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2012 1
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Visual short-term memory relates to tau and amyloid burdens in preclinical autosomal dominant Alzheimer's disease.
Norton DJ, Parra MA, Sperling RA, Baena A, Guzman-Velez E, Jin DS, Andrea N, Khang J, Schultz A, Rentz DM, Pardilla-Delgado E, Fuller J, Johnson K, Reiman EM, Lopera F, Quiroz YT. Norton DJ, et al. Alzheimers Res Ther. 2020 Aug 21;12(1):99. doi: 10.1186/s13195-020-00660-z. Alzheimers Res Ther. 2020. PMID: 32825838 Free PMC article.
BACKGROUND: Over the past decade, visual short-term memory (VSTM) binding tests have been shown to be one of the most sensitive behavioral indicators of Alzheimer's disease (AD), especially when they require the binding of multiple features (e.g., color and shape). ...
BACKGROUND: Over the past decade, visual short-term memory (VSTM) binding tests have been shown to be one of the most sensitive behav …
Short-term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive Impairment.
Grill JD, Raman R, Ernstrom K, Sultzer DL, Burns JM, Donohue MC, Johnson KA, Aisen PS, Sperling RA, Karlawish J; A4 Study Team. Grill JD, et al. JAMA Neurol. 2020 Dec 1;77(12):1504-1513. doi: 10.1001/jamaneurol.2020.2734. JAMA Neurol. 2020. PMID: 32777010 Free PMC article. Clinical Trial.
IMPORTANCE: The goal of preclinical Alzheimer disease (AD) clinical trials is to move diagnosis and treatment to presymptomatic stages, which will require biomarker testing and disclosure. OBJECTIVE: To assess the short-term psychological outcomes of disclosing amyloid pos …
IMPORTANCE: The goal of preclinical Alzheimer disease (AD) clinical trials is to move diagnosis and treatment to presymptomatic stages, whic …
Subjective cognitive concerns are associated with objective memory performance in Caucasian but not African-American persons.
Jackson JD, Rentz DM, Aghjayan SL, Buckley RF, Meneide TF, Sperling RA, Amariglio RE. Jackson JD, et al. Age Ageing. 2017 Nov 1;46(6):988-993. doi: 10.1093/ageing/afx077. Age Ageing. 2017. PMID: 29088363 Free PMC article.
No group differences were observed in the matched sample. The SCC race interaction term was nonsignificant in the full sample, beta = 0.109, P = 0.09, but was significant in the matched sample, beta = 0.422, P = 0.037. ...
No group differences were observed in the matched sample. The SCC race interaction term was nonsignificant in the full sample, beta = …
Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons.
Donohue MC, Sperling RA, Petersen R, Sun CK, Weiner MW, Aisen PS; Alzheimer’s Disease Neuroimaging Initiative. Donohue MC, et al. JAMA. 2017 Jun 13;317(22):2305-2316. doi: 10.1001/jama.2017.6669. JAMA. 2017. PMID: 28609533 Free PMC article.
Further research is needed to assess the clinical importance of these differences and measure longer-term associations....
Further research is needed to assess the clinical importance of these differences and measure longer-term associations....
Phases of Hyperconnectivity and Hypoconnectivity in the Default Mode and Salience Networks Track with Amyloid and Tau in Clinically Normal Individuals.
Schultz AP, Chhatwal JP, Hedden T, Mormino EC, Hanseeuw BJ, Sepulcre J, Huijbers W, LaPoint M, Buckley RF, Johnson KA, Sperling RA. Schultz AP, et al. J Neurosci. 2017 Apr 19;37(16):4323-4331. doi: 10.1523/JNEUROSCI.3263-16.2017. Epub 2017 Mar 17. J Neurosci. 2017. PMID: 28314821 Free PMC article.
We modeled fcMRI measures across four major cortical association networks [default-mode network (DMN), salience network (SAL), dorsal attention network, and frontoparietal control network] as a function of global cortical amyloid [Pittsburgh Compound B (PiB)-PET] and regional Tau …
We modeled fcMRI measures across four major cortical association networks [default-mode network (DMN), salience network (SAL), dorsal attent …
Cued memory decline in biomarker-defined preclinical Alzheimer disease.
Papp KV, Rentz DM, Mormino EC, Schultz AP, Amariglio RE, Quiroz Y, Johnson KA, Sperling RA. Papp KV, et al. Neurology. 2017 Apr 11;88(15):1431-1438. doi: 10.1212/WNL.0000000000003812. Epub 2017 Mar 10. Neurology. 2017. PMID: 28283594 Free PMC article.
CONCLUSIONS: Cued memory decline in healthy older adults may be particularly indicative of Abeta-related decline during the preclinical stage of AD and useful for identifying Abeta(+) clinically normal individuals at greatest risk of short-term clinical progression....
CONCLUSIONS: Cued memory decline in healthy older adults may be particularly indicative of Abeta-related decline during the preclinical stag …
Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals.
Mormino EC, Papp KV, Rentz DM, Schultz AP, LaPoint M, Amariglio R, Hanseeuw B, Marshall GA, Hedden T, Johnson KA, Sperling RA. Mormino EC, et al. JAMA Neurol. 2016 Oct 1;73(10):1185-1191. doi: 10.1001/jamaneurol.2016.2237. JAMA Neurol. 2016. PMID: 27548655 Free PMC article.
SNAP is likely heterogeneous, with a subset of this group at elevated risk for short-term decline. Future refinement of biomarkers will be necessary to subclassify this group and determine the biological correlates of ND markers among Abeta- CN individuals....
SNAP is likely heterogeneous, with a subset of this group at elevated risk for short-term decline. Future refinement of biomarkers wi …
Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument.
Amariglio RE, Donohue MC, Marshall GA, Rentz DM, Salmon DP, Ferris SH, Karantzoulis S, Aisen PS, Sperling RA; Alzheimer’s Disease Cooperative Study. Amariglio RE, et al. JAMA Neurol. 2015 Apr;72(4):446-54. doi: 10.1001/jamaneurol.2014.3375. JAMA Neurol. 2015. PMID: 25706191 Free PMC article.
Both self and partner CFI change were associated with longitudinal cognitive decline (self, rho=0.32, 95% CI, 0.13 to 0.46; partner, rho=0.56, 95% CI, 0.42 to 0.68), although findings suggest self-report may be more accurate early in the process, whereas accuracy of partner repor …
Both self and partner CFI change were associated with longitudinal cognitive decline (self, rho=0.32, 95% CI, 0.13 to 0.46; partner, rho=0.5 …
Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals.
Mormino EC, Betensky RA, Hedden T, Schultz AP, Amariglio RE, Rentz DM, Johnson KA, Sperling RA. Mormino EC, et al. JAMA Neurol. 2014 Nov;71(11):1379-85. doi: 10.1001/jamaneurol.2014.2031. JAMA Neurol. 2014. PMID: 25222039 Free PMC article.
IMPORTANCE: Assessing the ability of Alzheimer disease neuroimaging markers to predict short-term cognitive decline among clinically normal (CN) individuals is critical for upcoming secondary prevention trials using cognitive outcomes. ...Decline over time was observed onl …
IMPORTANCE: Assessing the ability of Alzheimer disease neuroimaging markers to predict short-term cognitive decline among clinically …
Amyloid and APOE epsilon4 interact to influence short-term decline in preclinical Alzheimer disease.
Mormino EC, Betensky RA, Hedden T, Schultz AP, Ward A, Huijbers W, Rentz DM, Johnson KA, Sperling RA; Alzheimer's Disease Neuroimaging Initiative; Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing; Harvard Aging Brain Study. Mormino EC, et al. Neurology. 2014 May 20;82(20):1760-7. doi: 10.1212/WNL.0000000000000431. Epub 2014 Apr 18. Neurology. 2014. PMID: 24748674 Free PMC article.
11 results