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Adaptations to chronic rapamycin in mice.
Dodds SG, Livi CB, Parihar M, Hsu HK, Benavides AD, Morris J, Javors M, Strong R, Christy B, Hasty P, Sharp ZD. Dodds SG, et al. Among authors: hasty p. Pathobiol Aging Age Relat Dis. 2016 May 27;6:31688. doi: 10.3402/pba.v6.31688. eCollection 2016. Pathobiol Aging Age Relat Dis. 2016. PMID: 27237224 Free PMC article.
Chronic treatment with encapsulated rapamycin (eRapa) extended health and life span for wild-type and cancer-prone mice. Yet, the long-term consequences of chronic eRapa treatment are not known at the organ level. ...
Chronic treatment with encapsulated rapamycin (eRapa) extended health and life span for wild-type and cancer-prone mice. Yet, the long-te …
Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.
Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, Bergman M, Orihuela CJ, Galvan V, Padrón Á, Drerup J, Liu Y, Hasty P, Sharp ZD, Curiel TJ. Hurez V, et al. Among authors: hasty p. Aging Cell. 2015 Dec;14(6):945-56. doi: 10.1111/acel.12380. Epub 2015 Aug 28. Aging Cell. 2015. PMID: 26315673 Free PMC article.
Rapamycin or related analogues (rapalogues) also mitigate age-related debilities including increasing antigen-specific immunity, improving vaccine responses in elderly humans, and treating cancers and autoimmunity, suggesting important new clinical applications. Nonetheless, immu …
Rapamycin or related analogues (rapalogues) also mitigate age-related debilities including increasing antigen-specific immunity, improving v …
Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors.
Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD. Livi CB, et al. Among authors: hasty p. Aging (Albany NY). 2013 Feb;5(2):100-10. doi: 10.18632/aging.100533. Aging (Albany NY). 2013. PMID: 23454836 Free PMC article.
Previous results showed that diet restriction (DR) had minimal or no effect on the lifespan of Rb1+/- mice, suggesting that the beneficial response to DR is dependent on pRb1. Since long-term eRapa treatment may at least partially mimic chronic DR in lifespan extension, we …
Previous results showed that diet restriction (DR) had minimal or no effect on the lifespan of Rb1+/- mice, suggesting that the beneficial r …
Gene targeting in mouse embryonic stem cells with an adenoviral vector.
Mitani K, Wakamiya M, Hasty P, Graham FL, Bradley A, Caskey CT. Mitani K, et al. Among authors: hasty p. Somat Cell Mol Genet. 1995 Jul;21(4):221-31. doi: 10.1007/BF02255777. Somat Cell Mol Genet. 1995. PMID: 8525428
Our results suggest that it is possible to modify the structure of an adenoviral vector to achieve a high gene targeting efficiency, resulting in regulated and long-term expression of an introduced gene....
Our results suggest that it is possible to modify the structure of an adenoviral vector to achieve a high gene targeting efficiency, resulti …