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Association of Long-Term Blood Pressure Variability with Cerebral Amyloid Angiopathy-related Brain Injury and Cognitive Decline.
Sveikata L, Zotin MCZ, Schoemaker D, Ma Y, Perosa V, Chokesuwattanaskul A, Charidimou A, Duering M, Gurol EM, Assal F, Greenberg SM, Viswanathan A. Sveikata L, et al. Among authors: greenberg sm. medRxiv [Preprint]. 2024 Feb 27:2024.02.24.24303071. doi: 10.1101/2024.02.24.24303071. medRxiv. 2024. PMID: 38464316 Free PMC article. Preprint.
INTRODUCTION: Long-term systolic blood pressure variability (BPV) has been proposed as a novel risk factor for dementia, but the underlying mechanisms are largely unknown. We aimed to investigate the association between long-term blood pressure variability (BPV), br …
INTRODUCTION: Long-term systolic blood pressure variability (BPV) has been proposed as a novel risk factor for dementia, but the unde …
Association of Depression Onset and Treatment With Blood Pressure Control After Intracerebral Hemorrhage.
Keins S, Abramson JR, Mallick A, Castello JP, Rodriguez-Torres A, Popescu D, Hoffman D, Kourkoulis C, Gurol ME, Greenberg SM, Anderson CD, Viswanathan A, Rosand J, Biffi A. Keins S, et al. Among authors: greenberg sm. Stroke. 2023 Jan;54(1):105-112. doi: 10.1161/STROKEAHA.122.040331. Epub 2022 Nov 29. Stroke. 2023. PMID: 36444719
BACKGROUND: Blood pressure (BP) control represents a crucial intervention to improve long-term outcomes following spontaneous intracerebral hemorrhage (ICH). ...Primary outcomes included systolic and diastolic BP measurements during long-term follow-up after ICH. RE …
BACKGROUND: Blood pressure (BP) control represents a crucial intervention to improve long-term outcomes following spontaneous intrace …
Endovascular Treatment and Thrombolysis for Acute Ischemic Stroke in Patients With Premorbid Disability or Dementia: A Scientific Statement From the American Heart Association/American Stroke Association.
Ganesh A, Fraser JF, Gordon Perue GL, Amin-Hanjani S, Leslie-Mazwi TM, Greenberg SM, Couillard P, Asdaghi N, Goyal M; American Heart Association Stroke Council. Ganesh A, et al. Among authors: greenberg sm. Stroke. 2022 May;53(5):e204-e217. doi: 10.1161/STR.0000000000000406. Epub 2022 Mar 28. Stroke. 2022. PMID: 35343235 Free article. Review.
Recent clinical-epidemiological studies have demonstrated challenges in our concept and measurement of premorbid disability or dementia while highlighting the significant proportion of the general stroke population that falls under this umbrella, risking exclusion from therapies. …
Recent clinical-epidemiological studies have demonstrated challenges in our concept and measurement of premorbid disability or dementia whil …
Long-Term Blood Pressure Variability and Major Adverse Cardiovascular and Cerebrovascular Events After Intracerebral Hemorrhage.
Castello JP, Teo KC, Abramson JR, Keins S, Takahashi CE, Leung IYH, Leung WCY, Wang Y, Kourkoulis C, Pavlos Myserlis E, Warren AD, Henry J, Chan KH, Cheung RTF, Ho SL, Gurol ME, Viswanathan A, Greenberg SM, Anderson CD, Lau KK, Rosand J, Biffi A. Castello JP, et al. Among authors: greenberg sm. J Am Heart Assoc. 2022 Mar 15;11(6):e024158. doi: 10.1161/JAHA.121.024158. Epub 2022 Mar 5. J Am Heart Assoc. 2022. PMID: 35253479 Free PMC article.
Methods and Results We analyzed data from prospective ICH cohort studies at Massachusetts General Hospital and the University of Hong Kong. We captured long-term (ie, visit-to-visit) BP variability, quantified as individual participants' variation coefficient. ...Average B …
Methods and Results We analyzed data from prospective ICH cohort studies at Massachusetts General Hospital and the University of Hong Kong. …
Histopathological correlates of haemorrhagic lesions on ex vivo magnetic resonance imaging in immunized Alzheimer's disease cases.
Scherlek AA, Kozberg MG, Nicoll JAR, Perosa V, Freeze WM, van der Weerd L, Bacskai BJ, Greenberg SM, Frosch MP, Boche D, van Veluw SJ. Scherlek AA, et al. Among authors: greenberg sm. Brain Commun. 2022 Feb 3;4(1):fcac021. doi: 10.1093/braincomms/fcac021. eCollection 2022. Brain Commun. 2022. PMID: 35224489 Free PMC article.
We hypothesized that these lesions would be associated with severe cerebral amyloid angiopathy. Ten cases were selected from the long-term follow-up study of patients who enrolled in the first clinical trial of active amyloid beta immunization with AN1792 for Alzheimer's d …
We hypothesized that these lesions would be associated with severe cerebral amyloid angiopathy. Ten cases were selected from the long-ter …
Biological and Social Determinants of Hypertension Severity Before vs After Intracerebral Hemorrhage.
Abramson JR, Castello JP, Keins S, Kourkoulis C, Rodriguez-Torres A, Myserlis EP, Alabsi H, Warren AD, Henry JQA, Gurol ME, Viswanathan A, Greenberg SM, Towfighi A, Skolarus L, Anderson CD, Rosand J, Biffi A. Abramson JR, et al. Among authors: greenberg sm. Neurology. 2022 Mar 29;98(13):e1349-e1360. doi: 10.1212/WNL.0000000000200003. Epub 2022 Feb 7. Neurology. 2022. PMID: 35131909 Free PMC article.
BACKGROUND AND OBJECTIVES: Although blood pressure (BP) control is considered the most effective measure to prevent functional decline after intracerebral hemorrhage (ICH), fewer than half of survivors achieve treatment goals. We hypothesized that long-term (i.e., prehemor …
BACKGROUND AND OBJECTIVES: Although blood pressure (BP) control is considered the most effective measure to prevent functional decline after …
Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy: international individual patient data pooled analysis.
Hostettler IC, Wilson D, Fiebelkorn CA, Aum D, Ameriso SF, Eberbach F, Beitzke M, Kleinig T, Phan T, Marchina S, Schneckenburger R, Carmona-Iragui M, Charidimou A, Mourand I, Parreira S, Ambler G, Jäger HR, Singhal S, Ly J, Ma H, Touzé E, Geraldes R, Fonseca AC, Melo T, Labauge P, Lefèvre PH, Viswanathan A, Greenberg SM, Fortea J, Apoil M, Boulanger M, Viader F, Kumar S, Srikanth V, Khurram A, Fazekas F, Bruno V, Zipfel GJ, Refai D, Rabinstein A, Graff-Radford J, Werring DJ. Hostettler IC, et al. Among authors: greenberg sm. J Neurol. 2022 Mar;269(3):1427-1438. doi: 10.1007/s00415-021-10706-3. Epub 2021 Jul 17. J Neurol. 2022. PMID: 34272978 Free PMC article.
METHODS: We performed a systematic review and international individual patient-data pooled analysis in patients with cSAH associated with probable or possible CAA diagnosed on baseline MRI using the modified Boston criteria. We used Cox proportional hazards models with a frailty …
METHODS: We performed a systematic review and international individual patient-data pooled analysis in patients with cSAH associated with pr …
Impact of Uncontrolled Hypertension at 3 Months After Intracerebral Hemorrhage.
Biffi A, Teo KC, Castello JP, Abramson JR, Leung IYH, Leung WCY, Wang Y, Kourkoulis C, Myserlis EP, Warren AD, Henry J, Chan KH, Cheung RTF, Ho SL, Anderson CD, Gurol ME, Viswanathan A, Greenberg SM, Lau KK, Rosand J. Biffi A, et al. Among authors: greenberg sm. J Am Heart Assoc. 2021 Jun;10(11):e020392. doi: 10.1161/JAHA.120.020392. Epub 2021 May 15. J Am Heart Assoc. 2021. PMID: 33998241 Free PMC article.
We investigated the frequency and prognostic impact of uncontrolled short-term hypertension after ICH. Methods and Results We analyzed data from Massachusetts General Hospital (n=1305) and the University of Hong Kong (n=523). ...Uncontrolled hypertension at 3 months was as …
We investigated the frequency and prognostic impact of uncontrolled short-term hypertension after ICH. Methods and Results We analyze …
Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID-19 pandemic, now and in the future.
Mok VCT, Pendlebury S, Wong A, Alladi S, Au L, Bath PM, Biessels GJ, Chen C, Cordonnier C, Dichgans M, Dominguez J, Gorelick PB, Kim S, Kwok T, Greenberg SM, Jia J, Kalaria R, Kivipelto M, Naegandran K, Lam LCW, Lam BYK, Lee ATC, Markus HS, O'Brien J, Pai MC, Pantoni L, Sachdev P, Skoog I, Smith EE, Srikanth V, Suh GH, Wardlaw J, Ko H, Black SE, Scheltens P. Mok VCT, et al. Among authors: greenberg sm. Alzheimers Dement. 2020 Nov;16(11):1571-1581. doi: 10.1002/alz.12143. Epub 2020 Aug 12. Alzheimers Dement. 2020. PMID: 32789951 Free PMC article. Review.
We believe this review will provide strategic directions and set standards for health-care leaders in dementia, including governmental bodies around the world in coordinating emergency response plans for protecting and caring for older people with dementia amid the COIVD-19 outbr …
We believe this review will provide strategic directions and set standards for health-care leaders in dementia, including governmental bodie …
Association Between Immunosuppressive Treatment and Outcomes of Cerebral Amyloid Angiopathy-Related Inflammation.
Regenhardt RW, Thon JM, Das AS, Thon OR, Charidimou A, Viswanathan A, Gurol ME, Chwalisz BK, Frosch MP, Cho TA, Greenberg SM. Regenhardt RW, et al. Among authors: greenberg sm. JAMA Neurol. 2020 Oct 1;77(10):1261-1269. doi: 10.1001/jamaneurol.2020.1782. JAMA Neurol. 2020. PMID: 32568365 Free PMC article.
These results raise the possibility that early blunting of CAA-ri and the autoimmune response may have long-term benefits for the subsequent disease course....
These results raise the possibility that early blunting of CAA-ri and the autoimmune response may have long-term benefits for the sub …
31 results