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VWA3A-derived ependyma promoter drives increased therapeutic protein secretion into the CSF.
Carrell EM, Chen YH, Ranum PT, Coffin SL, Singh LN, Tecedor L, Keiser MS, Hudry E, Hyman BT, Davidson BL. Carrell EM, et al. Among authors: hyman bt. Mol Ther Nucleic Acids. 2023 Jul 15;33:296-304. doi: 10.1016/j.omtn.2023.07.016. eCollection 2023 Sep 12. Mol Ther Nucleic Acids. 2023. PMID: 37547292 Free PMC article.
Recombinant adeno-associated viral vectors (rAAVs) are a promising strategy to treat neurodegenerative diseases because of their ability to infect non-dividing cells and confer long-term transgene expression. Despite an ever-growing library of capsid variants, widespread d …
Recombinant adeno-associated viral vectors (rAAVs) are a promising strategy to treat neurodegenerative diseases because of their ability to …
Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imaging.
Zwang TJ, Woost B, Bailey J, Hoglund Z, Richardson DS, Bennett RE, Hyman BT. Zwang TJ, et al. Among authors: hyman bt. Brain Commun. 2023 Apr 19;5(3):fcad130. doi: 10.1093/braincomms/fcad130. eCollection 2023. Brain Commun. 2023. PMID: 37324243 Free PMC article.
For example, it is well established that neurofibrillary tangles begin within a neuron, and ultimately, in at least some instances, persist in the brain even after the neuron has died. These are referred to as 'ghost tangles', a term that appropriately implies their 'diffi …
For example, it is well established that neurofibrillary tangles begin within a neuron, and ultimately, in at least some instances, persist …
Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition.
Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, Feldman HA, Holland D, McEvoy LK, Hyman BT, Bennett DA, Andreassen OA, Dale AM, Desikan RS; Alzheimer’s Disease Neuroimaging Initiative. Tan CH, et al. Among authors: hyman bt. Acta Neuropathol. 2018 Jan;135(1):85-93. doi: 10.1007/s00401-017-1789-4. Epub 2017 Nov 24. Acta Neuropathol. 2018. PMID: 29177679 Free PMC article.
Together, our results show that even after accounting for APOE epsilon4 effects, PHS may be useful in MCI and preclinical AD therapeutic trials to enrich for biomarker-positive individuals at highest risk for short-term clinical progression....
Together, our results show that even after accounting for APOE epsilon4 effects, PHS may be useful in MCI and preclinical AD therapeutic tri …
A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease.
Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E. Hori Y, et al. Among authors: hyman bt. J Biol Chem. 2015 Jan 23;290(4):1966-78. doi: 10.1074/jbc.M114.586602. Epub 2014 Dec 2. J Biol Chem. 2015. PMID: 25468905 Free PMC article.
These data suggest a clear effect of a peripherally administered, Food and Drug Administration-approved medication on Abeta economy, supporting further investigation of the potential long-term efficacy of cromolyn sodium in Alzheimer disease....
These data suggest a clear effect of a peripherally administered, Food and Drug Administration-approved medication on Abeta economy, support …
Primary age-related tauopathy (PART): a common pathology associated with human aging.
Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jellinger K, Jicha GA, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee A, Montine TJ, Murray ME, Neltner JH, Santa-Maria I, Seeley WW, Serrano-Pozo A, Shelanski ML, Stein T, Takao M, Thal DR, Toledo JB, Troncoso JC, Vonsattel JP, White CL 3rd, Wisniewski T, Woltjer RL, Yamada M, Nelson PT. Crary JF, et al. Among authors: hyman bt. Acta Neuropathol. 2014 Dec;128(6):755-66. doi: 10.1007/s00401-014-1349-0. Epub 2014 Oct 28. Acta Neuropathol. 2014. PMID: 25348064 Free PMC article.
We recommend a new term, "primary age-related tauopathy" (PART), to describe a pathology that is commonly observed in the brains of aged individuals. ...
We recommend a new term, "primary age-related tauopathy" (PART), to describe a pathology that is commonly observed in the brains of a …
Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV.
Grishchuk Y, Sri S, Rudinskiy N, Ma W, Stember KG, Cottle MW, Sapp E, Difiglia M, Muzikansky A, Betensky RA, Wong AM, Bacskai BJ, Hyman BT, Kelleher RJ 3rd, Cooper JD, Slaugenhaupt SA. Grishchuk Y, et al. Among authors: hyman bt. Acta Neuropathol Commun. 2014 Sep 9;2:133. doi: 10.1186/s40478-014-0133-7. Acta Neuropathol Commun. 2014. PMID: 25200117 Free PMC article.
Despite the absence of neuron loss, we observed alterations in synaptic plasticity, as indicated by elevated paired-pulse facilitation and enhanced long-term potentiation. Myelination deficits and severely dysmorphic corpus callosum were present early and resembled white m …
Despite the absence of neuron loss, we observed alterations in synaptic plasticity, as indicated by elevated paired-pulse facilitation and e …
Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses.
Rudinskiy N, Hawkes JM, Wegmann S, Kuchibhotla KV, Muzikansky A, Betensky RA, Spires-Jones TL, Hyman BT. Rudinskiy N, et al. Among authors: hyman bt. Acta Neuropathol Commun. 2014 Jun 10;2:63. doi: 10.1186/2051-5960-2-63. Acta Neuropathol Commun. 2014. PMID: 24915991 Free PMC article.
Here we used a transgenic mouse model of tauopathy to study how advanced tau pathology in different brain regions affects activity-driven expression of immediate-early gene Arc required for experience-dependent consolidation of long-term memories. We demonstrate in vivo th …
Here we used a transgenic mouse model of tauopathy to study how advanced tau pathology in different brain regions affects activity-driven ex …
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.
Kim T, Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, Hyman BT, Shatz CJ. Kim T, et al. Among authors: hyman bt. Science. 2013 Sep 20;341(6152):1399-404. doi: 10.1126/science.1242077. Science. 2013. PMID: 24052308 Free PMC article.
In mice, the deleterious effect of Abeta oligomers on hippocampal long-term potentiation required PirB, and in a transgenic model of AD, PirB not only contributed to memory deficits present in adult mice, but also mediated loss of synaptic plasticity in juvenile visual cor …
In mice, the deleterious effect of Abeta oligomers on hippocampal long-term potentiation required PirB, and in a transgenic model of …
Improved design of prodromal Alzheimer's disease trials through cohort enrichment and surrogate endpoints.
Macklin EA, Blacker D, Hyman BT, Betensky RA. Macklin EA, et al. Among authors: hyman bt. J Alzheimers Dis. 2013;36(3):475-86. doi: 10.3233/JAD-122212. J Alzheimers Dis. 2013. PMID: 23629586 Free PMC article.
We hypothesized that design of such trials could be improved by: 1) selecting individuals at moderate near-term risk of progression to AD dementia (the current clinical standard) and 2) by using short-term surrogate endpoints that predict progression to AD dementia. …
We hypothesized that design of such trials could be improved by: 1) selecting individuals at moderate near-term risk of progression t …
Alzheimer's disease: synapses gone cold.
Koffie RM, Hyman BT, Spires-Jones TL. Koffie RM, et al. Among authors: hyman bt. Mol Neurodegener. 2011 Aug 26;6(1):63. doi: 10.1186/1750-1326-6-63. Mol Neurodegener. 2011. PMID: 21871088 Free PMC article.
Soluble oligomeric forms of amyloid beta (Abeta), the peptide that aggregates to form senile plaques in the brain of AD patients, have been shown to be toxic to neuronal synapses both in vitro and in vivo. Abeta oligomers inhibit long-term potentiation (LTP) and facilitate …
Soluble oligomeric forms of amyloid beta (Abeta), the peptide that aggregates to form senile plaques in the brain of AD patients, have been …
21 results