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Results from the long-term extension of PRIME: A randomized Phase 1b trial of aducanumab.
Chen T, O'Gorman J, Castrillo-Viguera C, Rajagovindan R, Curiale GG, Tian Y, Patel D, von Rosenstiel P, von Hehn C, Salloway S, Hock C, Nitsch RM, Haeberlein SB, Sandrock A, Singhal P. Chen T, et al. Among authors: hock c. Alzheimers Dement. 2024 Apr 3. doi: 10.1002/alz.13755. Online ahead of print. Alzheimers Dement. 2024. PMID: 38567735
During the 12-month placebo-controlled period, participants with prodromal AD or mild AD dementia were randomized to receive aducanumab or placebo. At week 56, participants could enroll in a long-term extension (LTE), in which all participants received aducanumab. ...
During the 12-month placebo-controlled period, participants with prodromal AD or mild AD dementia were randomized to receive aducanumab or p …
Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease.
Jambeau M, Meyer KD, Hruska-Plochan M, Tabet R, Lee CZ, Ray-Soni A, Aguilar C, Savage K, Mishra N, Cavegn N, Borter P, Lin CC, Jansen-West KR, Jiang J, Freyermuth F, Li N, De Rossi P, Pérez-Berlanga M, Jiang X, Daughrity LM, Pereira J, Narayanan S, Gu Y, Dhokai S, Dalkilic-Liddle I, Maniecka Z, Weber J, Workman M, McAlonis-Downes M, Berezovski E, Zhang YJ, Berry J, Wainger BJ, Kankel MW, Rushe M, Hock C, Nitsch RM, Cleveland DW, Petrucelli L, Gendron TF, Montrasio F, Grimm J, Polymenidou M, Lagier-Tourenne C. Jambeau M, et al. Among authors: hock c. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2123487119. doi: 10.1073/pnas.2123487119. Epub 2022 Dec 1. Proc Natl Acad Sci U S A. 2022. PMID: 36454749 Free PMC article.
Targeting poly-GA and poly-GP in two mouse models expressing G(4)C(2) repeats by systemic antibody delivery for up to 16 mo was well-tolerated and led to measurable brain penetration of antibodies. Long-term treatment with anti-GA antibodies produced improvement in an open …
Targeting poly-GA and poly-GP in two mouse models expressing G(4)C(2) repeats by systemic antibody delivery for up to 16 mo was well-tolerat …
Increased cerebral blood volume in small arterial vessels is a correlate of amyloid-β-related cognitive decline.
Hua J, Lee S, Blair NIS, Wyss M, van Bergen JMG, Schreiner SJ, Kagerer SM, Leh SE, Gietl AF, Treyer V, Buck A, Nitsch RM, Pruessmann KP, Lu H, Van Zijl PCM, Albert M, Hock C, Unschuld PG. Hua J, et al. Among authors: hock c. Neurobiol Aging. 2019 Apr;76:181-193. doi: 10.1016/j.neurobiolaging.2019.01.001. Epub 2019 Jan 10. Neurobiol Aging. 2019. PMID: 30738323 Free PMC article.
The protracted accumulation of amyloid-beta (Abeta) is a major pathologic hallmark of Alzheimer's disease and may trigger secondary pathological processes that include neurovascular damage. This study was aimed at investigating long-term effects of Abeta burden on cerebral …
The protracted accumulation of amyloid-beta (Abeta) is a major pathologic hallmark of Alzheimer's disease and may trigger secondary patholog …
Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease.
Quevenco FC, Preti MG, van Bergen JM, Hua J, Wyss M, Li X, Schreiner SJ, Steininger SC, Meyer R, Meier IB, Brickman AM, Leh SE, Gietl AF, Buck A, Nitsch RM, Pruessmann KP, van Zijl PC, Hock C, Van De Ville D, Unschuld PG. Quevenco FC, et al. Among authors: hock c. Alzheimers Res Ther. 2017 Mar 31;9(1):24. doi: 10.1186/s13195-017-0249-7. Alzheimers Res Ther. 2017. PMID: 28359293 Free PMC article.
The purpose of this study was to investigate the relationship between cerebral dynamic functional connectivity and variability of long-term cognitive performance in healthy, elderly subjects, allowing for local pathology and genetic risk. ...
The purpose of this study was to investigate the relationship between cerebral dynamic functional connectivity and variability of long-te …
Microscopic lumbar spinal stenosis decompression: is surgical education safe?
Joswig H, Hock C, Hildebrandt G, Schaller K, Stienen MN. Joswig H, et al. Among authors: hock c. Acta Neurochir (Wien). 2016 Feb;158(2):357-66. doi: 10.1007/s00701-015-2667-2. Epub 2015 Dec 19. Acta Neurochir (Wien). 2016. PMID: 26687377
Until final FU, the likelihood for patients in the teaching group to suffer from postoperative complications (OR 1.07, 95 % CI 0.46-2.49, p = 0.864) or require re-do surgery (OR 0.68, 95 % CI 0.31-1.52, p = 0.358) was similar to that of the non-teaching group. CONCLUSIONS: Compli …
Until final FU, the likelihood for patients in the teaching group to suffer from postoperative complications (OR 1.07, 95 % CI 0.46-2.49, p …
Comparison of venous and HePTFE tibial and peroneal bypasses in critical limb ischemia patients unsuitable for endovascular revascularization.
Uhl C, Hock C, Betz T, Greindl M, Töpel I, Steinbauer M. Uhl C, et al. Among authors: hock c. Vascular. 2015 Dec;23(6):607-13. doi: 10.1177/1708538114568701. Epub 2015 Jan 26. Vascular. 2015. PMID: 25623028
BACKGROUND: We examined short- and long-term outcomes of tibial and peroneal venous and heparin-bonded expanded polytetrafluoroethylene bypasses in patients with critical limb ischemia who were unsuitable for endovascular revascularization. ...
BACKGROUND: We examined short- and long-term outcomes of tibial and peroneal venous and heparin-bonded expanded polytetrafluoroethyle …
The impact of infrainguinal endovascular interventions on the results of subsequent femoro-tibial bypass procedures: a retrospective cohort study.
Uhl C, Hock C, Betz T, Bröckner S, Töpel I, Steinbauer M. Uhl C, et al. Among authors: hock c. Int J Surg. 2015 Jan;13:261-266. doi: 10.1016/j.ijsu.2014.12.010. Epub 2014 Dec 18. Int J Surg. 2015. PMID: 25528633 Free article.
We analyzed the impact of prior endovascular lower extremity revascularization procedures on the short- and mid-term results of femoro-tibial and femoro-peroneal bypasses. METHODS: A retrospective analysis was conducted of all patients who had undergone tibial or peroneal …
We analyzed the impact of prior endovascular lower extremity revascularization procedures on the short- and mid-term results of femor …
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