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Longitudinal analysis of genomic mutations in SARS-CoV-2 isolates from persistent COVID-19 patient.
Futatsusako H, Hashimoto R, Yamamoto M, Ito J, Matsumura Y, Yoshifuji H, Shirakawa K, Takaori-Kondo A; Genotype to Phenotype Japan (G2P-Japan) Consortium; Sato K, Nagao M, Takayama K. Futatsusako H, et al. Among authors: hashimoto r. iScience. 2024 Mar 29;27(5):109597. doi: 10.1016/j.isci.2024.109597. eCollection 2024 May 17. iScience. 2024. PMID: 38638575 Free PMC article.
These results suggest mutations in SARS-CoV-2 are acquired during long-term viral replication rather than in response to antiviral drugs....
These results suggest mutations in SARS-CoV-2 are acquired during long-term viral replication rather than in response to antiviral dr …
Exploring the genetics of lithium response in bipolar disorders.
Herrera-Rivero M, Adli M, Akiyama K, Akula N, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Bellivier F, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Cearns M, Cervantes P, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cruceanu C, Czerski PM, Dalkner N, Degenhardt F, Del Zompo M, DePaulo JR, Etain B, Falkai P, Ferensztajn-Rochowiak E, Forstner AJ, Frank J, Frisén L, Frye MA, Fullerton JM, Gallo C, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hasler R, Hauser J, Heilbronner U, Herms S, Hoffmann P, Hou L, Hsu YH, Jamain S, Jiménez E, Kahn JP, Kassem L, Kato T, Kelsoe J, Kittel-Schneider S, Kuo PH, Kusumi I, König B, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Maj M, Manchia M, Marie-Claire C, Martinsson L, McCarthy MJ, McElroy SL, Millischer V, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Novák T, Nöthen MM, O'Donovan C, Ozaki N, Papiol S, Pfennig A, Pisanu C, Potash JB, Reif A, Reininghaus E, Richard-Lepouriel H, Roberts G, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert KO, Schulte EC, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina… See abstract for full author list ➔ Herrera-Rivero M, et al. Among authors: hashimoto r. Res Sq [Preprint]. 2023 Dec 2:rs.3.rs-3677630. doi: 10.21203/rs.3.rs-3677630/v1. Res Sq. 2023. PMID: 38077040 Free PMC article. Preprint.
BACKGROUND: Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. ...BP-I and BP-II) according to the clinical presentation. Moreover …
BACKGROUND: Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-te …
Risk factors for recurrence of suicide attempt via overdose: A prospective observational study.
Suekane A, Takayama W, Hashimoto R, Morishita K, Otomo Y. Suekane A, et al. Among authors: hashimoto r. Am J Emerg Med. 2024 Jan;75:1-6. doi: 10.1016/j.ajem.2023.10.016. Epub 2023 Oct 20. Am J Emerg Med. 2024. PMID: 37890336
CONCLUSIONS: A history of schizophrenia was an independent risk factor for the recurrence of overdose, and the presence of a cohabitant was significantly associated with a lower risk of recurrence. Large-scale, long-term studies are required to confirm the results of this …
CONCLUSIONS: A history of schizophrenia was an independent risk factor for the recurrence of overdose, and the presence of a cohabitant was …
The Effects of Mucopolysaccharide Polysulfate on Steroid-Induced Tight Junction Barrier Dysfunction in Human Epidermal Keratinocytes and a 3D Skin Model.
Koda A, Ishii Y, Kashiwagi A, Fujikawa M, Kikuchi K, Hashimoto R, Ueda Y, Doi T. Koda A, et al. Among authors: hashimoto r. Skin Pharmacol Physiol. 2023;36(4):186-194. doi: 10.1159/000529962. Epub 2023 Mar 25. Skin Pharmacol Physiol. 2023. PMID: 36966539 Free PMC article.
INTRODUCTION: The long-term use of topical corticosteroids (TCS) is associated with side effects such as skin atrophy and barrier deterioration. ...
INTRODUCTION: The long-term use of topical corticosteroids (TCS) is associated with side effects such as skin atrophy and barrier det …
Long-term glucocorticoid treatment increases CD204 expression by activating the MAPK pathway and enhances modified LDL uptake in murine macrophages.
Hashimoto R, Koide H, Katoh Y. Hashimoto R, et al. J Pharmacol Sci. 2023 Jan;151(1):46-53. doi: 10.1016/j.jphs.2022.11.003. Epub 2022 Nov 17. J Pharmacol Sci. 2023. PMID: 36522122 Free article.
Although glucocorticoids are suspected to exacerbate atherosclerosis, the precise mechanisms have not been fully elucidated. We investigated the effects of long-term treatment (2 weeks) with both a natural glucocorticoid (hydrocortisone, HC, 1 muM) and a synthetic glucocor …
Although glucocorticoids are suspected to exacerbate atherosclerosis, the precise mechanisms have not been fully elucidated. We investigated …
Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study.
Coombes BJ, Millischer V, Batzler A, Larrabee B, Hou L, Papiol S, Heilbronner U, Adli M, Akiyama K, Akula N, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Bauer M, Baune BT, Bellivier F, Benabarre A, Bengesser S, Bhattacharjee AK, Cervantes P, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cruceanu C, Czerski PM, Dalkner N, Degenhardt F, Del Zompo M, DePaulo JR, Étain B, Falkai P, Ferensztajn-Rochowiak E, Forstner AJ, Frisen L, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hashimoto R, Hauser J, Herms S, Hoffmann P, Jamain S, Jiménez E, Kahn JP, Kassem L, Kato T, Kelsoe JR, Kittel-Schneider S, König B, Kuo PH, Kusumi I, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Novák T, O'Donovan C, Osby U, Ozaki N, Pfennig A, Pisanu C, Potash JB, Reif A, Reininghaus E, Rietschel M, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert KO, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Tortorella A, Turecki G, Vieta E, Witt SH, Zandi PP, Full… See abstract for full author list ➔ Coombes BJ, et al. Among authors: hashimoto r. Complex Psychiatry. 2021 Dec;7(3-4):80-89. doi: 10.1159/000519707. Epub 2021 Nov 18. Complex Psychiatry. 2021. PMID: 36408127 Free PMC article.
Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (N = 2,510) with BD were assessed for long-term lithium response in the Consortium on Lithium Genetics using the Retrospective Criteria of Long-Term Treatm …
Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (N = 2,510) with BD were asse …
Structural and Mechanical Properties of Konjac Glucomannan Gels and Influence of Freezing-Thawing Treatments on Them.
Takeno H, Hashimoto R, Lu Y, Hsieh WC. Takeno H, et al. Among authors: hashimoto r. Polymers (Basel). 2022 Sep 6;14(18):3703. doi: 10.3390/polym14183703. Polymers (Basel). 2022. PMID: 36145848 Free PMC article.
Freezing has been widely used for long-term food preservation. However, freezing-thawing (FT) treatment usually influences the texture and structure of food gels such as konjac. ...
Freezing has been widely used for long-term food preservation. However, freezing-thawing (FT) treatment usually influences the textur …
Prescription of Anticholinergic Drugs in Patients With Schizophrenia: Analysis of Antipsychotic Prescription Patterns and Hospital Characteristics.
Hori H, Yasui-Furukori N, Hasegawa N, Iga JI, Ochi S, Ichihashi K, Furihata R, Kyo Y, Takaesu Y, Tsuboi T, Kodaka F, Onitsuka T, Okada T, Murata A, Kashiwagi H, Iida H, Hashimoto N, Ohi K, Yamada H, Ogasawara K, Yasuda Y, Muraoka H, Usami M, Numata S, Takeshima M, Yamagata H, Nagasawa T, Tagata H, Makinodan M, Kido M, Katsumoto E, Komatsu H, Matsumoto J, Kubota C, Miura K, Hishimoto A, Watanabe K, Inada K, Kawasaki H, Hashimoto R. Hori H, et al. Among authors: hashimoto r. Front Psychiatry. 2022 May 17;13:823826. doi: 10.3389/fpsyt.2022.823826. eCollection 2022. Front Psychiatry. 2022. PMID: 35656353 Free PMC article.
In several clinical guidelines for schizophrenia, long-term use of anticholinergic drugs is not recommended. We investigated the characteristics of the use of anticholinergics in patients with schizophrenia by considering psychotropic prescription patterns and differences …
In several clinical guidelines for schizophrenia, long-term use of anticholinergic drugs is not recommended. We investigated the char …
Long-term follow-up of retinal morphology and physiology after 2000 mg sildenafil overdose as a means of attempted suicide: a case report.
Miura G, Baba T, Hashimoto R, Yamamoto S. Miura G, et al. Among authors: hashimoto r. BMC Ophthalmol. 2022 May 12;22(1):216. doi: 10.1186/s12886-022-02426-7. BMC Ophthalmol. 2022. PMID: 35549694 Free PMC article.
We report retinal morphology, retinal sensitivity, and findings of electrophysiological evaluation over long-term follow-up in a case of sildenafil overdose (2000 mg). CASE PRESENTATION: Our patient developed visual abnormalities in the paracentral visual field accompanied …
We report retinal morphology, retinal sensitivity, and findings of electrophysiological evaluation over long-term follow-up in a case …
SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response.
Tsuji S, Minami S, Hashimoto R, Konishi Y, Suzuki T, Kondo T, Sasai M, Torii S, Ono C, Shichinohe S, Sato S, Wakita M, Okumura S, Nakano S, Matsudaira T, Matsumoto T, Kawamoto S, Yamamoto M, Watanabe T, Matsuura Y, Takayama K, Kobayashi T, Okamoto T, Hara E. Tsuji S, et al. Among authors: hashimoto r. Nat Aging. 2022 Feb;2(2):115-124. doi: 10.1038/s43587-022-00170-7. Epub 2022 Jan 25. Nat Aging. 2022. PMID: 37117754 Free PMC article.
The sustained infection-induced paracrine senescence described here may be involved in the long-term inflammation caused by SARS-CoV-2 infection....
The sustained infection-induced paracrine senescence described here may be involved in the long-term inflammation caused by SARS-CoV- …
72 results