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Is "cellular senescence" a misnomer?
Gems D, Kern CC. Gems D, et al. Geroscience. 2022 Oct;44(5):2461-2469. doi: 10.1007/s11357-022-00652-x. Epub 2022 Sep 7. Geroscience. 2022. PMID: 36068483 Free PMC article. Review.
To open a discussion of this issue, we propose replacing the term cellular senescence with remodeling activation, and SASP with RASP (remodeling-associated secretory phenotype)....
To open a discussion of this issue, we propose replacing the term cellular senescence with remodeling activation, and SASP with RASP …
Death happy: adaptive ageing and its evolution by kin selection in organisms with colonial ecology.
Galimov ER, Gems D. Galimov ER, et al. Among authors: gems d. Philos Trans R Soc Lond B Biol Sci. 2021 Apr 26;376(1823):20190730. doi: 10.1098/rstb.2019.0730. Epub 2021 Mar 8. Philos Trans R Soc Lond B Biol Sci. 2021. PMID: 33678027 Free PMC article.
Exploring further the relationship between adaptive death and social interactions, we consider examples where adaptive death results more from action of kin than from self-destructive mechanisms and, to describe this, introduce the term adaptive killing of kin. This articl …
Exploring further the relationship between adaptive death and social interactions, we consider examples where adaptive death results more fr …
Nutritional Programming of Lifespan by FOXO Inhibition on Sugar-Rich Diets.
Dobson AJ, Ezcurra M, Flanagan CE, Summerfield AC, Piper MDW, Gems D, Alic N. Dobson AJ, et al. Among authors: gems d. Cell Rep. 2017 Jan 10;18(2):299-306. doi: 10.1016/j.celrep.2016.12.029. Cell Rep. 2017. PMID: 28076775 Free PMC article.
Consumption of unhealthy diets is exacerbating the burden of age-related ill health in aging populations. Such diets can program mammalian physiology to cause long-term, detrimental effects. Here, we show that, in Drosophila melanogaster, an unhealthy, high-sugar diet in e …
Consumption of unhealthy diets is exacerbating the burden of age-related ill health in aging populations. Such diets can program mammalian p …
Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice.
Selman C, Kerrison ND, Cooray A, Piper MD, Lingard SJ, Barton RH, Schuster EF, Blanc E, Gems D, Nicholson JK, Thornton JM, Partridge L, Withers DJ. Selman C, et al. Among authors: gems d. Physiol Genomics. 2006 Nov 27;27(3):187-200. doi: 10.1152/physiolgenomics.00084.2006. Epub 2006 Aug 1. Physiol Genomics. 2006. PMID: 16882887
Acute CR captured many, but not all, hepatic transcriptional changes of long-term CR. Our findings demonstrate a clear transcriptional response across multiple tissues during acute CR, with congruent plasma metabolite changes. ...Mice undergoing acute CR rapidly adopt many …
Acute CR captured many, but not all, hepatic transcriptional changes of long-term CR. Our findings demonstrate a clear transcriptiona …
Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm.
Weinkove D, Halstead JR, Gems D, Divecha N. Weinkove D, et al. Among authors: gems d. BMC Biol. 2006 Feb 3;4:1. doi: 10.1186/1741-7007-4-1. BMC Biol. 2006. PMID: 16457721 Free PMC article.
RESULTS: We find that in L1s both starvation and daf-16 are necessary to confer resistance to oxidative stress in the form of hydrogen peroxide. Accordingly, DAF-16 is localised to cell nuclei after short-term starvation. However, after long-term starvation, DAF-16 …
RESULTS: We find that in L1s both starvation and daf-16 are necessary to confer resistance to oxidative stress in the form of hydrogen perox …