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The short-term toxicity and metabolome of dicyclopentadiene.
van Ravenzwaay B, Kocabas NA, Faulhammer F, Flick B, Giri V, Sperber S, Penman MG, Higgins LG, Kamp H, Rooseboom M. van Ravenzwaay B, et al. Among authors: higgins lg. Toxicol Lett. 2024 Mar;393:57-68. doi: 10.1016/j.toxlet.2024.01.005. Epub 2024 Jan 12. Toxicol Lett. 2024. PMID: 38219808 Free article.
Importantly no other types of organ toxicity, or hormone dysregulation beyond the ones associated with liver enzyme induction and stress were indicated, again in line with results of published 90-day studies. It is therefore suggested that short term "smart" studies, combi …
Importantly no other types of organ toxicity, or hormone dysregulation beyond the ones associated with liver enzyme induction and stress wer …
Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator.
Nudischer R, Renggli K, Bertinetti-Lapatki C, Hoflack JC, Flint N, Sewing S, Pedersen L, Schadt S, Higgins LG, Vardy A, Lenz B, Gand L, Boess F, Elcombe BM, Hierlemann A, Roth AB. Nudischer R, et al. Among authors: higgins lg. Toxicol Sci. 2020 Aug 1;176(2):329-342. doi: 10.1093/toxsci/kfaa076. Toxicol Sci. 2020. PMID: 32458970
Basimglurant (RG7090), a small molecule under development to treat certain forms of depression, demonstrated foci of altered hepatocytes in a long-term rodent-toxicity study. Additional evidence pointed toward the activation of the constitutive androstane receptor (CAR), a …
Basimglurant (RG7090), a small molecule under development to treat certain forms of depression, demonstrated foci of altered hepatocytes in …