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Low cost, high temporal resolution optical fiber-based γ-photon sensor for real-time pre-clinical evaluation of cancer-targeting radiopharmaceuticals.
Lall R, Lee K, Chopra S, Kandala A, Evans M, Seo Y, Niknejad A, Anwar M. Lall R, et al. Biosens Bioelectron. 2024 Mar 1;247:115956. doi: 10.1016/j.bios.2023.115956. Epub 2023 Dec 21. Biosens Bioelectron. 2024. PMID: 38145595 Free article.
Recognizing the significant heterogeneity in biodistribution of RPTs among even genetically identical animal models, this approach offers long-term monitoring of the same in vivo organism without euthanasia in contrast to ex vivo tissue dosimetry, while providing high temp …
Recognizing the significant heterogeneity in biodistribution of RPTs among even genetically identical animal models, this approach offers lo …
Economic Evaluation of Using Daily Prednisolone versus Placebo at the Time of an Upper Respiratory Tract Infection for the Management of Children with Steroid-Sensitive Nephrotic Syndrome: A Model-Based Analysis.
Afentou N, Frew E, Mehta S, Ives NJ, Woolley RL, Brettell EA, Khan AR, Milford DV, Bockenhauer D, Saleem MA, Hall AS, Koziell A, Maxwell H, Hegde S, Finlay E, Gilbert RD, Jones C, McKeever K, Cook W, Webb NJA, Christian MT; PREDNOS Collaborative Group, NIHR Medicines for Children Research Network Nephrology Clinical Studies Group. Afentou N, et al. Pharmacoecon Open. 2022 Jul;6(4):605-617. doi: 10.1007/s41669-022-00334-6. Epub 2022 Jun 22. Pharmacoecon Open. 2022. PMID: 35733076 Free PMC article.
BACKGROUND: Childhood steroid-sensitive nephrotic syndrome is a frequently relapsing disease with significant short- and long-term complications, leading to high healthcare costs and reduced quality of life for patients. ...RESULTS: The base-case results showed that admini …
BACKGROUND: Childhood steroid-sensitive nephrotic syndrome is a frequently relapsing disease with significant short- and long-term co …
Sugar or salt ("SOS"): A protocol for a UK multicentre randomised trial of mannitol and hypertonic saline in severe traumatic brain injury and intracranial hypertension.
Rowland MJ, Veenith T, Scomparin C, Wilson MH, Hutchinson PJ, Kolias AG, Lall R, Regan S, Mason J, Andrews P, Horner D, Naisbitt J, Devrell A, Malins A, Dark P, McAuley DF, Perkins GD. Rowland MJ, et al. Among authors: lall r. J Intensive Care Soc. 2022 May;23(2):222-232. doi: 10.1177/1751143720901690. Epub 2020 Feb 25. J Intensive Care Soc. 2022. PMID: 35615234 Free PMC article.
Results will inform current clinical practice in the routine use of hyperosmolar therapy as well as assess the impact of potential side effects. Pre-planned longer term clinical and cost effectiveness analyses will further inform the use of these treatments....
Results will inform current clinical practice in the routine use of hyperosmolar therapy as well as assess the impact of potential side effe …
Development and testing of an opioid tapering self-management intervention for chronic pain: I-WOTCH.
Sandhu HK, Shaw J, Carnes D, Furlan AD, Tysall C, Adjei H, Muthiah C, Noyes J, Tang NKY, Taylor SJ, Underwood M, Willis A, Eldabe S; I-WOTCH Team. Sandhu HK, et al. BMJ Open. 2022 Mar 16;12(3):e053725. doi: 10.1136/bmjopen-2021-053725. BMJ Open. 2022. PMID: 35296478 Free PMC article. Clinical Trial.
INTERVENTIONS AND RESULTS: Receiving information on the impact of long-term opioid use, and potential adverse effects were highlighted as important facilitators in making the decision to reduce opioids. ...
INTERVENTIONS AND RESULTS: Receiving information on the impact of long-term opioid use, and potential adverse effects were highlighte …
Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19: The RECOVERY-RS Randomized Clinical Trial.
Perkins GD, Ji C, Connolly BA, Couper K, Lall R, Baillie JK, Bradley JM, Dark P, Dave C, De Soyza A, Dennis AV, Devrell A, Fairbairn S, Ghani H, Gorman EA, Green CA, Hart N, Hee SW, Kimbley Z, Madathil S, McGowan N, Messer B, Naisbitt J, Norman C, Parekh D, Parkin EM, Patel J, Regan SE, Ross C, Rostron AJ, Saim M, Simonds AK, Skilton E, Stallard N, Steiner M, Vancheeswaran R, Yeung J, McAuley DF; RECOVERY-RS Collaborators. Perkins GD, et al. Among authors: lall r. JAMA. 2022 Feb 8;327(6):546-558. doi: 10.1001/jama.2022.0028. JAMA. 2022. PMID: 35072713 Free PMC article. Clinical Trial.
Fall prevention interventions in primary care to reduce fractures and falls in people aged 70 years and over: the PreFIT three-arm cluster RCT.
Bruce J, Hossain A, Lall R, Withers EJ, Finnegan S, Underwood M, Ji C, Bojke C, Longo R, Hulme C, Hennings S, Sheridan R, Westacott K, Ralhan S, Martin F, Davison J, Shaw F, Skelton DA, Treml J, Willett K, Lamb SE. Bruce J, et al. Among authors: lall r. Health Technol Assess. 2021 May;25(34):1-114. doi: 10.3310/hta25340. Health Technol Assess. 2021. PMID: 34075875 Free PMC article. Clinical Trial.
CONCLUSIONS: Screen-and-treat falls prevention strategies in primary care did not reduce fractures. Exercise resulted in a short-term reduction in falls and was cost-effective. FUTURE WORK: Exercise is the most promising intervention for primary care. ...We found no differ …
CONCLUSIONS: Screen-and-treat falls prevention strategies in primary care did not reduce fractures. Exercise resulted in a short-term …
Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT.
Perkins GD, Ji C, Achana F, Black JJ, Charlton K, Crawford J, de Paeztron A, Deakin C, Docherty M, Finn J, Fothergill RT, Gates S, Gunson I, Han K, Hennings S, Horton J, Khan K, Lamb S, Long J, Miller J, Moore F, Nolan J, O'Shea L, Petrou S, Pocock H, Quinn T, Rees N, Regan S, Rosser A, Scomparin C, Slowther A, Lall R. Perkins GD, et al. Among authors: lall r. Health Technol Assess. 2021 Apr;25(25):1-166. doi: 10.3310/hta25250. Health Technol Assess. 2021. PMID: 33861194 Free PMC article. Clinical Trial.
BACKGROUND: Adrenaline has been used as a treatment for cardiac arrest for many years, despite uncertainty about its effects on long-term outcomes and concerns that it may cause worse neurological outcomes. ...In a community survey, 95% of people who responded thought that …
BACKGROUND: Adrenaline has been used as a treatment for cardiac arrest for many years, despite uncertainty about its effects on long-term …
Long term outcomes of participants in the PARAMEDIC2 randomised trial of adrenaline in out-of-hospital cardiac arrest.
Haywood KL, Ji C, Quinn T, Nolan JP, Deakin CD, Scomparin C, Lall R, Gates S, Long J, Regan S, Fothergill RT, Pocock H, Rees N, O'Shea L, Perkins GD. Haywood KL, et al. Among authors: lall r. Resuscitation. 2021 Mar;160:84-93. doi: 10.1016/j.resuscitation.2021.01.019. Epub 2021 Jan 30. Resuscitation. 2021. PMID: 33524488 Clinical Trial.
AIMS: We recently reported early outcomes in patients enrolled in a randomised trial of adrenaline in out-of-hospital cardiac arrest: the PARAMEDIC2 (Prehospital Assessment of the Role of Adrenaline: Measuring the Effectiveness of Drug Administration in Cardiac Arrest) trial. The …
AIMS: We recently reported early outcomes in patients enrolled in a randomised trial of adrenaline in out-of-hospital cardiac arrest: the PA …
Protocol for an economic analysis of the randomised controlled trial of Improving the Well-being of people with Opioid Treated CHronic pain: I-WOTCH Study.
Manchira Krishnan S, Gc VS, Sandhu HK, Underwood M, Eldabe S, Manca A, Iglesias Urrutia CP; I-WOTCH team. Manchira Krishnan S, et al. BMJ Open. 2020 Nov 20;10(11):e037243. doi: 10.1136/bmjopen-2020-037243. BMJ Open. 2020. PMID: 33444175 Free PMC article.
A within-trial cost-consequences analysis and a model-based long-term cost-effectiveness analysis will be conducted from the National Health Service and Personal Social Service perspective in England. The former will quantify key parameters to populate a Markov model desig …
A within-trial cost-consequences analysis and a model-based long-term cost-effectiveness analysis will be conducted from the National …
L5 Fracture Dislocation Secondary to Cold Abscess Treated by Posterior Corpectomy With Expandable Cage Placement.
McFarland JR 3rd, Branch D, Gonzalez A, Campbell G, Lall RR. McFarland JR 3rd, et al. Among authors: lall rr. Cureus. 2020 Jun 22;12(6):e8756. doi: 10.7759/cureus.8756. Cureus. 2020. PMID: 32714694 Free PMC article.
In cases with significant instability or neurological compromise, a common treatment approach is vertebral corpectomy with interbody cage followed by long-term antibiotics. The following case describes a patient with a three-month history of progressively worsening lower b …
In cases with significant instability or neurological compromise, a common treatment approach is vertebral corpectomy with interbody cage fo …
33 results