposable-soma hypothesis and with other studies showing positive links between energy expenditure and life span. Long-term elevations in voluntary ex …
Alternatively, the elevated energy expenditure may reflect the energetic cost of elevated protection, consistent with the disposable-soma hy …
Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum.
Johnstone AM, Horgan GW, Murison SD, Bremner DM, Lobley GE. Johnstone AM, et al. Among authors: lobley ge. Am J Clin Nutr. 2008 Jan;87(1):44-55. doi: 10.1093/ajcn/87.1.44. Am J Clin Nutr. 2008. PMID: 18175736 Free article. Clinical Trial.
The LC diet induced ketosis with mean 3-hydroxybutyrate concentrations of 1.52 mmol/L in plasma (P=0.036 from baseline; SED: 0.62) and 2.99 mmol/L in urine (P<0.001 from baseline; SED: 0.36). CONCLUSION: In the short term, high-protein, low-carbohydrate ketogenic diets …
The LC diet induced ketosis with mean 3-hydroxybutyrate concentrations of 1.52 mmol/L in plasma (P=0.036 from baseline; SED: 0.62) and 2.99 …
Dietary macronutrient content alters cortisol metabolism independently of body weight changes in obese men.
Stimson RH, Johnstone AM, Homer NZ, Wake DJ, Morton NM, Andrew R, Lobley GE, Walker BR. Stimson RH, et al. Among authors: lobley ge. J Clin Endocrinol Metab. 2007 Nov;92(11):4480-4. doi: 10.1210/jc.2007-0692. Epub 2007 Sep 4. J Clin Endocrinol Metab. 2007. PMID: 17785367 Clinical Trial.
Both dietary fat and insulin alter glucocorticoid metabolism in rodents and, acutely, in humans. However, whether longer-term differences in dietary macronutrients affect cortisol metabolism in humans and contribute to the tissue-specific dysregulation of cortisol metaboli …
Both dietary fat and insulin alter glucocorticoid metabolism in rodents and, acutely, in humans. However, whether longer-term differe …
Liver nitrogen movements during short-term infusion of high levels of ammonia into the mesenteric vein of sheep.
Milano GD, Lobley GE. Milano GD, et al. Among authors: lobley ge. Br J Nutr. 2001 Oct;86(4):507-13. doi: 10.1079/bjn2001426. Br J Nutr. 2001. PMID: 11591238
The study showed that conversion of excess NH3 to urea during a short-term hepatic NH3 overload required no additional contribution of AA-N to ureagenesis; essential AA and branched-chain AA supply to non-splanchnic tissues was, however, temporarily decreased....
The study showed that conversion of excess NH3 to urea during a short-term hepatic NH3 overload required no additional contribution o …
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