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Oligodendrocytes in human induced pluripotent stem cell-derived cortical grafts remyelinate adult rat and human cortical neurons.
Martinez-Curiel R, Jansson L, Tsupykov O, Avaliani N, Aretio-Medina C, Hidalgo I, Monni E, Bengzon J, Skibo G, Lindvall O, Kokaia Z, Palma-Tortosa S. Martinez-Curiel R, et al. Among authors: lindvall o. Stem Cell Reports. 2023 Aug 8;18(8):1643-1656. doi: 10.1016/j.stemcr.2023.04.010. Epub 2023 May 25. Stem Cell Reports. 2023. PMID: 37236198 Free PMC article.
Neuronal loss and axonal demyelination underlie long-term functional impairments in patients affected by brain disorders such as ischemic stroke. ...Here, we demonstrate the in vitro and in vivo production of myelinating oligodendrocytes from a human induced pluripotent st …
Neuronal loss and axonal demyelination underlie long-term functional impairments in patients affected by brain disorders such as isch …
Poly(ester amide) microspheres are efficient vehicles for long-term intracerebral growth factor delivery and improve functional recovery after stroke.
Memanishvili T, Monni E, Tatarishivili J, Lindvall O, Tsiskaridze A, Kokaia Z, Tornero D. Memanishvili T, et al. Among authors: lindvall o. Biomed Mater. 2020 Nov 21;15(6):065020. doi: 10.1088/1748-605X/aba4f6. Biomed Mater. 2020. PMID: 32650328
Loaded MS provided sustained release of VEGF in vitro and, after injection, biologically active VEGF was released long-term, as evidenced by high VEGF immunoreactivity, increased VEGF tissue levels, and higher vessel density and more NG2+ cells in injured hemisphere of ani …
Loaded MS provided sustained release of VEGF in vitro and, after injection, biologically active VEGF was released long-term, as evide …
Grafted human pluripotent stem cell-derived cortical neurons integrate into adult human cortical neural circuitry.
Grønning Hansen M, Laterza C, Palma-Tortosa S, Kvist G, Monni E, Tsupykov O, Tornero D, Uoshima N, Soriano J, Bengzon J, Martino G, Skibo G, Lindvall O, Kokaia Z. Grønning Hansen M, et al. Among authors: lindvall o. Stem Cells Transl Med. 2020 Nov;9(11):1365-1377. doi: 10.1002/sctm.20-0134. Epub 2020 Jun 29. Stem Cells Transl Med. 2020. PMID: 32602201 Free PMC article.
Studies in different animal models have raised the possibility that transplantation of human cortical neuronal progenitors, generated from pluripotent stem cells, might be developed into a novel therapeutic strategy for disorders affecting cerebral cortex. For example, we have sh …
Studies in different animal models have raised the possibility that transplantation of human cortical neuronal progenitors, generated from p …
Monocyte depletion early after stroke promotes neurogenesis from endogenous neural stem cells in adult brain.
Laterza C, Wattananit S, Uoshima N, Ge R, Pekny R, Tornero D, Monni E, Lindvall O, Kokaia Z. Laterza C, et al. Among authors: lindvall o. Exp Neurol. 2017 Nov;297:129-137. doi: 10.1016/j.expneurol.2017.07.012. Epub 2017 Jul 23. Exp Neurol. 2017. PMID: 28746827
Here we show that depletion of circulating monocytes, using the anti-CCR2 antibody MC-21 during the first week after stroke, enhances striatal neurogenesis at one week post-insult, most likely by increasing short-term survival of the newly formed neuroblasts in the SVZ and …
Here we show that depletion of circulating monocytes, using the anti-CCR2 antibody MC-21 during the first week after stroke, enhances striat …
Stroke alters behavior of human skin-derived neural progenitors after transplantation adjacent to neurogenic area in rat brain.
de la Rosa-Prieto C, Laterza C, Gonzalez-Ramos A, Wattananit S, Ge R, Lindvall O, Tornero D, Kokaia Z. de la Rosa-Prieto C, et al. Among authors: lindvall o. Stem Cell Res Ther. 2017 Mar 9;8(1):59. doi: 10.1186/s13287-017-0513-6. Stem Cell Res Ther. 2017. PMID: 28279192 Free PMC article.
METHODS: Here we have assessed the influence of the stroke-induced injury on grafts of human skin iPSCs-derived long-term neuroepithelial-like stem cells using transplantation into the rostral migratory stream (RMS), adjacent to the neurogenic subventricular zone, in adult …
METHODS: Here we have assessed the influence of the stroke-induced injury on grafts of human skin iPSCs-derived long-term neuroepithe …
Extensive graft-derived dopaminergic innervation is maintained 24 years after transplantation in the degenerating parkinsonian brain.
Li W, Englund E, Widner H, Mattsson B, van Westen D, Lätt J, Rehncrona S, Brundin P, Björklund A, Lindvall O, Li JY. Li W, et al. Among authors: lindvall o. Proc Natl Acad Sci U S A. 2016 Jun 7;113(23):6544-9. doi: 10.1073/pnas.1605245113. Epub 2016 May 2. Proc Natl Acad Sci U S A. 2016. PMID: 27140603 Free PMC article.
Clinical trials using cells derived from embryonic ventral mesencephalon have shown that transplanted dopaminergic neurons can survive and function in the long term, as demonstrated by in vivo brain imaging using (18)F-fluorodopa and (11)C-raclopride positron emission tomo …
Clinical trials using cells derived from embryonic ventral mesencephalon have shown that transplanted dopaminergic neurons can survive and f …
Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice.
Wattananit S, Tornero D, Graubardt N, Memanishvili T, Monni E, Tatarishvili J, Miskinyte G, Ge R, Ahlenius H, Lindvall O, Schwartz M, Kokaia Z. Wattananit S, et al. Among authors: lindvall o. J Neurosci. 2016 Apr 13;36(15):4182-95. doi: 10.1523/JNEUROSCI.4317-15.2016. J Neurosci. 2016. PMID: 27076418 Free PMC article.
Monocyte-derived macrophages (MDMs) exhibit a high degree of functional plasticity. Here, we determined the role of MDMs in long-term spontaneous functional recovery after middle cerebral artery occlusion in mice. ...We show here, for the first time, that MDMs recruited to …
Monocyte-derived macrophages (MDMs) exhibit a high degree of functional plasticity. Here, we determined the role of MDMs in long-term …
Human induced pluripotent stem cells improve recovery in stroke-injured aged rats.
Tatarishvili J, Oki K, Monni E, Koch P, Memanishvili T, Buga AM, Verma V, Popa-Wagner A, Brüstle O, Lindvall O, Kokaia Z. Tatarishvili J, et al. Among authors: lindvall o. Restor Neurol Neurosci. 2014;32(4):547-58. doi: 10.3233/RNN-140404. Restor Neurol Neurosci. 2014. PMID: 24916776
After 48 h, animals were transplanted intracortically with human iPSC-derived long-term neuroepithelial-like stem (hiPSC-lt-NES) cells. Controls were subjected to stroke and were vehicle-injected. ...
After 48 h, animals were transplanted intracortically with human iPSC-derived long-term neuroepithelial-like stem (hiPSC-lt-NES) cell …
Long-term clinical outcome of fetal cell transplantation for Parkinson disease: two case reports.
Kefalopoulou Z, Politis M, Piccini P, Mencacci N, Bhatia K, Jahanshahi M, Widner H, Rehncrona S, Brundin P, Björklund A, Lindvall O, Limousin P, Quinn N, Foltynie T. Kefalopoulou Z, et al. Among authors: lindvall o. JAMA Neurol. 2014 Jan;71(1):83-7. doi: 10.1001/jamaneurol.2013.4749. JAMA Neurol. 2014. PMID: 24217017 Free PMC article.
IMPORTANCE: Recent advances in stem cell technologies have rekindled an interest in the use of cell replacement strategies for patients with Parkinson disease. This study reports the very long-term clinical outcomes of fetal cell transplantation in 2 patients with Parkinso …
IMPORTANCE: Recent advances in stem cell technologies have rekindled an interest in the use of cell replacement strategies for patients with …
56 results