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Association Between β-Amyloid Accumulation and Incident Dementia in Individuals 80 Years or Older Without Dementia.
Lopez OL, Villemagne VL, Chang YF, Cohen AD, Klunk WE, Mathis CA, Pascoal T, Ikonomovic MD, Rowe C, Dore V, Snitz BE, Lopresti BJ, Kamboh MI, Aizenstein HJ, Kuller LH. Lopez OL, et al. Among authors: klunk we. Neurology. 2024 Jan 23;102(2):e207920. doi: 10.1212/WNL.0000000000207920. Epub 2023 Dec 22. Neurology. 2024. PMID: 38165336
In addition, baseline Abeta deposition was a predictor of short-term change (mean time 1.88 years). DISCUSSION: There was an accelerated Abeta accumulation in cognitively normal individuals older than 80 years. Baseline Abeta deposition was a determinant of incident dement …
In addition, baseline Abeta deposition was a predictor of short-term change (mean time 1.88 years). DISCUSSION: There was an accelera …
Predicting resistance to amyloid-beta deposition and cognitive resilience in the oldest-old.
Snitz BE, Chang Y, Tudorascu DL, Lopez OL, Lopresti BJ, DeKosky ST, Carlson MC, Cohen AD, Kamboh MI, Aizenstein HJ, Klunk WE, Kuller LH. Snitz BE, et al. Among authors: klunk we. Neurology. 2020 Aug 25;95(8):e984-e994. doi: 10.1212/WNL.0000000000010239. Epub 2020 Jul 22. Neurology. 2020. PMID: 32699143 Free PMC article.
OBJECTIVE: To explore long-term predictors of avoiding beta-amyloid (Abeta) deposition and maintaining unimpaired cognition as outcomes in the oldest old. ...
OBJECTIVE: To explore long-term predictors of avoiding beta-amyloid (Abeta) deposition and maintaining unimpaired cognition as outcom …
Amyloid deposition and brain structure as long-term predictors of MCI, dementia, and mortality.
Lopez OL, Becker JT, Chang Y, Klunk WE, Mathis C, Price J, Aizenstein HJ, Snitz B, Cohen AD, DeKosky ST, Ikonomovic M, Kamboh MI, Kuller LH. Lopez OL, et al. Among authors: klunk we. Neurology. 2018 May 22;90(21):e1920-e1928. doi: 10.1212/WNL.0000000000005549. Epub 2018 Apr 25. Neurology. 2018. PMID: 29695596 Free PMC article.
., hippocampal [HIP] volume), white matter lesions (WMLs), and beta-amyloid deposition are associated with long-term increased risk of incident dementia and mortality in 183 cognitively normal individuals and patients with mild cognitive impairment (MCI) aged 80 years and …
., hippocampal [HIP] volume), white matter lesions (WMLs), and beta-amyloid deposition are associated with long-term increased risk o …
Amyloid β Deposition and Suspected Non-Alzheimer Pathophysiology and Cognitive Decline Patterns for 12 Years in Oldest Old Participants Without Dementia.
Zhao Y, Tudorascu DL, Lopez OL, Cohen AD, Mathis CA, Aizenstein HJ, Price JC, Kuller LH, Kamboh MI, DeKosky ST, Klunk WE, Snitz BE. Zhao Y, et al. Among authors: klunk we. JAMA Neurol. 2018 Jan 1;75(1):88-96. doi: 10.1001/jamaneurol.2017.3029. JAMA Neurol. 2018. PMID: 29114732 Free PMC article.
Little is known about the distribution and clinical significance of preclinical biomarker staging in the oldest old, when most individuals without dementia are likely to have positive biomarkers. OBJECTIVE: To compare the patterns of long-term cognitive decline in multiple …
Little is known about the distribution and clinical significance of preclinical biomarker staging in the oldest old, when most individuals w …
Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer's disease: a prospective cohort study.
Yau WW, Tudorascu DL, McDade EM, Ikonomovic S, James JA, Minhas D, Mowrey W, Sheu LK, Snitz BE, Weissfeld L, Gianaros PJ, Aizenstein HJ, Price JC, Mathis CA, Lopez OL, Klunk WE. Yau WW, et al. Among authors: klunk we. Lancet Neurol. 2015 Aug;14(8):804-813. doi: 10.1016/S1474-4422(15)00135-0. Epub 2015 Jun 29. Lancet Neurol. 2015. PMID: 26139022 Free PMC article.
Despite supportive evidence from cross-sectional studies, verification with long-term within-individual data is needed. METHODS: For this prospective cohort study, carriers of autosomal dominant Alzheimer's disease mutations (aged 21 years) were recruited from across the U …
Despite supportive evidence from cross-sectional studies, verification with long-term within-individual data is needed. METHODS: For …
Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.
Lopez OL, Klunk WE, Mathis C, Coleman RL, Price J, Becker JT, Aizenstein HJ, Snitz B, Cohen A, Ikonomovic M, McDade E, DeKosky ST, Weissfeld L, Kuller LH. Lopez OL, et al. Among authors: klunk we. Neurology. 2014 Nov 11;83(20):1804-11. doi: 10.1212/WNL.0000000000000977. Epub 2014 Oct 10. Neurology. 2014. PMID: 25305156 Free PMC article. Clinical Trial.
A combination of 2 or 3 of these factors is a powerful predictor of short-term incidence of dementia....
A combination of 2 or 3 of these factors is a powerful predictor of short-term incidence of dementia....
In vivo assessment of amyloid-β deposition in nondemented very elderly subjects.
Mathis CA, Kuller LH, Klunk WE, Snitz BE, Price JC, Weissfeld LA, Rosario BL, Lopresti BJ, Saxton JA, Aizenstein HJ, McDade EM, Kamboh MI, DeKosky ST, Lopez OL. Mathis CA, et al. Among authors: klunk we. Ann Neurol. 2013 Jun;73(6):751-61. doi: 10.1002/ana.23797. Epub 2013 Apr 17. Ann Neurol. 2013. PMID: 23596051 Free PMC article. Clinical Trial.
INTERPRETATION: The data revealed a 55% prevalence of PiB positivity in nondemented subjects age >80 years and 85% PiB positivity in the APOE*4 nondemented elderly subjects. The findings also showed that long-term exposure to Gb did not affect the prevalence of cerebral …
INTERPRETATION: The data revealed a 55% prevalence of PiB positivity in nondemented subjects age >80 years and 85% PiB positivity in the …
β-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis.
Murray PS, Kirkwood CM, Gray MC, Ikonomovic MD, Paljug WR, Abrahamson EE, Henteleff RA, Hamilton RL, Kofler JK, Klunk WE, Lopez OL, Penzes P, Sweet RA. Murray PS, et al. Among authors: klunk we. Neurobiol Aging. 2012 Dec;33(12):2807-16. doi: 10.1016/j.neurobiolaging.2012.02.015. Epub 2012 Mar 17. Neurobiol Aging. 2012. PMID: 22429885 Free PMC article.
Soluble beta-amyloid induces loss of dendritic spine synapses through impairment of long-term potentiation. In contrast, the Rho guanine nucleotide exchange factor (GEF) kalirin is an essential mediator of spine maintenance and growth in cerebral cortex. ...
Soluble beta-amyloid induces loss of dendritic spine synapses through impairment of long-term potentiation. In contrast, the Rho guan …
11 results