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Biologic Therapy in Rare Eosinophil-Associated Disorders: Remaining Questions and Translational Research Opportunities.
Khoury P, Roufosse F, Kuang FL, Ackerman SJ, Akuthota P, Bochner BS, Johansson MW, Mathur SK, Ogbogu PU, Spencer LA, Wechsler ME, Zimmermann N, Klion AD; International Eosinophil Society Clinical Research Interest Group. Khoury P, et al. J Leukoc Biol. 2024 Mar 8:qiae051. doi: 10.1093/jleuko/qiae051. Online ahead of print. J Leukoc Biol. 2024. PMID: 38457125
Key topics of interest included: 1) clinical outcome measures, 2) minimally invasive biomarkers of disease activity, 3) predictors of response to biologic agents, and 4) long-term safety of eosinophil depletion. Herein, we report a summary of these discussions, presenting …
Key topics of interest included: 1) clinical outcome measures, 2) minimally invasive biomarkers of disease activity, 3) predictors of respon …
Lung-resident CD69(+)ST2(+) T(H)2 cells mediate long-term type 2 memory to inhaled antigen in mice.
Kobayashi T, Iijima K, Matsumoto K, Lama JK, Kita H. Kobayashi T, et al. Among authors: kita h. J Allergy Clin Immunol. 2023 Jul;152(1):167-181.e6. doi: 10.1016/j.jaci.2023.01.016. Epub 2023 Jan 28. J Allergy Clin Immunol. 2023. PMID: 36720287
Development of tissue-resident CD69(+)ST2(+) T(H)2 cells and long-term memory to an inhaled antigen were abrogated in mice deficient in ST2 or IL-33, but not TSLP receptor. ...
Development of tissue-resident CD69(+)ST2(+) T(H)2 cells and long-term memory to an inhaled antigen were abrogated in mice deficient …
Physiological microbial exposure transiently inhibits mouse lung ILC2 responses to allergens.
Block KE, Iijima K, Pierson MJ, Walsh DA, Tei R, Kucaba TA, Xu J, Khan MH, Staley C, Griffith TS, McSorley HJ, Kita H, Jameson SC. Block KE, et al. Among authors: kita h. Nat Immunol. 2022 Dec;23(12):1703-1713. doi: 10.1038/s41590-022-01350-8. Epub 2022 Nov 21. Nat Immunol. 2022. PMID: 36411381 Free PMC article.
These findings suggest that ILC2s respond dynamically to environmental cues and that microbial exposures do not control long-term desensitization of innate type 2 responses to allergens....
These findings suggest that ILC2s respond dynamically to environmental cues and that microbial exposures do not control long-term des …
Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: A Randomized Clinical Trial.
Nagata K, Horie T, Chohnabayashi N, Jinta T, Tsugitomi R, Shiraki A, Tokioka F, Kadowaki T, Watanabe A, Fukui M, Kitajima T, Sato S, Tsuda T, Kishimoto N, Kita H, Mori Y, Nakayama M, Takahashi K, Tsuboi T, Yoshida M, Hataji O, Fuke S, Kagajo M, Nishine H, Kobayashi H, Nakamura H, Okuda M, Tachibana S, Takata S, Osoreda H, Minami K, Nishimura T, Ishida T, Terada J, Takeuchi N, Kohashi Y, Inoue H, Nakagawa Y, Kikuchi T, Tomii K. Nagata K, et al. Among authors: kita h. Am J Respir Crit Care Med. 2022 Dec 1;206(11):1326-1335. doi: 10.1164/rccm.202201-0199OC. Am J Respir Crit Care Med. 2022. PMID: 35771533 Free PMC article. Clinical Trial.
Methods: We enrolled 104 participants (aged 40 yr) with daytime hypercapnia (Global Initiative for Chronic Obstructive Lung Disease stages 2-4) receiving long-term oxygen therapy (16 h/d for 1 mo) and randomly assigned them to high-flow nasal cannula/long-term oxyge …
Methods: We enrolled 104 participants (aged 40 yr) with daytime hypercapnia (Global Initiative for Chronic Obstructive Lung Disease stages 2 …
Encapsulated Copper-Based Phase-Change Materials for High-Temperature Heat Storage.
Zhou X, Yamashita S, Kubota M, Kita H. Zhou X, et al. Among authors: kita h. ACS Omega. 2022 Feb 2;7(6):5442-5452. doi: 10.1021/acsomega.1c06751. eCollection 2022 Feb 15. ACS Omega. 2022. PMID: 35187360 Free PMC article.
The results concluded that a Cu-(5-10%) Al capsule for high-temperature heat storage applications above 1000 C can be fabricated by a simple process, and it demonstrates excellent durability during the long-term air exposure test. The data obtained in this study can be use …
The results concluded that a Cu-(5-10%) Al capsule for high-temperature heat storage applications above 1000 C can be fabricated by a simple …
A Randomized Controlled Trial of Telemedicine for Long-Term Sleep Apnea Continuous Positive Airway Pressure Management.
Murase K, Tanizawa K, Minami T, Matsumoto T, Tachikawa R, Takahashi N, Tsuda T, Toyama Y, Ohi M, Akahoshi T, Tomita Y, Narui K, Nakamura H, Ohdaira T, Yoshimine H, Tsuboi T, Yamashiro Y, Ando S, Kasai T, Kita H, Tatsumi K, Burioka N, Tomii K, Kondoh Y, Takeyama H, Handa T, Hamada S, Oga T, Nakayama T, Sakamaki T, Morita S, Kuroda T, Hirai T, Chin K. Murase K, et al. Among authors: kita h. Ann Am Thorac Soc. 2020 Mar;17(3):329-337. doi: 10.1513/AnnalsATS.201907-494OC. Ann Am Thorac Soc. 2020. PMID: 31689141 Clinical Trial.
Rationale: The effects of telemedicine on adherence in patients with obstructive sleep apnea with long-term continuous positive airway pressure (CPAP) use have never been investigated.Objectives: To examine effects of a telemedicine intervention on adherence in long-ter …
Rationale: The effects of telemedicine on adherence in patients with obstructive sleep apnea with long-term continuous positive airwa …
Eosinophilic Inflammation in Peritoneal Fibrosis Patients Undergoing Peritoneal Dialysis.
Kobayashi T, Noguchi T, Saito K, Shirasaki F, Kita H, Nagata M, Okada H, Nakamoto H. Kobayashi T, et al. Among authors: kita h. Contrib Nephrol. 2018;196:1-4. doi: 10.1159/000485689. Epub 2018 Jul 24. Contrib Nephrol. 2018. PMID: 30041197 Review.
One type of dialysis treatment is called peritoneal dialysis. Complications from long-term peritoneal dialysis include encapsulating peritoneal sclerosis (EPS), which can lead to life-threatening intestinal obstruction. ...
One type of dialysis treatment is called peritoneal dialysis. Complications from long-term peritoneal dialysis include encapsulating …
Neonatal hyperoxia promotes asthma-like features through IL-33-dependent ILC2 responses.
Cheon IS, Son YM, Jiang L, Goplen NP, Kaplan MH, Limper AH, Kita H, Paczesny S, Prakash YS, Tepper R, Ahlfeld SK, Sun J. Cheon IS, et al. Among authors: kita h. J Allergy Clin Immunol. 2018 Oct;142(4):1100-1112. doi: 10.1016/j.jaci.2017.11.025. Epub 2017 Dec 15. J Allergy Clin Immunol. 2018. PMID: 29253513 Free PMC article.
Assessments were performed at various time points for evaluation of airway hyperresponsiveness, eosinophilia, mucus production, inflammatory gene expression, and T(H) and group 2 innate lymphoid cell (ILC2) responses. Sera from term- and preterm-born infants were also coll …
Assessments were performed at various time points for evaluation of airway hyperresponsiveness, eosinophilia, mucus production, inflammatory …
Comparison of Different Disease-Specific Health-Related Quality of Life Measurements in Patients with Long-Term Noninvasive Ventilation.
Oga T, Taniguchi H, Kita H, Tsuboi T, Tomii K, Ando M, Kojima E, Tomioka H, Taguchi Y, Kaji Y, Maekura R, Hiraga T, Sakai N, Kimura T, Mishima M, Windisch W, Chin K. Oga T, et al. Among authors: kita h. Can Respir J. 2017;2017:8295079. doi: 10.1155/2017/8295079. Epub 2017 May 15. Can Respir J. 2017. PMID: 28588383 Free PMC article. Clinical Trial.
George's Respiratory Questionnaire (SGRQ) for use in patients with home noninvasive ventilation (NIV). METHODS: Fifty-six outpatients receiving long-term NIV were recruited and underwent assessments of pulmonary function, arterial blood gas, HRQL, dyspnea, and psychologica …
George's Respiratory Questionnaire (SGRQ) for use in patients with home noninvasive ventilation (NIV). METHODS: Fifty-six outpatients receiv …
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