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The role of surgical management for prolactin-secreting tumors in the era of dopaminergic agonists: An international multicenter report.
Findlay MC, Sabahi M, Azab M, Drexler R, Rotermund R, Ricklefs FL, Flitsch J, Smith TR, Kilgallon JL, Honegger J, Nasi-Kordhishti I, Gardner PA, Gersey ZC, Abdallah HM, Jane JA, Knappe UJ, Uksul N, Schroder HWS, Eördögh M, Losa M, Mortini P, Gerlach R, Antunes ACM, Couldwell WT, Budohoski KP, Rennert RC, Karsy M. Findlay MC, et al. Among authors: knappe uj. Clin Neurol Neurosurg. 2024 Jan;236:108079. doi: 10.1016/j.clineuro.2023.108079. Epub 2023 Dec 10. Clin Neurol Neurosurg. 2024. PMID: 38091700
These data can serve as a benchmark to compare with DA therapy and other surgical series. Further study and longer term outcomes could provide insight into how patients benefit from surgical treatment....
These data can serve as a benchmark to compare with DA therapy and other surgical series. Further study and longer term outcomes coul …
Predictive Value of Early Postoperative Course of Serum Cortisol After Transsphenoidal Surgery for Cushing's Disease.
Meier M, Alomari A, Feldkamp J, Mann WA, Santen R, Ewald N, Knappe UJ. Meier M, et al. Among authors: knappe uj. Exp Clin Endocrinol Diabetes. 2022 Nov;130(11):704-713. doi: 10.1055/a-1909-1639. Epub 2022 Sep 9. Exp Clin Endocrinol Diabetes. 2022. PMID: 36084942 Free article.
OBJECTIVE: To identify early available predictors for the long-term outcome of patients after transsphenoidal surgery (TSS) in the management of Cushing's disease. ...Of these, 8 patients (10%) developed recurrence of hypercortisolism. Compared to patients with persisting …
OBJECTIVE: To identify early available predictors for the long-term outcome of patients after transsphenoidal surgery (TSS) in the ma …
First German Guideline on Diagnostics and Therapy of Clinically Non-Functioning Pituitary Tumors.
Deutschbein T, Jaursch-Hancke C, Knappe UJ, Saeger W, Flitsch J, Bojunga J, Buchfelder M, Ditzen B, Gerlach R, Gertzen E, Honegger J, Horstmann GA, Koch A, Kreitschmann-Andermahr I, Kunz M, Lagrèze WA, Nicolay NH, Paulus W, Reincke M, Schmidt MA, Weber MM, Wilhelm H, Fassnacht M. Deutschbein T, et al. Among authors: knappe uj. Exp Clin Endocrinol Diabetes. 2021 Mar;129(3):250-264. doi: 10.1055/a-1373-4087. Epub 2021 Mar 9. Exp Clin Endocrinol Diabetes. 2021. PMID: 33690872
Irrespective of the therapeutic approach applied, patients require long-term follow-up. Patient with larger pituitary tumors or former surgery/radiotherapy should be regularly counseled regarding potential symptoms of hormonal deficiency states....
Irrespective of the therapeutic approach applied, patients require long-term follow-up. Patient with larger pituitary tumors or forme …
Facet Joint Replacement: Intermediate- and Long-Term Outcome in a Large Case Series.
Knappe UJ, Reinecke D, Flörke M, Horn P, Schönmayr R. Knappe UJ, et al. J Neurol Surg A Cent Eur Neurosurg. 2021 Jan;82(1):34-42. doi: 10.1055/s-0040-1716534. Epub 2020 Dec 5. J Neurol Surg A Cent Eur Neurosurg. 2021. PMID: 33278826
BACKGROUND: The long-term outcome of facet joint replacement (FJR) still is to be proven. ...Explantation of FJR and subsequent fusion had to be performed in four cases (15.4%). CONCLUSIONS: In selected cases, long-term results of FJR show good outcome concerning pa …
BACKGROUND: The long-term outcome of facet joint replacement (FJR) still is to be proven. ...Explantation of FJR and subsequent fusio …
Efficacy of Temozolomide Therapy in Patients With Aggressive Pituitary Adenomas and Carcinomas-A German Survey.
Elbelt U, Schlaffer SM, Buchfelder M, Knappe UJ, Vila G, Micko A, Deutschbein T, Unger N, Lammert A, Topuzoglu-Müller T, Bojunga J, Droste M, Johanssen S, Kolenda H, Ritzel K, Buslei R, Strasburger CJ, Petersenn S, Honegger J. Elbelt U, et al. Among authors: knappe uj. J Clin Endocrinol Metab. 2020 Mar 1;105(3):dgz211. doi: 10.1210/clinem/dgz211. J Clin Endocrinol Metab. 2020. PMID: 31746334
OBJECTIVE: We therefore aimed to report on clinical characteristics leading to initiation of TMZ therapy and to add evidence on TMZ long-term effectiveness. DESIGN AND SUBJECTS: Retrospective survey on TMZ treatment in patients with APTs or PCs. ...CONCLUSION: We performed …
OBJECTIVE: We therefore aimed to report on clinical characteristics leading to initiation of TMZ therapy and to add evidence on TMZ long- …
The use of postoperative ACTH levels as a marker for successful transsphenoidal microsurgery in Cushing's disease.
Flitsch J, Knappe UJ, Lüdecke DK. Flitsch J, et al. Among authors: knappe uj. Zentralbl Neurochir. 2003;64(1):6-11. doi: 10.1055/s-2003-37145. Zentralbl Neurochir. 2003. PMID: 12582940 Clinical Trial.
We investigated whether the early postoperative ACTH concentration is a reliable marker for the initial surgical outcome as well as the long-term remission. METHODS: In a prospective study, 147 patients undergoing primary transsphenoidal microsurgery for Cushing's disease …
We investigated whether the early postoperative ACTH concentration is a reliable marker for the initial surgical outcome as well as the long …
Correlates of long-term hypocortisolism after transsphenoidal microsurgery for Cushing's disease.
Flitsch J, Lüdecke DK, Knappe UJ, Saeger W. Flitsch J, et al. Among authors: knappe uj. Exp Clin Endocrinol Diabetes. 1999;107(3):183-9. doi: 10.1055/s-0029-1212095. Exp Clin Endocrinol Diabetes. 1999. PMID: 10376443
Extensive pituitary exploration, medial localization of the tumor, and a higher age were associated with increased risk for isolated secondary long-term hypocortisolism. The histological examination of paraadenomateous tissue identified a significantly larger amount of Cro …
Extensive pituitary exploration, medial localization of the tumor, and a higher age were associated with increased risk for isolated seconda …
Treatment and long-term outcome of pineal nongerminomatous germ cell tumors.
Knappe UJ, Bentele K, Horstmann M, Herrmann HD. Knappe UJ, et al. Pediatr Neurosurg. 1998 May;28(5):241-5. doi: 10.1159/000028658. Pediatr Neurosurg. 1998. PMID: 9732256
In 1994 we reported on a small series of 3 children with malignant, marker-positive pineal nongerminomatous germ cell tumors treated with a 'sandwich' protocol. Here, we report on the long-term survival of these children. Preoperative chemotherapy consisted of two courses …
In 1994 we reported on a small series of 3 children with malignant, marker-positive pineal nongerminomatous germ cell tumors treated with a …
Pituitary surgery in elderly patients with acromegaly.
Puchner MJ, Knappe UJ, Lüdecke DK. Puchner MJ, et al. Among authors: knappe uj. Neurosurgery. 1995 Apr;36(4):677-83; discussion 683-4. doi: 10.1227/00006123-199504000-00006. Neurosurgery. 1995. PMID: 7596496
Postoperative basal GH-plasma levels were normal (< 4.5 micrograms/L) in all patients. None of the 13 patients who participated in long-term follow-up examinations (mean, 4.2 yr) revealed signs of definite tumor recurrence. ...
Postoperative basal GH-plasma levels were normal (< 4.5 micrograms/L) in all patients. None of the 13 patients who participated in long- …