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β-Arrestin2 mediates progression of murine primary myelofibrosis.
Rein LA, Wisler JW, Kim J, Theriot B, Huang L, Price T, Yang H, Chen M, Chen W, Sipkins D, Fedoriw Y, Walker JK, Premont RT, Lefkowitz RJ. Rein LA, et al. Among authors: lefkowitz rj. JCI Insight. 2017 Dec 21;2(24):e98094. doi: 10.1172/jci.insight.98094. JCI Insight. 2017. PMID: 29263312 Free PMC article.
Although transplanted betaarr2-/- cells homed properly to marrow, they did not repopulate long-term due to increased apoptosis and decreased self-renewal of betaarr2-/- cells. ...
Although transplanted betaarr2-/- cells homed properly to marrow, they did not repopulate long-term due to increased apoptosis and de …
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ. Hara MR, et al. Among authors: lefkowitz rj. Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368. Nature. 2011. PMID: 21857681 Free PMC article.
The stress response is generally transient because its accompanying effects (for example, immunosuppression, growth inhibition and enhanced catabolism) can be harmful in the long term. When chronic, the stress response can be associated with disease symptoms such as peptic …
The stress response is generally transient because its accompanying effects (for example, immunosuppression, growth inhibition and enhanced …
Beta-Arrestins: new roles in regulating heptahelical receptors' functions.
McDonald PH, Lefkowitz RJ. McDonald PH, et al. Among authors: lefkowitz rj. Cell Signal. 2001 Oct;13(10):683-9. doi: 10.1016/s0898-6568(01)00203-0. Cell Signal. 2001. PMID: 11602178 Review.
More recently, betaArrestins have been shown to act as molecular scaffolds that coordinate the assembly of certain MAP kinase complexes that lead to the stimulation of either ERK1/2 or JNK3. Finally, long-term accumulation of arrestin-rhodopsin complexes, in photoreceptor …
More recently, betaArrestins have been shown to act as molecular scaffolds that coordinate the assembly of certain MAP kinase complexes that …
Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.
Freeman K, Lerman I, Kranias EG, Bohlmeyer T, Bristow MR, Lefkowitz RJ, Iaccarino G, Koch WJ, Leinwand LA. Freeman K, et al. Among authors: lefkowitz rj. J Clin Invest. 2001 Apr;107(8):967-74. doi: 10.1172/JCI12083. J Clin Invest. 2001. PMID: 11306600 Free PMC article.
The medical treatment of chronic heart failure has undergone a dramatic transition in the past decade. Short-term approaches for altering hemodynamics have given way to long-term, reparative strategies, including beta-adrenergic receptor (betaAR) blockade. ...
The medical treatment of chronic heart failure has undergone a dramatic transition in the past decade. Short-term approaches for alte …
Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade.
Iaccarino G, Tomhave ED, Lefkowitz RJ, Koch WJ. Iaccarino G, et al. Among authors: lefkowitz rj. Circulation. 1998 Oct 27;98(17):1783-9. doi: 10.1161/01.cir.98.17.1783. Circulation. 1998. PMID: 9788834
We have chronically treated mice with drugs that either activate or antagonize betaARs to study the dynamic relationship between betaAR activation and myocardial levels of betaARK1. METHODS AND RESULTS: Long-term in vivo stimulation of betaARs results in the impairment of …
We have chronically treated mice with drugs that either activate or antagonize betaARs to study the dynamic relationship between betaAR acti …
G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension.
Ishizaka N, Alexander RW, Laursen JB, Kai H, Fukui T, Oppermann M, Lefkowitz RJ, Lyons PR, Griendling KK. Ishizaka N, et al. Among authors: lefkowitz rj. J Biol Chem. 1997 Dec 19;272(51):32482-8. doi: 10.1074/jbc.272.51.32482. J Biol Chem. 1997. PMID: 9405459 Free article.
Hormone- and hemodynamic stress-induced GRK5 regulation may provide a novel molecular basis for long-term regulation of agonist sensitivity of vascular cells....
Hormone- and hemodynamic stress-induced GRK5 regulation may provide a novel molecular basis for long-term regulation of agonist sensi …
Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine.
Korzick DH, Xiao RP, Ziman BD, Koch WJ, Lefkowitz RJ, Lakatta EG. Korzick DH, et al. Among authors: lefkowitz rj. Am J Physiol. 1997 Jan;272(1 Pt 2):H590-6. doi: 10.1152/ajpheart.1997.272.1.H590. Am J Physiol. 1997. PMID: 9038983
These data suggest that 1) in the absence of circulating catecholamines or basal sympathetic tone, beta ARK1 actions in single myocytes are minimal, and 2) substantial functional beta ARK1 modulation of beta 1-AR signaling occurs in cardiac myocytes even during short-term …
These data suggest that 1) in the absence of circulating catecholamines or basal sympathetic tone, beta ARK1 actions in single myocytes are …
Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C.
Pei G, Kieffer BL, Lefkowitz RJ, Freedman NJ. Pei G, et al. Among authors: lefkowitz rj. Mol Pharmacol. 1995 Aug;48(2):173-7. Mol Pharmacol. 1995. PMID: 7651349
Concordantly, beta ARK1-K220R overexpression reduced agonist-dependent delta OR desensitization, whereas beta ARK1 overexpression enhanced this densensitization. We conclude that short term desensitization of the delta OR involves phosphorylation of the receptor by one or …
Concordantly, beta ARK1-K220R overexpression reduced agonist-dependent delta OR desensitization, whereas beta ARK1 overexpression enhanced t …
Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.
Liggett SB, Freedman NJ, Schwinn DA, Lefkowitz RJ. Liggett SB, et al. Among authors: lefkowitz rj. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3665-9. doi: 10.1073/pnas.90.8.3665. Proc Natl Acad Sci U S A. 1993. PMID: 8386380 Free PMC article.
We therefore tested the idea that the agonist-induced regulatory properties of the two receptors might differ by expressing both subtypes in CHW cells and exposing them to the agonist isoproterenol. The beta 3AR did not display short-term agonist-promoted functional desens …
We therefore tested the idea that the agonist-induced regulatory properties of the two receptors might differ by expressing both subtypes in …
14 results