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Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial.
White RJ, Jerjes-Sanchez C, Bohns Meyer GM, Pulido T, Sepulveda P, Wang KY, Grünig E, Hiremath S, Yu Z, Gangcheng Z, Yip WLJ, Zhang S, Khan A, Deng CQ, Grover R, Tapson VF; FREEDOM-EV Investigators. White RJ, et al. Am J Respir Crit Care Med. 2020 Mar 15;201(6):707-717. doi: 10.1164/rccm.201908-1640OC. Am J Respir Crit Care Med. 2020. PMID: 31765604 Free PMC article. Clinical Trial.
The primary endpoint was the time to first adjudicated clinical worsening event: death; hospitalization due to worsening PAH; initiation of inhaled or parenteral prostacyclin therapy; disease progression; or unsatisfactory long-term clinical response.Measurements and Main …
The primary endpoint was the time to first adjudicated clinical worsening event: death; hospitalization due to worsening PAH; initiation of …
Topical ocular protein delivery based on protein powder suspensions in semifluorinated alkanes.
Marschall C, Filster J, Witt M, Hauptmeier B, Frieß W. Marschall C, et al. Among authors: hauptmeier b. Eur J Pharm Biopharm. 2023 Aug;189:233-239. doi: 10.1016/j.ejpb.2023.06.014. Epub 2023 Jun 23. Eur J Pharm Biopharm. 2023. PMID: 37356639
Furthermore, stability studies for bevacizumab suspensions in semifluorinated alkanes were investigated and showed superior long-term stability compared to the marketed aqueous solution. Overall results demonstrate the high potential of topical ocular protein delivery usin …
Furthermore, stability studies for bevacizumab suspensions in semifluorinated alkanes were investigated and showed superior long-term …
Undiagnosed Diabetes Mellitus in Community-Acquired Pneumonia: A Prospective Cohort Study.
Jensen AV, Faurholt-Jepsen D, Egelund GB, Andersen SB, Petersen PT, Benfield T, Witzenrath M, Rohde G, Ravn P; German Community-Acquired Pneumonia Competence Network (CAPNETZ); German Community-Acquired Pneumonia Competence Network (CAPNETZ). Jensen AV, et al. Clin Infect Dis. 2017 Nov 29;65(12):2091-2098. doi: 10.1093/cid/cix703. Clin Infect Dis. 2017. PMID: 29095981
Male sex, overweight, and hyperglycemia at admission were associated with undiagnosed diabetes mellitus. The long-term mortality among patients with undiagnosed diabetes mellitus was high compared to patients without diabetes mellitus....
Male sex, overweight, and hyperglycemia at admission were associated with undiagnosed diabetes mellitus. The long-term mortality amon …
Presentation, etiology and outcome of pneumonia in younger nursing home residents.
Klapdor B, Ewig S, Schaberg T, Rohde G, Pletz MW, Schütte H, Welte T; CAPNETZ study group. Klapdor B, et al. J Infect. 2012 Jul;65(1):32-8. doi: 10.1016/j.jinf.2012.02.003. Epub 2012 Feb 10. J Infect. 2012. PMID: 22330772
According to the CRB-65 score, NHAP presentation was less severe in the younger patients. Short- and long-term mortality was twice as low in the younger patients with rates of 12.9% vs 26.6%, and 24.3% vs 43.8%, p = 0.014 and 0.002), respectively. ...
According to the CRB-65 score, NHAP presentation was less severe in the younger patients. Short- and long-term mortality was twice as …
Impact of pneumococcal vaccination in children on serotype distribution in adult community-acquired pneumonia using the serotype-specific multiplex urinary antigen detection assay.
Pletz MW, Ewig S, Rohde G, Schuette H, Rupp J, Welte T, Suttorp N, Forstner C; CAPNETZ Study Group. Pletz MW, et al. Vaccine. 2016 Apr 29;34(20):2342-8. doi: 10.1016/j.vaccine.2016.03.052. Epub 2016 Mar 24. Vaccine. 2016. PMID: 27016653
Vaccination of children started with PCV7 in 2007, which was replaced by PCV13 in 2010. Following confirmation of the accuracy of SSUA in long-term stored urine samples from 112 patients with confirmed pneumonia and known pneumococcal serotype, urine samples of 391 CAPNETZ …
Vaccination of children started with PCV7 in 2007, which was replaced by PCV13 in 2010. Following confirmation of the accuracy of SSUA in lo …
Randomized double blind placebo-controlled study to demonstrate that antibiotics are not needed in moderate acute exacerbations of COPD--the ABACOPD study.
Rohde GG, Koch A, Welte T; ABACOPD study group. Rohde GG, et al. BMC Pulm Med. 2015 Jan 27;15:5. doi: 10.1186/1471-2466-15-5. BMC Pulm Med. 2015. PMID: 25623589 Free PMC article. Clinical Trial.
Secondary endpoints will assure that management of AE-COPD without antibiotics does not result either in increased occurrence of relapse, new exacerbations, prolonged recovery, or unwanted long-term consequences. DISCUSSION: ABACOPD will be the first sufficiently powered d …
Secondary endpoints will assure that management of AE-COPD without antibiotics does not result either in increased occurrence of relapse, ne …
[Daytime ventilatory efficiency in obstructive sleep apnea syndrome--influence of CPAP-therapy].
Duchna HW, Hauptmeier B, Orth M, Schultze-Werninghaus G, Schäfer T. Duchna HW, et al. Among authors: hauptmeier b. Pneumologie. 2007 Aug;61(8):509-16. doi: 10.1055/s-2007-959244. Epub 2007 Jun 5. Pneumologie. 2007. PMID: 17551883 German.
CONCLUSIONS: OSAS is not associated with a disturbed ventilatory efficiency during exercise. Long-term CPAP-therapy does not change ventilatory efficiency during exercise in patients with OSAS. ...
CONCLUSIONS: OSAS is not associated with a disturbed ventilatory efficiency during exercise. Long-term CPAP-therapy does not change v …